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Adsorption cooling technologies driven by low-grade thermal or solar power are used as an energy-efficient alternative to conventional refrigeration and air conditioning systems. Explicit understanding of the adsorption cycles requires precise determination of the performance parameters, replication of the experimental data, and the rigorous study of the adsorption heat transformation method. Hence, the optimum adsorption isotherms model must be identified. Scientists often face difficulties in selecting the suitable isotherm model as there are many models for a particular form of adsorption isotherm. The present study introduces a novel approach for choosing the optimal models for each type of International Union of Pure and Applied Chemistry (IUPAC) classified adsorption isotherm using robust statistical methods. First, the box-and-whisker plots of error identification are employed. Tóth for Type-I(a) and Type-I(b), modified BET for Type-II, GAB for Type-III, Universal for Type-IV(a), and Type-IV(b), Sun Chakrabarty for Type-V, and Yahia et al. for Type-VI were found lower than the other candidate models in box-and-whisker plot. The optimality of our selected models was further verified using analysis of variance (ANOVA), pairwise Tukey honest significant difference (HSD) test, Kruskal–Wallis rank-sum test, and pairwise Wilcoxon rank-sum test. In short, rigorous statistical analysis was performed to identify the best model for each type of isotherm by minimizing error. Moreover, specific cooling effect (SCE) of Maxsorb III/ethanol and silica gel/water pairs were determined. Results showed that Tóth is the optimal isotherm model for the studied pairs, and the SCE values obtained from the model agree well with experimental data. The optimum isotherm model is indispensable for the precise designing of the next generation adsorption cooling cycles.

Multiple comparisons tests (MCTs) include the statistical tests used to compare groups (treatments) often following a significant effect reported in one of many types of linear models. Due to a variety of data and statistical considerations, several dozen MCTs have been developed over the decades, with tests ranging from very similar to each other to very different from each other. Many scientific disciplines use MCTs, including >40,000 reports of their use in ecological journals in the last 60 years. Despite the ubiquity and utility of MCTs, several issues remain in terms of their correct use and reporting. In this study, we evaluated 17 different MCTs. We first reviewed the published literature for recommendations on their correct use. Second, we created a simulation that evaluated the performance of nine common MCTs. The tests examined in the simulation were those that often overlapped in usage, meaning the selection of the test based on fit to the data is not unique and that the simulations could inform the selection of one or more tests when a researcher has choices. Based on the literature review and recommendations: planned comparisons are overwhelmingly recommended over unplanned comparisons, for planned non-parametric comparisons the Mann-Whitney-Wilcoxon U test is recommended, Scheffé’s S test is recommended for any linear combination of (unplanned) means, Tukey’s HSD and the Bonferroni or the Dunn-Sidak tests are recommended for pairwise comparisons of groups, and that many other tests exist for particular types of data. All code and data used to generate this paper are available at: https://github.com/stevemidway/MultipleComparisons .

Abstract Male Infertility due to diminished testosterone is one of the most common issues in the present-day scenario. Treating reproductive failure by enhancing the 3 β-hydroxysteroid dehydrogenase (3βHSD) and 17 β-hydroxysteroid dehydrogenase (17βHSD) can resolve this problem easily. There are various medicines readily available in the market that can aid in the steroidogenesis and thus, increases the spermatogenesis of an individual. But such medicines might have side effects in the long run and thus a cost-effective solution bereft of any side-effect is required. Medicinal plants have bioactive compound that can provide us the solution. In this piece of experimental work, the methanolic extract of Mucuna pruriens (MeMP) seeds were administered in a bisphenol A-induced model of mice with reproductive toxicity. The extract was found to elevate the total cholesterol, lipid, and protein levels in testis. Apart from that it was shown to directly enhance the 3βHSD and17βHSD which also results in the testosterone level increase. Traditionally this plant has been used by the tribals of north eastern India with the belief that it increases male fertility. The laboratory work has suggested similar results as MeMP has increased the fertility indices of the male mice by regulating the steroidogenic process. In-silico studies have suggested that certain compounds of this seed extract have drug likeliness and a good binding affinity as per the clomiphene citrate-standard drug. Research Highlights  Commonly used plasticisers like bisphenol A acts as an endocrine disruptor and can disrupt the testosterone levels in male mice.Naturopathy can be a cost-effective and minimal side-effect solution for preventing or treating male infertility.The methanolic extract of M. pruriens seeds can ameliorate the disruption in the levels of steroidogenic proteins, that is, 3βHSD and 17βHSD, thus resetting the steroidogenesis.M. pruriens seed extract was seen to increase the testosterone levels and had profertile effects against the Bisphenol-A induced toxic mice.In-silico analysis of the extract has also suggested the presence of certain compounds that has an equivalent binding energy with the proteins as compared to the clomiphene citrate (standard drug).The pharmacokinetic results also suggest future possibilities of drug making for male infertility from the seeds of M. pruriens. Graphical Abstract Graphical Abstract

Biodiesel is a clean-burning, alternative diesel replacement fuel that may be used in existing diesel engines in either pure or blended form without or with modest modifications. In some countries, biodiesel is recommended as a potential alternative to diesel fuel since it is a renewable energy source that is environmentally benign. The main problems with the widespread commercialization of biodiesel are its high viscosity and its limited feedstock, due to which complete replacement of diesel fuel is not possible and the use of blends of biodiesel and petrodiesel are being used increasingly worldwide. The paper presents a behavioral study of the petro-based diesel, and their blend (B20, B40, B60, B80) with Pongamia and Jatropha biodiesel. The results reveal a considerable viscosity lowering due to the dilution effect of increasing diesel concentration in both the cases. In addition, improvements in oxidation stability in both cases have also been observed. The research shows that as the biodiesel concentration increases, the stability of blends decreases. In blending Jatropha curcus methyl ester with EURO-III and EURO-IV HSD, the ester’s viscosity decreased as the diesel level in the blends increased, and blends comprised up to 80 percent biodiesel remained below the viscosity limit. Pongamia pinnata blends with both fuels above 60% diesel; however, exceeds the stipulated viscosity limit of 4.50 cSt at 40 °C.

Motivating the employees is considered one of the essential manager’s skills. Knowledge of powerful motivation factors allow managers to motivate employees effectively. It results in motivated employees able to affect a success of enterprises and its competitive advantage. Following the research carried out using 34,000 Slovak employees, the importance of motivation factors relating to finance was defined. Tukey’s HSD test, as a part of the ANOVA analysis, was used for extensive investigation into the most important motivation factors relating to finance. It is supposed that motivation of employees of different gender, age and job position will differ. The suppositions were confirmed by the results achieved in the research showing significant differences between individual employee categories of managers, blue-collar workers and white-collar workers. Taking into consideration the results, managers are suggested to concentrate on motivating the employees as parts and not as a whole because of the differences in the needs of employees in terms of gender, age and mainly job position. First published online 30 October 2020

Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α‐HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection‐induced) and associated activation of transcription factors: NF‐кB and AP‐1, common to term and preterm labour. We found that 20α‐HSD protein is significantly increased in human myometrium during term labour, and in mouse uterus during term and preterm labour. Treatment of human myometrial cells with the pro‐inflammatory mediators, lipopolysaccharide (LPS, mimicking infection) and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA, mimicking inflammation), induced 20α‐HSD gene expression and increased 20α‐HSD protein abundance. LPS treatment decreased P4 release into the culture medium and resulted in up‐regulation of GJA1 in the hTERT‐HM cells. The NF‐кB /AP‐1 transcription factors mediated effects of LPS and TPA on 20α‐HSD gene transcription. Both pro‐inflammatory stimuli induced 20α‐HSD promoter activity in LPS/TPA‐treated cells which was significantly attenuated by inhibition of NF‐кB (JSH: 20 µM) or AP‐1 signalling (T5224: 10 µM). Deletion of NF‐кB consensus sites abrogated LPS‐mediated promoter induction, while removal of AP‐1 sites reversed the TPA‐mediated induction of 20α‐HSD promoter. We conclude that inflammatory stimuli (physiologic or pathologic) that activate NF‐кB or AP‐1 induce 20α‐HSD transcription and subsequent local P4 withdrawal resulting in up‐regulation of GJA1 and activation of myometrium that precedes labour.

Ovarian follicle steroidogenesis associated with embryo quality results in a successful pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete several steroid and peptide hormones. Follicles harvested from women who conceived after assisted reproductive therapy (ART) had significantly higher estradiol levels in follicular fluids than the follicles from women who failed to conceive after ART. The higher follicular estradiol levels correlate well with successful fertilization following ART. Mitochondria are the central sites for steroid hormone biosynthesis. The first and rate-limiting step in the biosynthesis of steroid hormones occurs in the mitochondria of granulosa cells. In the present study, we hypothesized that the mitochondria in granulosa cells are critical for maintaining oocyte quality and fertility capacity. This study aims to clarify the relationship between mitochondrial function and granulosa cell steroidogenesis, and the relationship between hormone levels and fertility capacity. Sera, follicular fluids and granulosa cells were obtained from individuals undergoing IVF-ET treatment. The oocyte numbers, oocyte quality, fertilization rate, and pregnancy rate were also recorded. The patients who provided the granulosa cells were further classified into four groups: endometriosis, ovarian endometrioma, endometriosis without ovarian endometrioma, and polycystic ovary syndrome (PCOS); patients with other female factor infertility and male factor infertility were used as controls. We measured the levels of estradiol (E2) by radioimmunoassay. Concurrently, we analyzed the mitochondrial mass and membrane potential, and apoptosis by flow cytometry using nonyl acridine orange, TMRE, Annexin V-FITC and PI. Mitochondrial morphology was visualized by transfection with pLV-mitoDsRed. In addition, we assessed the protein levels of steroidogenic enzymes, steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) by Western blot. The results showed significantly decreased serum E2 and follicular E2 levels, and decreased IVF outcomes, in the patients with endometriosis. Reduced mitochondrial mass and decreased mitochondrial membrane potential were correlated with lower E2. Furthermore, a significant decrease in StAR and 3β-HSD was found in patients with ovarian endometrioma. The enzyme levels of StAR and 3β-HSD were highly correlated with E2 levels. Finally, elevated cumulus cell apoptosis was found in the patient group with ovarian endometrioma and PCOS. In conclusion, mitochondrial dysfunction of human granulosa cells may contribute to the decline of steroidogenesis, decreased fertilization rate, oocyte maturation rate, and oocyte quality, and it can ultimately jeopardize fertility.

Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations.

Glucocorticoids (GCs), which are secreted by the adrenal cortex, are important regulators in the metabolism of carbohydrates, lipids, and proteins. For the proper functioning of the body, strict control of their release is necessary, as increased GCs levels may contribute to the development of obesity, type 2 diabetes mellitus, hypertension, cardiovascular diseases, and other pathological conditions contributing to the development of metabolic syndrome. 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) locally controls the availability of the active glucocorticoid, namely cortisol and corticosterone, for the glucocorticoid receptor. Therefore, the participation of 11β-HSD1 in the development of metabolic diseases makes both this enzyme and its inhibitors attractive targets in the pharmacotherapy of the above-mentioned diseases.

This study aimed to examine the energy and exergy indices of the rosemary drying process in a hybrid-solar dryer (HSD) and the effects of air-drying parameters on these thermodynamic indices. Drying experiments were carried out at four levels of air temperature (40, 50, 60, and 70 ∘C) and three levels of air velocity (1, 1.5, and 2 m/s). Energy and exergy were calculated by application of the first and second laws of thermodynamics. Based on the principal laws, energy efficiency, exergy losses, and exergetic improvement potential rate, were evaluated. The results showed that the energy utilization ratio (EUR) ranged from 0.246 to 0.502, and energy utilization (EU) ranged from 0.017 to 0.060 (kJ/s). Exergy loss and efficiency varied from 0.009 to 0.028 (kJ/s) and from 35.08% to 78.5%, respectively, and increased with increased temperature and air velocity. It was found that the exergy loss rate was affected by temperature and air velocity because the overall heat transfer coefficient was different under these conditions. By comparison, with increasing temperature and air velocity, the exergy efficiency increased. Because most energy is used to evaporate moisture, this behavior may be explained by improved energy utilization. The drying chamber sustainability index ranged from 0.0129 to 0.0293. This study provides insights into the optimization process of drying operations and operational parameters in solar hybrid dryers that reduce energy losses and consumption.