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The Invention Hunters discover how machines work
\"When the Invention Hunters, a group of globe-trotting invention collectors, visit a construction site in their flying museum, a boy helps them by explaining how simple machines like levers, pulleys, and cranks work\"-- Provided by publisher.
Book
Enhancing domain-aware multi-truth data fusion using copy-based source authority and value similarity
Data fusion, within the data integration pipeline, addresses the problem of discovering the true values of a data item when multiple sources provide different values for it. An important contribution to the solution of the problem can be given by assessing the quality of the involved sources and relying more on the values coming from trusted sources. State-of-the-art data fusion systems define source trustworthiness on the basis of the accuracy of the provided values and on the dependence on other sources, and recently it has been also recognized that the trustworthiness of the same source may vary with the domain of interest. In this paper we propose STORM, a novel domain-aware algorithm for data fusion designed for the multi-truth case, that is, when a data item can also have multiple true values. Like many other data-fusion techniques, STORM relies on Bayesian inference. However, differently from the other Bayesian approaches to the problem, it determines the trustworthiness of sources by taking into account their authority: Here, we define authoritative sources as those that have been copied by many other ones, assuming that, when source administrators decide to copy data from other sources, they choose the ones they perceive as the most reliable. To group together the values that have been recognized as variants representing the same real-world entity, STORM provides also a value-reconciliation step, thus reducing the possibility of making mistakes in the remaining part of the algorithm. The experimental results on multi-truth synthetic and real-world datasets show that STORM represents a solid step forward in data-fusion research.
Journal Article
Bio-Inspired Design of Superconducting Spiking Neuron and Synapse
The imitative modelling of processes in the brain of living beings is an ambitious task. However, advances in the complexity of existing hardware brain models are limited by their low speed and high energy consumption. A superconducting circuit with Josephson junctions closely mimics the neuronal membrane with channels involved in the operation of the sodium-potassium pump. The dynamic processes in such a system are characterised by a duration of picoseconds and an energy level of attojoules. In this work, two superconducting models of a biological neuron are studied. New modes of their operation are identified, including the so-called bursting mode, which plays an important role in biological neural networks. The possibility of switching between different modes in situ is shown, providing the possibility of dynamic control of the system. A synaptic connection that mimics the short-term potentiation of a biological synapse is developed and demonstrated. Finally, the simplest two-neuron chain comprising the proposed bio-inspired components is simulated, and the prospects of superconducting hardware biosimilars are briefly discussed.
Journal Article
Throughput and resolution with a next-generation direct electron detector
Direct electron detectors (DEDs) have revolutionized cryo-electron microscopy (cryo-EM) by facilitating the correction of beam-induced motion and radiation damage, and also by providing high-resolution image capture. A new-generation DED, the DE64, has been developed by Direct Electron that has good performance in both integrating and counting modes. The camera has been characterized in both modes in terms of image quality, throughput and resolution of cryo-EM reconstructions. The modulation transfer function, noise power spectrum and detective quantum efficiency (DQE) were determined for both modes, as well as the number of images per unit time. Although the DQE for counting mode was superior to that for integrating mode, the data-collection throughput for this mode was more than ten times slower. Since throughput and resolution are related in single-particle cryo-EM, data for apoferritin were collected and reconstructed using integrating mode, integrating mode in conjunction with a Volta phase plate (VPP) and counting mode. Only the counting-mode data resulted in a better than 3 Å resolution reconstruction with similar numbers of particles, and this increased performance could not be compensated for by the increased throughput of integrating mode or by the increased low-frequency contrast of integrating mode with the VPP. These data show that the superior image quality provided by counting mode is more important for high-resolution cryo-EM reconstructions than the superior throughput of integrating mode.
Journal Article
Dynamic Walking: Toward Agile and Efficient Bipedal Robots
Dynamic walking on bipedal robots has evolved from an idea in science fiction to a practical reality. This is due to continued progress in three key areas: a mathematical understanding of locomotion, the computational ability to encode this mathematics through optimization, and the hardware capable of realizing this understanding in practice. In this context, this review article outlines the end-to-end process of methods which have proven effective in the literature for achieving dynamic walking on bipedal robots. We begin by introducing mathematical models of locomotion, from reduced order models that capture essential walking behaviors to hybrid dynamical systems that encode the full order continuous dynamics along with discrete footstrike dynamics. These models form the basis for gait generation via (nonlinear) optimization problems. Finally, models and their generated gaits merge in the context of real-time control, wherein walking behaviors are translated to hardware. The concepts presented are illustrated throughout in simulation, and experimental instantiation on multiple walking platforms are highlighted to demonstrate the ability to realize dynamic walking on bipedal robots that is agile and efficient.
Paper