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P93 Concomitant presence of allergic rhinitis (AR) in chronic/fibrotic hypersensitivity pneumonitis (C/F-HP) patients: a significant correlation!
BackgroundChronic/Fibrotic Hypersensitivity Pneumonitis (C/F-HP), inspite of its high prevalence, is often underdiagnosed due to the complexity of its diagnostic process, which typically involves lung biopsies. These invasive procedures carry significant risks, especially for patients who are severely ill. This study explores the potential of Allergic Rhinitis as a non-invasive clinical indicator for diagnosing C/F-HP, aiming to simplify the diagnostic approach and reduce the need for biopsies.ObjectiveThe objective of this study was to assess the occurrence of AR in patients with C/F-HP and evaluate its utility as a clinical marker for non-invasive diagnosis.MethodThis cross-sectional descriptive study was conducted at BAM&DC Multan between July 2021 and December 2022. A total of 107 patients diagnosed with C/F-HP, aged 18 to 60, were enrolled using a consecutive sampling technique. The exclusion criteria included patients with known causes of Interstitial Lung Disease and comorbid conditions. Allergic Rhinitis was diagnosed based on clinical history and serum IgE levels, following AAFP guidelines.ResultsThe study comprised 107 C/F-HP patients, with a mean age of 46.73 ± 9.36 years. Male patients accounted for 59.8% of the cohort. AR was diagnosed in 99 out of 107 patients (92.5%), with an average serum IgE level of 542.65 ± 182.93. A small percentage (3.7%) of AR patients had normal IgE levels, possibly due to prior corticosteroid use. Among AR-positive patients, males outnumbered females (62:37), reflecting a similar ratio in the overall C/F-HP population.Abstract P93 Table 1Demographic characteristics of patients with chronic hypersensitivity pneumonitis (N=107)ConclusionThis study highlights a significant correlation between AR and C/F-HP, suggesting that AR could serve as a reliable clinical indicator for C/F-HP diagnosis, potentially reducing the need for invasive lung biopsies. It seems that our Hypothesis ‘in an uncertain ILD patient, if AR is concomitantly present, C/F-HP should be sought out’, stands validated. Further research is recommended to solidify these findings.
Journal Article
The statesman and the storyteller : John Hay, Mark Twain, and the rise of American imperialism
\"John Hay, famous as Lincoln's private secretary and later as secretary of state under presidents McKinley and Roosevelt, and Samuel Langhorne Clemens, famous for being 'Mark Twain,' grew up fifty miles apart, on the banks of the Mississippi River, in the same rural antebellum stew of race and class and want. This shared history helped draw them together when they first met as up-and-coming young men in the late 1860s, and their mutual admiration never waned in spite of sharp differences in personality, in worldview, and in public conduct. In [this book], the last decade of their lives plays out against the tumultuous events of the day, as the United States government begins to aggressively pursue a policy of imperialism, overthrowing the duly elected queen of Hawaii; violently wresting Cuba, Puerto Rico, and the Philippines away from Spain, and then from the islands' inhabitants; and finally encouraging and supporting a revolution to clear a path for the building of the U.S.-controlled Panama Canal\"-- Provided by publisher.
Book
Corrigendum to: Effectiveness of topical intranasal Curcumin in the experimentally induced allergic rhinitis model in rats
In the above-mentioned article, the authors wish to correct several points related to reporting consistency, statistical terminology, and citation accuracy. These corrections do not affect the results or the conclusions of the study.
Journal Article
The poisonous solicitor : the true story of a 1920s murder mystery
In 1922, Major Herbert Armstrong, a Hay-on-Wye solicitor, was found guilty of, and executed for, poisoning his wife, Katharine, with arsenic. Armstrong's case has all the ingredients of a classic murder mystery, from a plot by Agatha Christie or Dorothy Sayers. It is a near-perfect whodunnit. 100 years later, Stephen Bates examines and retells the story of the case, evoking the period and atmosphere of the early 1920s, a time of newspaper sensationalism, hypocrisy and sanctimonious morality.
BOOK
P252 Involvement of myeloid-derived suppressor cells in allergic airway diseases: preliminary results of a systematic review of the literature
Introduction and ObjectivesMyeloid-derived suppressor cells (MDSCs) are immature cells of the myeloid lineage with immunosuppressive properties, divided into polymorphonuclear and monocytic subpopulations, and are commonly involved in chronic inflammatory diseases. We aimed to systematically review the literature to assess the quantitative and qualitative alterations of MDSCs and their involvement in allergic airway diseases, i.e. asthma and allergic rhinitis.MethodsThe systematic review protocol was registered in PROSPERO, and the PRISMA guidelines for systematic reviews were followed. The databases MEDLINE via PubMed, Embase, and Scopus were systematically searched for original research studies involving the measurement of human MDSCs in allergic airway diseases by the end of 2024. A narrative synthesis of the extracted data from the included studies was performed.ResultsAmong a total of 429 records screened, 8 studies were considered eligible to be included in the review. The studies were run from 2011 to 2021 and cumulatively included 212 patients with asthma and 90 patients with allergic rhinitis. Healthy controls (cumulatively 203) were included in 7 studies, while 4 studies also included patients with other respiratory diseases for comparison, i.e. chronic obstructive pulmonary disease (35 patients), pneumonia (65 patients), and respiratory viral infections (27 patients). Out of 6 studies about asthma, MDSC counts were found either increased or increasing after allergen challenge in bronchoalveolar lavage (2 studies) and in peripheral blood mononuclear cells (3 studies), while the monocytic MDSC subpopulation was found downregulated in isolated white blood cells in only 1 study. The 2 studies about allergic rhinitis used diverse experimental set-ups and were not comparable.ConclusionsIncreased counts of MDSCs are mostly found in asthma, pointing towards the role of these immunomodulatory cells in its pathogenesis, despite the heterogeneity of the methodology among the different studies. Further research and harmonisation of the markers and techniques for the identification of MDSCs is needed, as they may be used as novel biomarkers and therapeutic targets in these disease entities.
Journal Article
Critical appraisal of reporting, statistical methodology, and interpretation in a preclinical intranasal curcumin model of allergic rhinitis
This letter highlights key reporting and methodological issues in Demir et al.’s preclinical study assessing intranasal curcumin in an ovalbumin-induced allergic rhinitis rat model. We note an inconsistency in the reported number of experimental groups, potential misuse of parametric testing for ordinal histopathology scores, and overinterpretation of non-significant IgE comparisons as “comparable efficacy.” We also identify a citation mismatch regarding human clinical evidence and emphasize the need for clearer discussion of local tolerability signals, including goblet cell changes.
Journal Article