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"Hazardous Substances - adverse effects"
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Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to the glo Tobacco Heating Product: A Randomized, Controlled Ambulatory Study
Abstract
Introduction
Tobacco heating products (THPs) generate lower machine yields of toxicants compared to those found in conventional cigarette smoke. During use, these products are likely to expose users to lower levels of particulate matter and harmful and potentially harmful compounds compared with smoking cigarettes.
Aims and Methods
This randomized, controlled study is investigating whether biomarkers of exposure (BoE) to smoke toxicants are reduced when smokers switch from smoking cigarettes to using the glo THP in a naturalistic, ambulatory setting. Control groups include smokers who are abstaining from cigarette smoking and never-smokers. At a baseline study visit, 24-hour urine samples and spot blood samples were taken for BoE analysis, and exhaled carbon monoxide was also measured. N-(2-cyanoethyl) valine (CEVal) was used as a marker of compliance in subjects asked to refrain from combustible cigarette smoking. Subjects are being followed up at periodic intervals for 360 days; this article presents data following a planned interim analysis at day 90.
Results
In continuing smokers, BoE remained stable between baseline (day 1) and day 90. In both per-protocol and CEVal-compliant analysis populations, reductions in BoE were observed in subjects switching to using glo or undergoing smoking cessation. These reductions were statistically significant for a number of BoE when switching to glo was compared with continued smoking. Furthermore, in both populations, reductions observed in subjects switching to using glo were comparable to those seen with smoking cessation and were also to levels similar to those seen in never-smokers.
Conclusion
glo is a reduced-exposure tobacco product.
Implications
This clinical study builds on a previous 5-day confinement study and demonstrates that when smokers switched from smoking combustible cigarettes to using the glo THP in a naturalistic, ambulatory setting, their exposure to tobacco smoke toxicants was significantly decreased. For most BoE examined, this was to the same extent as that seen when a control group of smokers ceased cigarette smoking, or even to levels seen in never-smoker controls. This indicates that glo is a reduced-exposure product with the potential to be a reduced-risk tobacco product, when used by smokers whose cigarette consumption is displaced completely.
Clinical trial registration
ISRCTN81075760.
Journal Article
Flavored Versus Nonflavored Waterpipe Tobacco: A Comparison of Toxicant Exposure, Puff Topography, Subjective Experiences, and Harm Perceptions
Flavored waterpipe (WP) tobacco is the main type of tobacco used by young WP smokers, and a major factor attracting youth to smoke. However, evidence regarding the effect of limiting flavor on WP smokers' experience continues to be lacking. This study aims at evaluating the effect of flavor restriction on WP smokers' toxicant exposure, smoking topography, subjective experiences and harm perception.
Thirty-two WP smokers completed two, 45-minute ad libitum smoking sessions (preferred flavor vs non-flavored tobacco) in a crossover design pilot study. Plasma nicotine concentration and exhaled carbon monoxide (eCO) were measured before and after each smoking session. Puff topography was recorded throughout the smoking session. Participants completed survey questionnaires assessing subjective smoking experiences and harm perception.
Significant differences were observed in plasma nicotine concentration between the two WP tobacco conditions, with a higher increase in plasma nicotine concentration following the flavored tobacco session. There were no significant differences between the two WP tobacco conditions for eCO and smoking topography measures. Compared with the non-flavored WP tobacco, we documented enhanced subjective smoking measures of satisfaction, calmness, taste, puff liking and enjoyment following the preferred flavored WP tobacco session. Cigarette harm perception was significantly higher among participants after smoking their preferred flavor compared with non-flavored WP tobacco.
Limiting tobacco flavor has a substantial effect on WP smokers' nicotine exposure, subjective experience and harm perception. Therefore, eliminating or restricting WP flavors could be an essential element of comprehensive tobacco control policies to reduce the appeal of WP tobacco products for youth.
This study highlights the important role of flavor in shaping WP smokers' experiences and exposures and the potential impact that regulating flavored WP tobacco may have on curbing WP use among youth in the US. Such regulations may reduce the appeal and the interest in WP smoking initiation and continued use.
Journal Article
A Town Called Asbestos : Environmental Contamination, Health, and Resilience in a Resource Community
\"For decades, manufacturers from around the world relied on asbestos from the town of Asbestos, Quebec, to produce fire-retardant products. Then, over time, people learned about the mineral's devastating effects on human health. Dependent on this deadly industry for their community's survival, the residents of Asbestos developed a unique, place-based understanding of their local environment; the risks they faced living next to the giant opencast mine; and their place within the global resource trade. This book unearths the local/global tensions that defined Asbestos's proud and painful history to reveal the challenges similar resource communities have faced--and continue to face today.\"--Page 4 of cover.
Book
Air pollution: a global problem needs local fixes
Researchers must find the particles that are most dangerous to health in each place so policies can reduce levels of those pollutants first, urge Xiangdong Li and colleagues.
Researchers must find the particles that are most dangerous to health in each place so policies can reduce levels of those pollutants first, urge Xiangdong Li and colleagues.
Photographers take photos on the roof of a building in heavy smog in Zhengzhou, China
Journal Article
Determinants of early-stage hearing loss among a cohort of young workers with 16-year follow-up
ObjectivesThe authors had a unique opportunity to study the early impacts of occupational and recreational exposures on the development of noise-induced hearing loss (NIHL) in a cohort of 392 young workers. The objectives of this study were to estimate strength of associations between occupational and recreational exposures and occurrence of early-stage NIHL and to determine the extent to which relationships between specific noise exposures and early-stage NIHL were mitigated through the use of hearing protection.MethodsParticipants were young adults who agreed to participate in a follow-up of a randomised controlled trial. While the follow-up study was designed to observe long-term effects (up to 16 years) of a hearing conservation intervention for high school students, it also provided opportunity to study the potential aetiology of NIHL in this worker cohort. Study data were collected via exposure history questionnaires and clinical audiometric examinations.ResultsOver the 16-year study period, the authors documented changes to hearing acuity that exceeded 15 dB at high frequencies in 42.8% of men and 27.7% of women. Analyses of risk factors for NIHL were limited to men, who comprised 68% of the cohort, and showed that risks increased in association with higher levels of the most common recreational and occupational noise sources, as well as chemical exposures with ototoxic potential. Use of hearing protection and other safety measures, although not universal and sometimes modest, appeared to offer some protection.ConclusionsEarly-stage NIHL can be detected in young workers by measuring high-frequency changes in hearing acuity. Hearing conservation programmes should focus on a broader range of exposures, whether in occupational or non-occupational settings. Priority exposures include gunshots, chainsaws, power tools, smoking and potentially some chemical exposures.
Journal Article
Uncovering global-scale risks from commercial chemicals in air
Commercial chemicals are used extensively across urban centres worldwide
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, posing a potential exposure risk to 4.2 billion people
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. Harmful chemicals are often assessed on the basis of their environmental persistence, accumulation in biological organisms and toxic properties, under international and national initiatives such as the Stockholm Convention
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. However, existing regulatory frameworks rely largely upon knowledge of the properties of the parent chemicals, with minimal consideration given to the products of their transformation in the atmosphere. This is mainly due to a dearth of experimental data, as identifying transformation products in complex mixtures of airborne chemicals is an immense analytical challenge
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. Here we develop a new framework—combining laboratory and field experiments, advanced techniques for screening suspect chemicals, and in silico modelling—to assess the risks of airborne chemicals, while accounting for atmospheric chemical reactions. By applying this framework to organophosphate flame retardants, as representative chemicals of emerging concern
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, we find that their transformation products are globally distributed across 18 megacities, representing a previously unrecognized exposure risk for the world’s urban populations. More importantly, individual transformation products can be more toxic and up to an order-of-magnitude more persistent than the parent chemicals, such that the overall risks associated with the mixture of transformation products are also higher than those of the parent flame retardants. Together our results highlight the need to consider atmospheric transformations when assessing the risks of commercial chemicals.
A new framework is proposed for assessing the risks of the atmospheric transformation products of commercial chemicals, combining laboratory and field experiments, advanced techniques for screening suspect chemicals, and in silico modelling.
Journal Article
Monitoring for health hazards at work
Monitoring for Health Hazards at Work has become an essential companion for students and professionals in occupational hygiene, offering a concise account of the dangers faced in a wide variety of work environments and giving practical, step-by-step guidance to gauge exposure. It includes: Coverage of most major health hazards: airborne dust, fibres, gases, vapours, noise, radiation, and biological agents Accounts of the latest equipment and techniques required to monitor such hazards Full guidance on how to undertake risk assessments Now thoroughly revised and restructured by an eminent new team of authors, the fourth edition brings this valuable handbook right up to date.
eBook
Environmental Health Risks and Housing Values: Evidence from 1,600 Toxic Plant Openings and Closings
Regulatory oversight of toxic emissions from industrial plants and understanding about these emissions ' impacts are in their infancy. Applying a research design based on the openings and closings of 1,600 industrial plants to rich data on housing markets and infant health, we find that: toxic air emissions affect air quality only within 1 mile of the plant; plant openings lead to 11 percent declines in housing values within 0.5 mile or a loss of about $ 4.25 million for these households; and a plant's operation is associated with a roughly 3 percent increase in the probability of low birthweight within 1 mile.
Journal Article