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Not a chimp : the hunt to find the genes that make us human
Humans are primates, and our closest relatives are the other African apes - chimpanzees closest of all. With the mapping of the human genome, and that of the chimp, a direct comparison of the differences between the two, letter by letter along the billions of As, Gs, Cs, and Ts of the DNA code, has led to the widely vaunted claim that we differ from chimps by a mere 1.6% of our genetic code. A mere hair's breadth genetically! To a rather older tradition of anthropomorphizing chimps, trying to get them to speak, dressing them up for 'tea parties', was added the stamp of genetic confirmation. It also began an international race to find that handful of genes that make up the difference - the genes that make us uniquely human. But what does that 1.6% really mean? And should it really lead us to consider extending limited human rights to chimps, as some have suggested? Are we, after all, just chimps with a few genetic tweaks? Is our language and our technology just an extension of the grunts and ant-collecting sticks of chimps? In this book, Jeremy Taylor sketches the picture that is emerging from cutting edge research in genetics, animal behaviour, and other fields. The indications are that the so-called 1.6% is much larger and leads to profound differences between the two species. We shared a common ancestor with chimps some 6-7 million years ago, but we humans have been racing away ever since. One in ten of our genes, says Taylor, has undergone evolution in the past 40,000 years! Some of the changes that happened since we split from chimpanzees are to genes that control the way whole orchestras of other genes are switched on and off, and where. Taylor shows, using studies of certain genes now associated with speech and with brain development and activity, that the story looks to be much more complicated than we first thought. This rapidly changing and exciting field has recently discovered a host of genetic mechanisms that make us different from other apes. As Taylor points out, for too long we have let our sentimentality for chimps get in the way of our understanding. Chimps use tools, but so do crows. Certainly chimps are our closest genetic relatives. But relatively small differences in genetic code can lead to profound differences in cognition and behaviour. Our abilities give us the responsibility to protect and preserve the natural world, including endangered primates. But for the purposes of human society and human concepts such as rights, let's not pretend that chimps are humans uneducated and undressed. We've changed a lot in those 12 million years.
eBook
Choosing children : genes, disability, and design
Progress in genetic and reproductive technology now offers us the possibility of choosing what kinds of children we do and don't have. Should we welcome this power, or should we fear its implications? There is no ethical question more urgent than this: we may be at a turning-point in the history of humanity. This book shows us how we might try to answer this question, and examines other provoking and disturbing questions. Surely parents owe it to their children to give them the best life they can? Increasingly we are able to reduce the number of babies born with disabilities and disorders. But there is a powerful new challenge to conventional thinking about the desirability of doing so: this comes from the voices of those who have these conditions. They call into question the very definition of disability. How do we justify trying to avoid bringing people like them into being? In 2002 a deaf couple used sperm donated by a friend with hereditary deafness to have a deaf baby: they took the view that deafness is not a disability, but a difference. Starting with the issues raised by this case, this book examines the emotive idea of ‘eugenics’, and the ethics of attempting to enhance people, for non-medical reasons, by means of genetic choices. Should parents be free, not only to have children free from disabilities, but to choose, for instance, the colour of their eyes or hair? This is no longer a distant prospect, but an existing power which we cannot wish away. What impact will such interventions have, both on the individuals concerned and on society as a whole? Should we try to make general improvements to the genetic make-up of human beings? Is there a central core of human nature with which we must not interfere?
eBook
The Genetic Gods
They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious faith.
The book explains how the genetic gods figure in our development--not just our metabolism and physiology, but even our emotional disposition, personality, ethical leanings, and, indeed, religiosity. Yet genes are physical rather than metaphysical entities. Having arisen via an amoral evolutionary process--natural selection--genes have no consciousness, no sentient code of conduct, no reflective concern about the consequences of their actions. It is Avise's contention that current genetic knowledge can inform our attempts to answer typically religious questions--about origins, fate, and meaning. The Genetic Gods challenges us to make the necessary connection between what we know, what we believe, and what we embody.
eBook
DNA : the story of the genetic revolution
\"James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. [This edition has been] updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research\"--Provided by publisher.
BOOK
Validation of High Resolution Melting Analysis (HRM) of the Amplified ITS2 Region for the Detection and Identification of Yeasts from Clinical Samples: Comparison with Culture and MALDI-TOF Based Identification
Candida species are known as opportunistic pathogens, and a possible cause of invasive infections. Because of their species-specific antimycotic resistance patterns, reliable techniques for their detection, quantification and identification are needed. We validated a DNA amplification method for direct detection of Candida spp. from clinical samples, namely the ITS2-High Resolution Melting Analysis (direct method), by comparing it with a culture and MALDI-TOF Mass Spectrometry based method (indirect method) to establish the presence of Candida species in three different types of clinical samples.
A total of 347 clinical samples, i.e. throat swabs, rectal swabs and vaginal swabs, were collected from the gynaecology/obstetrics, intensive care and haematology wards at the Ghent University Hospital, Belgium. For the direct method, ITS2-HRM was preceded by NucliSENS easyMAG DNA extraction, directly on the clinical samples. For the indirect method, clinical samples were cultured on Candida ID and individual colonies were identified by MALDI-TOF.
For 83.9% of the samples there was complete concordance between both techniques, i.e. the same Candida species were detected in 31.1% of the samples or no Candida species were detected in 52.8% of the samples. In 16.1% of the clinical samples, discrepant results were obtained, of which only 6.01% were considered as major discrepancies. Discrepancies occurred mostly when overall numbers of Candida cells in the samples were low and/or when multiple species were present in the sample.
Most of the discrepancies could be decided in the advantage of the direct method. This is due to samples in which no yeast could be cultured whereas low amounts could be detected by the direct method and to samples in which high quantities of Candida robusta according to ITS2-HRM were missed by culture on Candida ID agar. It remains to be decided whether the diagnostic advantages of the direct method compensate for its disadvantages.
Journal Article