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A joint effort led by the African Development Bank and the World Bank, 'Leveraging Migration for Africa' is the first comprehensive publication on harnessing migration, remittances, and other diaspora resources for the development of Africa. It comes at a time when countries in Africa and elsewhere are grappling with difficult choices on how to manage migration.Policy makers can help leverage the contributions of migrants to the development of Africa, reduceremittance costs, improve the efficiency of remittance markets in both origin and destination countries, and address the needs of the origin countries without restricting the emigration of high-skilled professionals. Innovative financing mechanisms such as issuance of diaspora bonds and securitization of future remittance flows can help finance big-ticket projects, such as railways, roads, power plants, and institutions of higher learning that will, step by step, help to transform Africa. This volume contributes to a greater understanding of migration and its potential role in Africa?s development.

This book is a call to rethink migration regimes in Southern Africa in ways that are more explicitly developmental and focused on poverty. Current policy debates are devoted almost exclusively to border control and policing; they pay only lip service to local and regional developmental strategies. This volume takes a different approach. Its contributors are scholars who are convinced that empirically based policy making stands a better chance of succeeding than untested preconceptions that risk reproducing recipes that have failed elsewhere. The book is therefore strong on empirics, providing a wealth of original data. It also reframes existing approaches and reexamines secondary data from fresh perspectives. Although the focus remains South Africa, the book reflects South Africa's regional role and draws on data from across the Southern African Development Community (SADC). This book broadens the 'migration' agenda beyond the boundaries of migration studies and migration policy silos. This book is intended to become a resource for a range of audiences in Southern Africa and the continent.

Around the world, countries are becoming urbanized at an astonishing pace. As countries develop economically, their economies shift from mainly rural and agrarian to increasingly urban and nonagricultural. This rural-urban transformation presents both opportunities and challenges for development. When managed effectively, the transformation spurs growth and reduces poverty. When managed poorly, however, the process can result in stark welfare disparities, the marginalization of entire regions, and poorly functioning cities that fail to realize the potential gains from agglomeration economies. This book investigates the rural-urban transformation underway in Sub-Saharan Africa and South Asia, emphasizing the influence of country conditions as well as the potential of good policies to minimize disparities and ensure that everyone shares in the benefits of urbanization. The first part of this book investigates urbanization and rural-urban welfare inequalities on three geographic scales global, national, and local featuring countries and cities in Sub-Saharan Africa on the national and local levels. The second part of the book sheds light on the texture of transformation in five countries in South Asia, each at a different stage in the process: Bangladesh, India, Nepal, Pakistan, and Sri Lanka.

HIV/AIDS reverses life expectancy gains, erodes productivity, consumes savings and dilutes growth efforts, threatening the realization of the Millennium Development Goals (MDGs) in Africa.The report is the result of an extensive analytical and consultative process begun in 2006, that engaged more than 1,000 people from over 30 countries and many.

Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the plasma membrane. These features have made PS-externalization a well-explored phenomenon to image cell death for diagnostic purposes. In addition, it was demonstrated that under certain conditions viable cells express PS at their surface such as endothelial cells of tumor blood vessels, stressed tumor cells and hypoxic cardiomyocytes. Hence, PS has become a potential target for therapeutic strategies aiming at Targeted Drug Delivery. In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes. We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface.

One of the ultimate goals in transplantation is to develop novel therapeutic methods for induction of donor-specific tolerance to reduce the side effects caused by the generalized immunosuppression associated to the currently used pharmacologic regimens. Interaction or phagocytosis of cells in early apoptosis exerts potent anti-inflammatory and immunosuppressive effects on antigen (Ag)-presenting cells (APC) like dendritic cells (DC) and macrophages. This observation led to the idea that apoptotic cell-based therapies could be employed to deliver donor-Ag in combination with regulatory signals to recipient's APC as therapeutic approach to restrain the anti-donor response. This review describes the multiple mechanisms by which apoptotic cells down-modulate the immuno-stimulatory and pro-inflammatory functions of DC and macrophages, and the role of the interaction between apoptotic cells and APC in self-tolerance and in apoptotic cell-based therapies to prevent/treat allograft rejection and graft-versus-host disease in murine experimental systems and in humans. It also explores the role that in vivo-generated apoptotic cells could have in the beneficial effects of extracorporeal photopheresis, donor-specific transfusion, and tolerogenic DC-based therapies in transplantation.

La planificación de los procesos de transición de los y las jóvenes con discapacidad es recogida por la literatura como uno de los aspectos más complejos a los que se enfrenta el sistema educativo. En la actualidad, el reto de estos programas educativos es identificar buenas prácticas que permitan la consecución de resultados de vida adulta valorados. Por tanto, la finalidad de este estudio es definir un marco de actuación desde el que analizar y orientar las prácticas de estos programas para la transición. Para ello, en base a una propuesta global en la que identifican siete grandes dimensiones de buenas prácticas de los programas de transición, el objetivo es, en primer lugar, revisar la literatura en relación a cada una de estas dimensiones sintetizando los componentes principales e implicaciones para su desarrollo y, en segundo lugar, destacar aspectos clave para la respuesta desde los programas educativos. Los resultados muestran que se identifican orientaciones y recomendaciones para el desarrollo de cada una de las dimensiones, así como obstáculos y dificultades que se derivan de la experiencia, concluyendo puntos de partida y aspectos a tener en cuenta a través de los distintos servicios y los diversos agentes.

This report aims to show how macroeconomic policies create differential opportunities for women and men. This volume comprises nine chapters covering four broad themes: gender as a category of analysis in macroeconomics; the implications of gender for macroeconomic aggregates, in particular consumption and economic growth; the role of gender in the labor market, globalization, and access to credit; and gender budgeting. Chapters one and two address the first theme. Chapter one focuses on the macroeconomic cost to growth and development that arises from rigid gender roles and associated gender asymmetries. Chapter two documents the progress made in gender mainstreaming by highlighting developments in data collection and monitoring that have moved beyond simply disaggregating data by male and female. Chapters three and four cover the second theme. Chapter three considers the role of gender relations in the macroeconomic aggregates of consumption, savings, investment, and government expenditure and the implications for macroeconomic policy in these areas. Chapter four examines gender relations and economic growth. Chapters five through seven focus on the third theme. Chapter five examines the labor market. Chapter six examines how globalization affects gender relations, particularly employment. Chapter seven concentrates on women's access to finance and documents gender asymmetries in this market. Chapter eight, on the fourth theme, highlights the impact fiscal policies have on gender relations. It documents how policy can be made more gender specific and reports on the progress made by countries that have adopted gender-responsive government budgeting. Chapter nine summarizes what is known about gender and macroeconomic policy, noting areas in which the literature is well developed as well as areas that require further research and study.

Following a Marxist and, more specifically, a global capitalism perspective, this paper outlines the peculiar characteristics of tourism to argue that the recent developments of this sector have prominently contributed to the transnational integration and global accumulation of capital. These developments are explored by using a Marxist conceptual framework, including class and value relations, within a broader ecological context. Taking into account the particular pattern of development and rapid growth of tourism in recent decades, we examine the implications for the uneven and combined development of global capitalism. More specifically, we examine whether the growth of tourism may sufficiently counteract the global over-accumulation crisis, as well as the particular ways in which capital can extract and appropriate rent from tourism. It is broadly argued that the development of tourism tends to increase the unevenness, as well as the inequalities and the instability, of global capitalism and while it seems to apparently relax the current over-accumulation crisis, it rather tends to further exacerbate the unfolding socio-ecological crisis.

The existence of corruption threatens all aspect of a society, be that social, economic or political. Corruption is more pronounced in developing countries; however, it attracts very little attention from decision-makers. This paper analyses the social implications (health and education) of corruption in India and Pakistan. According to the Corruption Perception Index Report (2019), these countries are perceived to be the most corrupt ones.Corruption has been researched enormously with respect to its economic and political consequences, but not much attention has been given to its social implications on human rights. Corruption violates human rights directly or indirectly. Therefore, this paper aims to elaborate the links (direct and indirect) between corruption and human rights and focus on the consequences of corruption on health and education; it also aims to present anti-corruption policies to curb corruption in the investigated countries.The research employs a systematic literature review method (PRISMA-P 2015) that identifies currently available research, selects and assesses contribution, analyses and synthesises data, and presents pieces of evidence with a justified conclusion. It also encourages researchers to apply PRISMA protocols in future researches.The results show that more than 80% of the reviewed articles argue that corruption is one of the invincible reasons for the people's dire social condition in India and Pakistan; moreover, corruption remains ignored, which shows that there are gaps to understand how corruption can extremely dent the right to education and health.