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Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors
The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the automated segmentation of amygdalar nuclei and hippocampal subfields across sites and vendors using FreeSurfer in two independent cohorts of older and younger healthy adults.
Sixty-five healthy older (cohort 1) and 68 younger subjects (cohort 2), from the PharmaCog and CoRR consortia, underwent repeated 3D-T1 MRI (interval 1–90 days). Segmentation was performed using FreeSurfer v6.0. Reliability was assessed using volume reproducibility error (ε) and spatial overlapping coefficient (DICE) between test and retest session.
Significant MRI site and vendor effects (p < .05) were found in a few subfields/nuclei for the ε, while extensive effects were found for the DICE score of most subfields/nuclei. Reliability was strongly influenced by volume, as ε correlated negatively and DICE correlated positively with volume size of structures (absolute value of Spearman’s r correlations >0.43, p < 1.39E-36). In particular, volumes larger than 200 mm3 (for amygdalar nuclei) and 300 mm3 (for hippocampal subfields, except for molecular layer) had the best test-retest reproducibility (ε < 5% and DICE > 0.80).
Our results support the use of volumetric measures of larger amygdalar nuclei and hippocampal subfields in multisite MRI studies. These measures could be useful for disease tracking and assessment of efficacy in drug trials.
•Differences in MRI site/vendor had a limited effect on volume reproducibility.•Differences in MRI site/vendor had an extensive effect on spatial accuracy.•Reliability is good for larger amygdalar and hippocampal structures.•Automated volumetry is reliable in multicenter MRI studies.
Journal Article
Practical Image and Video Processing Using MATLAB
UP-TO-DATE, TECHNICALLY ACCURATE COVERAGE OF ESSENTIAL TOPICS IN IMAGE AND VIDEO PROCESSING
This is the first book to combine image and video processing with a practical MATLAB®-oriented approach in order to demonstrate the most important image and video techniques and algorithms. Utilizing minimal math, the contents are presented in a clear, objective manner, emphasizing and encouraging experimentation.
The book has been organized into two parts. Part I: Image Processing begins with an overview of the field, then introduces the fundamental concepts, notation, and terminology associated with image representation and basic image processing operations. Next, it discusses MATLAB® and its Image Processing Toolbox with the start of a series of chapters with hands-on activities and step-by-step tutorials. These chapters cover image acquisition and digitization; arithmetic, logic, and geometric operations; point-based, histogram-based, and neighborhood-based image enhancement techniques; the Fourier Transform and relevant frequency-domain image filtering techniques; image restoration; mathematical morphology; edge detection techniques; image segmentation; image compression and coding; and feature extraction and representation.
Part II: Video Processing presents the main concepts and terminology associated with analog video signals and systems, as well as digital video formats and standards. It then describes the technically involved problem of standards conversion, discusses motion estimation and compensation techniques, shows how video sequences can be filtered, and concludes with an example of a solution to object detection and tracking in video sequences using MATLAB®.
Extra features of this book include:
* More than 30 MATLAB® tutorials, which consist of step-by-step guides toexploring image and video processing techniques using MATLAB®
* Chapters supported by figures, examples, illustrative problems, and exercises
* Useful websites and an extensive list of bibliographical references
This accessible text is ideal for upper-level undergraduate and graduate students in digital image and video processing courses, as well as for engineers, researchers, software developers, practitioners, and anyone who wishes to learn about these increasingly popular topics on their own.
eBook
2-D and 3-D image registration
To master the fundamentals of image registration, there is no more comprehensive source than 2-D and 3-D Image Registration. In addition to delving into the relevant theories of image registration, the author presents their underlying algorithms. You'll also discover cutting-edge techniques to use in remote sensing, industrial, and medical applications. Examples of image registration are presented throughout, and the companion Web site contains all the images used in the book and provides links to software and algorithms discussed in the text, allowing you to reproduce the results in the text and develop images for your own research needs. 2-D and 3-D Image Registration serves as an excellent textbook for classes in image registration as well as an invaluable working resource.
eBook
Biomedical Signal Analysis - Contemporary Methods and Applications
This book describes a broad range of methods, including continuous and discrete Fourier transforms, independent component analysis (ICA), dependent component analysis, neural networks, and fuzzy logic methods. The book then discusses applications of these theoretical tools to practical problems in everyday biosignal processing, considering such subjects as exploratory data analysis and low-frequency connectivity analysis in MRI, MRI signal processing including lesion detection in breast MRI, dynamic cerebral contrast-enhanced perfusion MRI, skin lesion classification, and microscopic slice image processing and automatic labeling.
eBook
Computer vision and imaging in intelligent transportation systems
This reference provides readers with an overview of how computer vision can contribute to the different applications in the field of road transportation. It presents a survey of computer vision techniques related to three key broad problems in the roadway transportation domain: safety, efficiency, and law enforcement. The individual chapters present significant applications within those problem domains, each presented in a tutorial manner, describing the motivation for and benefits of the application, and a description of the state of the art.
Book
Fundamentals of light microscopy and electronic imaging
Fundamentals of Light Microscopy and Electronic Imaging, Second Edition provides a coherent introduction to the principles and applications of the integrated optical microscope system, covering both theoretical and practical considerations.
eBook