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The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds of proteins that interact with the mineral phase controlling its formation and structural organization, and thus determine the mechanical properties of the mature biomaterial. We describe its mineralogy, structure and the regulatory interactions that integrate the mineral and organic constituents. We underline recent evidence for vesicular transfer of amorphous calcium carbonate (ACC), as a new pathway to ensure the active and continuous supply of the ions necessary for shell mineralization. Currently more than 900 proteins and thousands of upregulated transcripts have been identified during chicken eggshell formation. Bioinformatic predictions address their functionality during the biomineralization process. In addition, we describe matrix protein quantification to understand their role during the key spatially- and temporally- regulated events of shell mineralization. Finally, we propose an updated scheme with a global scenario encompassing the mechanisms of avian eggshell mineralization. With this large dataset at hand, it should now be possible to determine specific motifs, domains or proteins and peptide sequences that perform a critical function during avian eggshell biomineralization. The integration of this insight with genomic data (non-synonymous single nucleotide polymorphisms) and precise phenotyping (shell biomechanical parameters) on pure selected lines will lead to consistently better-quality eggshell characteristics for improved food safety. This information will also address the question of how the evolutionary-optimized chicken eggshell matrix proteins affect and regulate calcium carbonate mineralization as a good example of biomimetic and bio-inspired material design.

Cloud enterprise resource planning (Cloud ERP) provides an efficient big data management solution for lithium-ion battery (LiB) enterprises. However, in the open ecological environment, Cloud ERP makes the LiB supply chain face multi-user and multi-subject interactions, which can generate sensitive data and privacy data security issues (such as user override access behavior). In this study, we take the value and information interaction into account to examine the user behaviors of the diverse stakeholders in the LiB supply chain. Therefore, a user behavior monitoring algorithm (UBMA), different from the mainstream supervised algorithms and unsupervised learning algorithms, is proposed to monitor the unsafe behaviors that may threaten data privacy in Cloud ERP. The results show that the UBMA can accurately search out the user behavior sequence where the unsafe behavior is located from a large amount of user behavior information, which reduces the complexity of directly identifying the unsafe behavior. In addition, compared with the recursive unsupervised binary classification method, the UBMA model has a lower resource consumption and higher efficiency. In addition, the UBMA has great flexibility. The UBMA can be further updated and extended by re-establishing the statistical characteristics of the standard user behavior fields to quickly adapt to user changes and function upgrades in the LiB supply chain.

Wetland fringe areas in prairie agricultural landscapes may be subjected to burning of vegetation in autumn followed by cultivation in spring. The objective of this study was to examine the greenhouse gas (CO₂, N₂O and CH₄) emissions and plant nutrient (NO₃, PO₄ and SO₄) supplies in wetland fringe soils as affected by simulated burning + cultivation, at field capacity and saturation moisture content. Using undisturbed soil cores collected from grassed wetland fringes at four sites in southern Saskatchewan, the impacts were examined over a 20-day period. The burning + cultivation treatment generally reduced CO₂ emissions, tended to increase NO₃-N availability, and had no consistent effect on N₂O emissions, or PO₄-P and SO₄-S supply. Production of CH₄ occurred only at one site, and only under saturated conditions. Compared to field capacity, saturation reduced CO₂ emissions and NO₃-N supply, tended to increase PO₄-P availability, and had no consistent effect on N₂O emissions and SO₄-S. The CO₂ emissions and SO₄-S were greater for soil cores with higher organic matter and salinity, respectively. The N₂O emissions were only occasionally related to soil NO₃-N supply rate.

The contribution of this paper is putting forward a kind of ion accelerator magnet excitation power supply with bidirectional reduced matrix converter (BRMC) as well as a coordination control strategy with bipolar current space vector modulation strategy, which is utilized to realize bidirectional power flow for a BRMC system to solve problems such as low input power factor, large input current harmonics and no bidirectional energy in the conventional ion accelerator magnet excitation power supply. Meanwhile, a hybrid commutation strategy combining the simplified three-step commutation with zero vector commutation was proposed to solve the commutation problem for a matrix-type first stage in BRMC. The feasibility and effectiveness of the proposed strategy, which can achieve bidirectional energy flow and safer commutation, have been verified by the experimental results.

The heating neutral beam injectors (HNBs) of ITER are designed to deliver 16.7 MW of 1 MeV D0 or 0.87 MeV H0 to the ITER plasma for up to 3600 s. They will be the most powerful neutral beam (NB) injectors ever, delivering higher energy NBs to the plasma in a tokamak for longer than any previous systems have done. The design of the HNBs is based on the acceleration and neutralisation of negative ions as the efficiency of conversion of accelerated positive ions is so low at the required energy that a realistic design is not possible, whereas the neutralisation of H− and D− remains acceptable ( 56%). The design of a long pulse negative ion based injector is inherently more complicated than that of short pulse positive ion based injectors because: negative ions are harder to create so that they can be extracted and accelerated from the ion source; electrons can be co-extracted from the ion source along with the negative ions, and their acceleration must be minimised to maintain an acceptable overall accelerator efficiency; negative ions are easily lost by collisions with the background gas in the accelerator; electrons created in the extractor and accelerator can impinge on the extraction and acceleration grids, leading to high power loads on the grids; positive ions are created in the accelerator by ionisation of the background gas by the accelerated negative ions and the positive ions are back-accelerated into the ion source creating a massive power load to the ion source; electrons that are co-accelerated with the negative ions can exit the accelerator and deposit power on various downstream beamline components. The design of the ITER HNBs is further complicated because ITER is a nuclear installation which will generate very large fluxes of neutrons and gamma rays. Consequently all the injector components have to survive in that harsh environment. Additionally the beamline components and the NB cell, where the beams are housed, will be activated and all maintenance will have to be performed remotely. This paper describes the design of the HNB injectors, but not the associated power supplies, cooling system, cryogenic system etc, or the high voltage bushing which separates the vacuum of the beamline from the high pressure SF6 of the high voltage (1 MV) transmission line, through which the power, gas and cooling water are supplied to the beam source. Also the magnetic field reduction system is not described.

HighlightsFundamental rationalisation for high-energy batteries.Newly emerging and the state-of-the-art high-energy batteries vs. incumbent lithium-ion batteries: performance, cost and safety.Closing the gap between academic research and commercialisation of emerging high-energy batteries, and examination of the remaining challenges.Rechargeable batteries of high energy density and overall performance are becoming a critically important technology in the rapidly changing society of the twenty-first century. While lithium-ion batteries have so far been the dominant choice, numerous emerging applications call for higher capacity, better safety and lower costs while maintaining sufficient cyclability. The design space for potentially better alternatives is extremely large, with numerous new chemistries and architectures being simultaneously explored. These include other insertion ions (e.g. sodium and numerous multivalent ions), conversion electrode materials (e.g. silicon, metallic anodes, halides and chalcogens) and aqueous and solid electrolytes. However, each of these potential “beyond lithium-ion” alternatives faces numerous challenges that often lead to very poor cyclability, especially at the commercial cell level, while lithium-ion batteries continue to improve in performance and decrease in cost. This review examines fundamental principles to rationalise these numerous developments, and in each case, a brief overview is given on the advantages, advances, remaining challenges preventing cell-level implementation and the state-of-the-art of the solutions to these challenges. Finally, research and development results obtained in academia are compared to emerging commercial examples, as a commentary on the current and near-future viability of these “beyond lithium-ion” alternatives.

Graphitic carbon nitride (g‐C3N4) is a highly recognized two‐dimensional semiconductor material known for its exceptional chemical and physical stability, environmental friendliness, and pollution‐free advantages. These remarkable properties have sparked extensive research in the field of energy storage. This review paper presents the latest advances in the utilization of g‐C3N4 in various energy storage technologies, including lithium‐ion batteries, lithium‐sulfur batteries, sodium‐ion batteries, potassium‐ion batteries, and supercapacitors. One of the key strengths of g‐C3N4 lies in its simple preparation process along with the ease of optimizing its material structure. It possesses abundant amino and Lewis basic groups, as well as a high density of nitrogen, enabling efficient charge transfer and electrolyte solution penetration. Moreover, the graphite‐like layered structure and the presence of large π bonds in g‐C3N4 contribute to its versatility in preparing multifunctional materials with different dimensions, element and group doping, and conjugated systems. These characteristics open up possibilities for expanding its application in energy storage devices. This article comprehensively reviews the research progress on g‐C3N4 in energy storage and highlights its potential for future applications in this field. By exploring the advantages and unique features of g‐C3N4, this paper provides valuable insights into harnessing the full potential of this material for energy storage applications. This review serves as a comprehensive guide, shedding light on the promising advances and future prospects of utilizing graphitic carbon nitride (g‐C3N4) in energy storage devices. By examining the distinctive features and capabilities of g‐C3N4, this paper not only provides valuable insights but also paves the way for further exploration and innovation in the realm of multifunctional materials for energy storage.

Carbon‐based nanomaterials, including graphene, fullerenes, and carbon nanotubes, are attracting significant attention as promising materials for next‐generation energy storage and conversion applications. They possess unique physicochemical properties, such as structural stability and flexibility, high porosity, and tunable physicochemical features, which render them well suited in these hot research fields. Technological advances at atomic and electronic levels are crucial for developing more efficient and durable devices. This comprehensive review provides a state‐of‐the‐art overview of these advanced carbon‐based nanomaterials for various energy storage and conversion applications, focusing on supercapacitors, lithium as well as sodium‐ion batteries, and hydrogen evolution reactions. Particular emphasis is placed on the strategies employed to enhance performance through nonmetallic elemental doping of N, B, S, and P in either individual doping or codoping, as well as structural modifications such as the creation of defect sites, edge functionalization, and inter‐layer distance manipulation, aiming to provide the general guidelines for designing these devices by the above approaches to achieve optimal performance. Furthermore, this review delves into the challenges and future prospects for the advancement of carbon‐based electrodes in energy storage and conversion. Carbon‐based nanomaterials, including graphene, fullerenes, and carbon nanotubes, are among the most rapidly emerging building blocks for nanotechnologies. This review elucidates the advantages and the crucial role of these family materials and summarizes the prevailing strategies for achieving high‐performance energy storage and conversion applications.

Mechanosensitive channels sense mechanical forces in cell membranes and underlie many biological sensing processes 1 – 3 . However, how exactly they sense mechanical force remains under investigation 4 . The bacterial mechanosensitive channel of small conductance, MscS, is one of the most extensively studied mechanosensitive channels 4 – 8 , but how it is regulated by membrane tension remains unclear, even though the structures are known for its open and closed states 9 – 11 . Here we used cryo-electron microscopy to determine the structure of MscS in different membrane environments, including one that mimics a membrane under tension. We present the structures of MscS in the subconducting and desensitized states, and demonstrate that the conformation of MscS in a lipid bilayer in the open state is dynamic. Several associated lipids have distinct roles in MscS mechanosensation. Pore lipids are necessary to prevent ion conduction in the closed state. Gatekeeper lipids stabilize the closed conformation and dissociate with membrane tension, allowing the channel to open. Pocket lipids in a solvent-exposed pocket between subunits are pulled out under sustained tension, allowing the channel to transition to the subconducting state and then to the desensitized state. Our results provide a mechanistic underpinning and expand on the ‘force-from-lipids’ model for MscS mechanosensation 4 , 11 . The authors report the structural characterization of the mechanically activated channel MscS in different membrane environments and show how the mechanosensation of MscS can be visualized.

Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” that causes leakage of protein-rich plasma and pulmonary edema. However, little is known about vascular endothelial sensing and transduction of mechanical stimuli inducing endothelial barrier disruption. Piezo1, a mechanosensing ion channel expressed in endothelial cells (ECs), is activated by elevated pressure and other mechanical stimuli. Here, we demonstrate the involvement of Piezo1 in sensing increased lung microvessel pressure and mediating endothelial barrier disruption. Studies were made in mice in which Piezo1 was deleted conditionally in ECs (Piezo1iΔEC), and lung microvessel pressure was increased either by raising left atrial pressure or by aortic constriction. We observed that lung endothelial barrier leakiness and edema induced by raising pulmonary microvessel pressure were abrogated in Piezo1iΔEC mice. Piezo1 signaled lung vascular hyperpermeability by promoting the internalization and degradation of the endothelial adherens junction (AJ) protein VE-cadherin. Breakdown of AJs was the result of activation of the calcium-dependent protease calpain and degradation of the AJ proteins VE-cadherin, β-catenin, and p120-catenin. Deletion of Piezo1 in ECs or inhibition of calpain similarly prevented reduction in the AJ proteins. Thus, Piezo1 activation in ECs induced by elevated lung microvessel pressure mediates capillary stress failure and edema formation secondary to calpain-induced disruption of VE-cadherin adhesion. Inhibiting Piezo1 signaling may be a useful strategy to limit lung capillary stress failure injury in response to elevated vascular pressures.