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result(s) for
"Iridocyclitis - drug therapy"
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Overview of Cytomegalovirus Ocular Diseases: Retinitis, Corneal Endotheliitis, and Iridocyclitis
by
Kobayashi, Reiko
,
Hashida, Noriyasu
in
Acquired immune deficiency syndrome
,
acquired immunodeficiency syndrome
,
Adsorption
2024
Cytomegalovirus (CMV) infection is a significant clinical concern in newborns, immunocompromised patients with acquired immunodeficiency syndrome (AIDS), and patients undergoing immunosuppressive therapy or chemotherapy. CMV infection affects many organs, such as the lungs, digestive organs, the central nerve system, and eyes. In addition, CMV infection sometimes occurs in immunocompetent individuals. CMV ocular diseases includes retinitis, corneal endotheliitis, and iridocyclitis. CMV retinitis often develops in infected newborns and immunocompromised patients. CMV corneal endotheliitis and iridocyclitis sometimes develop in immunocompetent individuals. Systemic infections and CMV ocular diseases often require systemic treatment in addition to topical treatment.
Journal Article
Micro‐Focused Ultrasound Treatment for Periocular Skin Leading to Corneal Leukoma With Iridocyclitis: A Case Report
by
Liu, Jie
,
Li, Ni
,
Luo, Hongmei
in
Adult
,
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
,
Blood vessels
2025
Background Micro‐focused ultrasound (MFUS) converts the mechanical energy of high‐frequency vibrations into thermal energy and induces collagen remodeling through thermal effects to achieve skin tightening and lifting. However, when employed for periocular skin treatment, MFUS carries a potential risk of ocular injury, which deserves high attention from cosmetic surgeons. Aims This article reports a case of a young female patient who developed transient visual acuity decline with iridocyclitis and residual corneal leukoma after MFUS treatment on the periocular skin. Patient A 32‐year‐old female patient underwent facial MFUS treatment at a cosmetic clinic to improve facial skin laxity. During the treatment of the right periocular skin, the patient developed right eye pain and visual acuity decline. The patient was treated with nonsteroidal anti‐inflammatory drugs (NSAIDs) and glucocorticoids in the right eye and followed up for 3 months. The visual acuity of the right eye improved, but a permanent corneal leukoma persisted. Results While MFUS treatment targeting the periorbital area can improve skin laxity, it poses a risk of corneal injury and iridocyclitis. After the treatment, the iridocyclitis resolved, but a permanent corneal leukoma remained. Conclusions Periocular MFUS treatment carries the risk of irreversible thermal damage to ocular tissues. Cosmetic surgeons must strictly determine the intensity threshold for periocular MFUS and ensure proper application of eye‐protective devices.
Journal Article
The outcome of initial mitomycin C-augmented trabeculectomy with subconjunctival bevacizumab in the management of secondary glaucoma associated with Fuchs heterochromic iridocyclitis
2020
PurposeTo investigate the outcome of mitomycin C (MMC)-augmented trabeculectomy with subconjunctival bevacizumab in the management of Fuchs heterochromic iridocyclitis (FHI)-related glaucoma in 1-year follow-up period.MethodsThis retrospective study included 50 eyes with FHI-related glaucoma those had underwent initial trabeculectomy with MMC (0.2 mg/ml—3 min). Thirty-one of them had single-dose bevacizumab injection (1.25 mg/0.05 ml) into the bleb area just at the end of the surgery, while 19 eyes did not have. The intraocular pressure (IOP) and the mean number of anti-glaucomatous medications were evaluated. The IOP value ≤ 21 mmHg was defined as complete or qualified surgical success in terms of using medical anti-glaucomatous treatment. Bleb height and vascularity were evaluated with Indiana bleb grading system. Paired sample t test, t test, Chi-square and Kolmogorov–Smirnov tests were used for statistical analysis.ResultsThe preoperative IOP values of bevacizumab and without bevacizumab groups were 32.8 ± 4.5 mmHg and 32.8 ± 4.5 mmHg, respectively, and they decreased to 17.5 ± 4.6 mmHg and 17 ± 5.2 mmHg at the final visit (p < 0.001 for all values). There were no significant differences in postoperative IOP and the number of medications between the groups at the final visit. In bevacizumab group, complete success was achieved in 100% within the third month but decreased to 22.5% (complete) and 74.1% (qualified) at the first year. In the other group (without bevacizumab group), complete success was achieved in 94.7% within the third month but decreased to 15.8% (complete) and 84.2% (qualified) at the first year.ConclusionInitial trabeculectomy with MMC and subconjunctival bevacizumab injection was found to have lower rates of complete success with relatively acceptable qualified success rates in the management of FHI-related glaucoma. Subconjunctival bevacizumab was not found to have additional effect to improve the surgical success.
Journal Article
Bullous central serous chorioretinopathy and retinal pigment epithelium sequelae postblunt trauma
by
Gunna, Nithin Teja
,
C Parameswarappa, Deepika
,
Rani, Padmaja Kumari
in
Administration, Ophthalmic
,
Aged
,
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
2020
A 68-year-old man presented with diminution of distance and near vision in the right eye for a duration of 1 month postblunt trauma with a stick. On examination, his visual acuity in the right eye was 20/320 and near vision was
Journal Article
Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis
2006
Aim: To describe the diagnostic and therapeutic management of cytomegalovirus (CMV) anterior uveitis unassociated with retinal necrosis in immunocompetent patients. Methods: Patients referred between 2001 and 2003 for management of unilateral, chronic, recurrent uveitis associated with secondary glaucoma underwent extensive investigation including laboratory tests for herpes virus infections. Specific antiviral treatment was initiated in all cases and the level of ocular inflammation was evaluated during the follow up. Results: Five patients, three men and two women, were included. Median age was 50 years old (range 30–80 years). Anterior unilateral uveitis without iris atrophy was observed in all cases. Uveitis was chronic in three cases and recurrent in two cases. Glaucoma was observed in all patients with a median intraocular pressure of 30 mm Hg (range 22–43 mm Hg). Five patients responded initially to specific anti-CMV therapy. Even though glaucoma surgery was necessary in two cases, both ocular inflammation and glaucoma were controlled in all cases. Relapses occurred in three cases after cessation of therapy, requiring prolonged maintenance therapy with valganciclovir. Conclusions: CMV infection and specific antiviral therapy should be considered in all cases of relapsing or chronic iridocyclitis and secondary glaucoma. Maintenance regimens of valganciclovir may be necessary to prevent further relapses.
Journal Article
Ocular toxicity by latex of Calotropis procera (Sodom apple)
by
Bhaumik, Arup
,
Mohanta, Ayan
,
Basak, SamarK
in
Adult
,
Aged
,
Antihypertensive Agents - therapeutic use
2009
We report the spectrum of ocular toxicity following accidental inoculation of latex of Calotropis procera (Sodom apple) in 29 eyes between January 2003 and December 2006. All patients presented with sudden painless dimness of vision with photophobia. Twenty-five (86%) patients had initial visual acuity of less than 20/60. All eyes had conjunctival congestion and mild to severe corneal edema with Descemet's folds. Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma. After treatment with topical corticosteroids, antiglaucoma agents, cycloplegics, hypertonic saline and tears supplements, 27 (93%) eyes recovered completely within 3-14 days. After three months, 17 (74%) out of 23 eyes showed a significant low endothelial cell count compared to the normal fellow eye ( P 0.001). The latex of Calotropis procera causes significant ocular morbidity which may be preventable by simple health education. The long-term effect on corneal endothelium has to be studied further.
Journal Article
Fuchs’ heterochromic cyclitis: a post-infectious manifestation of ocular toxoplasmosis?
by
Céline, Terrada
,
Jad, Akesbi
,
Nathalie, Cassoux
in
Adrenal Cortex Hormones - therapeutic use
,
Adult
,
Anti-Infective Agents - therapeutic use
2013
The purpose of this article is to report the development of Fuchs’ heterochromic cyclitis (FHC) secondary to toxoplasmosis chorioretinitis. The design is based on observational case series report. We report in this article six cases of typical FHC developing secondary to ocular toxoplasmosis. Intraocular immunoglobulin G production against
Toxoplasma gondii
was determined in the aqueous humor of five patients by calculation of the Goldmann–Witmer coefficient (GWC). The clinical examination revealed typical FHC with no active chorioretinal scar. We report on five women and one man (aged 33–64 years old; median 44.6 years) who developed FHC over a period of time ranging from 2–13 years. A positive GWC (>3) was found in four patients; of the two remaining patients one was negative and the other did not have anterior chamber paracentesis. Four patients were treated for an active ocular toxoplasmic lesion before the development of FHC with pyrimethamine, sulfadiazine and corticosteroids. Two patients had negative anti-toxoplasmic therapy for FHC (one with trimethoprim-sulfamethoxazole for 3 weeks and the other with pyrimethamine, sulfadiazine and corticosteroids for 8 weeks). One never had any treatment. All the patients had mild anterior chamber reaction with no synechia, diffuse and characteristic white stellate keratic precipitates and vitritis; five patients had posterior subcapsular cataract and heterochromia and three had elevated intraocular pressure. The findings help us to conclude that FHC can develop over a period of time after ocular toxoplasmosis. This could be a main association to search for when a Fuchs’ uveitis is found with a chorioretinal scar. Ocular inflammation does not mean reactivation of ocular toxoplasmosis. FHC could be a secondary immune reaction with a past antigenic stimulation to a previous infection, i.e., toxoplasmosis, etc.
Journal Article
Isolated oculocutaneous sarcoidosis in a teenage male: a rare case report
by
Jain, D.
,
Mittal, A.
,
Dabas, G.
in
Administration, Cutaneous
,
Adolescent
,
Diagnosis, Differential
2016
Sarcoidosis is an inflammatory disease with multisystem involvement characterized by the presence of noncaseating granulomas. It can affect virtually every organ of the body, with lung involvement being most common occurring in >90% of patients. Other organs affected are skin, eye and liver. Skin involvement is common, affecting 25-35%. Here we present a rare case of a 15 year-old male with isolated oculocutaneous sarcoidosis without systemic involvement.
Journal Article
Cat-Scratch Disease (Ocular Bartonellosis) Presenting as Bilateral Recurrent Iridocyclitis
by
Torres, Jenice
,
Calonge, Margarita
,
Martínez-Osorio, Hernán
in
Anti-Bacterial Agents - therapeutic use
,
Bartonella henselae - isolation & purification
,
Cat-Scratch Disease - diagnosis
2005
An otherwise healthy 9-year-old girl presented with bilateral recurrent anterior uveitis. Thirteen months later, the diagnosis of cat-scratch disease (ocular bartonellosis) was suspected when neuroretinitis appeared. Confirmation was based on serological test results positive for Bartonella henselae. Antibiotic treatment completely cured the disease, and there have been no further manifestations during a follow-up period of 6 years.
Journal Article
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