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The “isomorphic subtype of diffuse astrocytoma” was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas. Immunohistochemically, they were GFAP-positive, MAP2-, OLIG2- and CD34-negative, nuclear ATRX-expression was retained and proliferation was low. All 24 cases sequenced were IDH-wildtype. In cluster analyses of DNA methylation data, isomorphic diffuse gliomas formed a group clearly distinct from other glial/glio-neuronal brain tumours and normal hemispheric tissue, most closely related to paediatric MYB/MYBL1 -altered diffuse astrocytomas and angiocentric gliomas. Half of the isomorphic diffuse gliomas had copy number alterations of MYBL1 or MYB (13/25, 52%). Gene fusions of MYBL1 or MYB with various gene partners were identified in 11/22 (50%) and were associated with an increased RNA-expression of the respective MYB -family gene. Integrating copy number alterations and available RNA sequencing data, 20/26 (77%) of isomorphic diffuse gliomas demonstrated MYBL1 (54%) or MYB (23%) alterations. Clinically, 89% of patients were seizure-free after surgery and all had a good outcome. In summary, we here define a distinct benign tumour class belonging to the family of MYB/MYBL1 -altered gliomas. Isomorphic diffuse glioma occurs both in children and adults, has a concise morphology, frequent MYBL1 and MYB alterations and a specific DNA methylation profile. As an exclusively histological diagnosis may be very challenging and as paediatric MYB/MYBL1 -altered diffuse astrocytomas may have the same gene fusions, we consider DNA methylation profiling very helpful for their identification.

PurposeThe need to engage in manufacturing practices that promote environmental sustainability has shifted from being optional to mandatory. From the perspectives of institutional and stakeholder theories, this paper captures the efficacy of isomorphic pressures on the adoption of green procurement, green product and process innovations and their respective influence on organizational legitimacy and financial performance in the context of an emerging economy and from the perspective of manufacturing small-and medium-sized enterprises.Design/methodology/approachThe study adopted a survey research design, a quantitative approach and partial least square structural equation modelling (PLS-SEM) technique in making data analysis and interpretations due to its suitability for predictive research models.FindingsAnalysis of the results highlighted the fact that the composite impact of coercive, mimetic and normative isomorphic pressures robustly influenced the adoption of green procurement, green product and process innovations. Simultaneously, green procurement, green product and process innovations significantly influenced organizational legitimacy. Green procurement and green product innovation also significantly influenced financial performance unlike green process innovation that had an insignificant yet positive impact on financial performance. Based on the results, theoretical and practical implications are explained for policy makers, managers, government authorities and owners.Originality/valueThe study is among the first to expose isomorphic pressures on the adoption of green manufacturing practices specifically, green procurement, green product and process innovations and their influence on organizational legitimacy and financial performance in the context of Ghana, an emerging economy and from the perspective of small-and medium-sized enterprises. As such, the study provides guidance to relevant industry authorities and stakeholders in further promoting green manufacturing practices that preserve the environment by producing safer consumer products through efficient green procurement, green product and process innovative practices.

Interventional surgical robots are widely used in neurosurgery to improve surgeons’ working environment and surgical safety. Based on the actual operational needs of surgeons’ feedback during preliminary in vivo experiments, this paper proposed an isomorphic interactive master controller for the master–slave interventional surgical robot. The isomorphic design of the controller allows surgeons to utilize their surgical skills during remote interventional surgeries. The controller uses the catheter and guidewire as the operating handle, the same as during actual surgeries. The collaborative operational structure design and the working methods followed the clinical operational skills. The linear force feedback and torque feedback devices were designed to improve the safety of surgeries under remote operating conditions. An eccentric force compensation was conducted to achieve accurate force feedback. Several experiments were carried out, such as calibration experiments, master–slave control performance evaluation experiments, and operation comparison experiments on the novel and previously used controllers. The experimental results show that the proposed controller can perform complex operations in remote surgery applications and has the potential for further animal experiment evaluations.

Here we give the notion of L₂−directed topological spaces of directed graphs, and some results about this notion such as Alexandroff property. Next, we study the form of L₂−directed topological space on E-generated subdirected graphs and their relation with the relative topologies. The relations between some fundamental properties in topological spaces with their corresponding properties in graphs such as the isomorphically and connectedness are introduced.

Morphea is an inflammatory, sclerosing skin condition of unknown cause that generally does not present systemic manifestations. A 66-year-old Caucasian Peruvian female patient, who was previously a nurse, presented with a prior history of 4 years of indurated dermal plaque lesions with constant progression. Diagnosis of morphea was made by clinical examination and skin biopsy. The patient started topical treatment with methoxsalen and phototherapy. When no improvement was seen, it was switched to methotrexate. However, due to changes in liver profile, phototherapy was restarted with progressive clinical improvement. It is essential to differentiate all morphea subtypes for proper management.

In order to investigate the interaction of rubber particles and straw powder coupling on concrete mechanics, the rubber particle mixing, straw powder mixing, and silane coupling agent KH570 modification as the three main factors were compared through a compressive strength test. Results show that when rubber particles were added with 10%, 20%, and 30% volume fractions, the compressive strength of rubber concrete was 42.45 MPa, 36.82 MPa, and 30.25 MPa, respectively, which decreased by 15.4%, 26.6%, and 39.7% compared with ordinary concrete, respectively. And the addition of straw powder also has adverse effects on the compressive strength of concrete. The uniaxial compressive damage constitutive model was proposed for modified recycled rubber-straw powder concrete based on the analysis of the entire compressive stress-strain curve, which fits well with the experimental test data. Furthermore, the numerical simulation of the proposed model is conducted using the FEA software ABAQUS, predicting properties such as compressive strength for modified recycled rubber-straw powder concrete with other admixtures.

Let G ∗ = (V, E) be a simple graph and A be any nonempty set of parameters. Let subset R of A×V be an arbitrary relation from A to V. A mapping from A to ᵖ( V ) written as F:A → ᵖ( V ) can be defined as F(x) = y ∈ V/xRy and a mapping from A to ᵖ(E) written as K:A → ᵖ( E ) can be defined as K(x) = uv ∈ E/u, v ⊆ F(x). The pair (F, A) is a soft set over V and the pair (K, A) is a soft set over E. Obviously (F(a), K(a)) is a subgraph of G ∗ for all a ∈ A. The 4-tuple G = ( G ∗ , F, K, A) is called a soft graph of G. In this paper we discuss different soft graphs of graphs such as Complete graph, Star graph, Complete bipartite graph, Crown graph, Comb graph, Friendship graph, Bistar graph and Wheel graph.

In response to the increasing number of agents and changing task scenarios in multi-agent collaborative systems, existing collaborative strategies struggle to effectively adapt to new task scenarios. To address this challenge, this paper proposes a knowledge distillation method combined with a domain separation network (DSN-KD). This method leverages the well-performing policy network from a source task as the teacher model, utilizes a domain-separated neural network structure to correct the teacher model’s outputs as supervision, and guides the learning of agents in new tasks. The proposed method does not require the pre-design or training of complex state-action mappings, thereby reducing the cost of transfer. Experimental results in scenarios such as UAV surveillance and UAV cooperative target occupation, robot cooperative box pushing, UAV cooperative target strike, and multi-agent cooperative resource recovery in a particle simulation environment demonstrate that the DSN-KD transfer method effectively enhances the learning speed of new task policies and improves the proximity of the policy model to the theoretically optimal policy in practical tasks.

With the increasing concern regarding climate change, academics and practitioners are devoting attention to corporate environmental sustainability development. However, corporate environmental responsibility as an outcome of corporate governance (CG) practice is also constrained by national culture as an institutional factor, and research on the relationship between CG and environmental sustainability performance (ESP) with consideration for national culture remains scarce. Therefore, this study investigates the ESP data of Forbes’ listed multinational corporations (MNCs) through content analysis and applies STATA software with stepwise regression models to empirically test the relationship between CG and MNCs’ ESP and the moderating effects of national culture on this relationship. The results show that board independence and board size positively affect MNCs’ ESP, and the relationship between board independence and MNCs’ ESP is negatively moderated by masculinity and uncertainty avoidance. Our results emphasize the importance of CG in environmental decision-making by board management supervision enhancement and explain how national culture affects ESP because of its influence on CG. Our study explains the agency effect of board composition on MNCs’ environmental sustainability development and the influence of national culture, which establishes a link between CG, ESP, and national culture. Moreover, policymakers and MNCs’ suggestions for enhancing ESP through CG measures, while considering national culture, are also provided.

For a graph G , let τ ( G ) be the maximum number of colors such that there exists an edge-coloring of G with no two color classes being isomorphic. We investigate the behavior of τ ( G ) when G = G ( n , p ) is the classical Erdős-Rényi random graph.