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The current version of the Chief of Naval Operations Professional Reading Program (CNO-PRP) features a dozen titles of relevance to sailors at all ranks within our Navy. One such book, To Rule the Waves, written by Bruce D. Jones, provides a remarkably broad look at how various components of the global maritime enterprise are interconnected and must be understood and appreciated by all maritime professionals. Here, Jackson discusses some of the key points of this outstanding book.

To study essential maternal gene requirements in the early C. elegans embryo, we have screened for temperature-sensitive, embryonic lethal mutations in an effort to bypass essential zygotic requirements for such genes during larval and adult germline development. With conditional alleles, multiple essential requirements can be examined by shifting at different times from the permissive temperature of 15°C to the restrictive temperature of 26°C. Here we describe 24 conditional mutations that affect 13 different loci and report the identity of the gene mutations responsible for the conditional lethality in 22 of the mutants. All but four are mis-sense mutations, with two mutations affecting splice sites, another creating an in-frame deletion, and one creating a premature stop codon. Almost all of the mis-sense mutations affect residues conserved in orthologs, and thus may be useful for engineering conditional mutations in other organisms. We find that 62% of the mutants display additional phenotypes when shifted to the restrictive temperature as L1 larvae, in addition to causing embryonic lethality after L4 upshifts. Remarkably, we also found that 13 out of the 24 mutations appear to be fast-acting, making them particularly useful for careful dissection of multiple essential requirements. Our findings highlight the value of C. elegans for identifying useful temperature-sensitive mutations in essential genes, and provide new insights into the requirements for some of the affected loci.

A likelihood-free estimator of population structure bridging admixture models and principal components analysis, pp. 1009-1029 Irineo Cabreros and John D. Storey Characterizing genetic variation in humans is an important task in statistical genetics, enabling disease-gene mapping in genome-wide association studies (GWAS) and informing studies of human evolutionary history. Fibroblast growth factor receptors function redundantly during zebrafish embryonic development, pp. 1301-1319 Dena M. Leerberg, Rachel E. Hopton, and Bruce W. Draper The fibroblast growth factor (Fgf) signaling pathway has been implicated in many developmental processes, based largely on disruption of Fgf ligand gene functions. Restoration of proteostasis in the endoplasmic reticulum reverses an inflammation-like response to cytoplasmic DNA in Caenorhabditis elegans, pp. 1259-1278 Ashley B. Williams, Felix Heider, Jan-Erik Messling, Matthias Rieckher, Wilhelm Bloch, and Björn Schumacher Caenorhabditis elegans possesses a rudimentary innate immune response that serves as a model for various aspects of the human innate immune response.

\"I think the other BRICS were all in their way quite uncomfortable with Russia's moves in Crimea, but they're also quite uncomfortable with the West using sanctions because they're all quite vulnerable to that political weapon,\" noted [Bruce Jones], author of a just released book on the global order, 'Still Ours to Lead: America, Rising Powers, and the Tension Between Rivalry and Restraint'. \"That goes to the core issue of the BRICS,\" he said. \"They're strategically divided at the same time that they are unified in wanting to resist the West's using its economic leverage to pressure them.\" \"Even though emerging powers are reluctant to align themselves clear with the West on this front, I think that they are for the most part on board with the Western response,\" he said. \"And the fact that so few countries have recognised Russia's annexation of Crimes speaks for itself.\"

\"But valuations are notably more extended then other parts of the world and so I have typically been taking profits from the US.\"

Rasprave o americkoj velikoj strategiji i o mjestu Amerike u suvremenom svijetu najvecim se dijelom odvijaju u okviru konfrontacije neokonzervativizma i liberalnog internacionalizma. U ovom radu prikazana su stajalista autora koji se ne opredjeljuju izmeðu tih dviju dominantnih koncepcija, ali razmatraju iste teme. Unilateralizam i zaokupljenost samo ostvarivanjem vlastitih interesa opasnim smatraju i oni koji misle da Amerika ne bi smjela postati imperij i oni koji misle da ona to vec jest. Umjesto uvjeravanja samih sebe i cijeloga svijeta da su brojne americke intervencije rezultat altruizma i dobrih namjera, potrebno je prihvatiti cinjenicu da je Amerika imperij i suociti se s cijenom njegova odrzavanja.