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"Journal club"
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Early antiviral type I interferon impairs lung metastasis
A preprint by Farias et al. shows that the type I interferon response to respiratory syncytial virus infection reduces lung metastasis of breast cancer in a mouse model.
Journal Article
Resident tissue macrophages maintain intraocular pressure by regulating extracellular matrix homeostasis
A preprint by Liu et al. shows that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure in the steady state.
Journal Article
Omicron entry route
Three recent preprints investigate the entry route of SARS-CoV-2 Omicron variant into host cells and its cellular and host tropism.
Journal Article
Type 1 immune response reduces seizure risk after traumatic brain injury
A preprint by Mroz et al. reports a role for IFNgamma in protecting against seizures after traumatic brain injury.
Journal Article
Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells
A preprint by Laubreton et al. suggests a role for agonist selection and cytokine-driven bystander activation in the differentiation and recruitment of memory-phenotype Ly49+CD8+ T cells.
Journal Article
Neutrophils are dispensable for Shigella control: macrophages take centre stage
A preprint by Eislmayr et al. shows that macrophages rather than neutrophils are a key factor in controlling Shigella infection.
Journal Article
Identifying memory genes in cancer drug tolerance
In this Journal Club, Chakrabarti discusses a method to dissect the molecular architecture of inheritable gene expression (memory) states that mark cells that transition into drug-tolerant persister cells in melanoma.
Journal Article
Podoplanin mediates stromal–immune crosstalk in the lymph node
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
Journal Article
Characterization of the B cell receptor repertoire in melanoma
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resident and circulating B cells in patients with melanoma.
Journal Article
In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery
A preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cell populations in vivo.
Journal Article