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Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?
Receptor tyrosine kinases (RTKs) are modular membrane proteins possessing both well-folded and disordered domains acting together in ligand-induced activation and regulation of post-transduction processes that tightly couple extracellular and cytoplasmic events. They ensure the fine-turning control of signal transmission by signal transduction. Deregulation of RTK KIT, including overexpression and gain of function mutations, has been detected in several human cancers. In this paper, we analysed by in silico techniques the Kinase Insert Domain (KID), a key platform of KIT transduction processes, as a generic macrocycle (KIDGC), a cleaved isolated polypeptide (KIDC), and a natively fused TKD domain (KIDD). We assumed that these KID species have similar structural and dynamic characteristics indicating the intrinsically disordered nature of this domain. This finding means that both polypeptides, cyclic KIDGC and linear KIDC, are valid models of KID integrated into the RTK KIT and will be helpful for further computational and empirical studies of post-transduction KIT events.
Journal Article
At Home with the Holocaust
At Home with the Holocaust examines the relationship between intergenerational trauma and domestic space, focusing on how Holocaust survivors' homes became extensions of their traumatized psyches that their children \"inhabited.\" Analyzing second- and third-generation Holocaust literature—such as Art Spiegelman's Maus, Jonathan Safran Foer's Everything Is Illuminated, Sonia Pilcer's The Holocaust Kid, and Elizabeth Rosner's The Speed of Light—as well as oral histories of children of survivors, Lucas F. W. Wilson's study reveals how the material conditions of survivor-family homes, along with household practices and belongings, rendered these homes as spaces of traumatic transference. As survivors' traumas became imbued in the very space of the domestic, their homes functioned as material archives of their Holocaust pasts, creating environments that, not uncommonly, second-handedly wounded their children. As survivor-family homes were imaginatively transformed by survivors' children into the sites of their parents' traumas, like concentration camps and ghettos, their homes catalyzed the transmission of these traumas.
eBook
Analysis of Technology Acceptance Model (TAM) for Financial Literacy on Kids Application Technology
Financial literacy was very important to be introduced since the early children. In Malaysia, the children began to start for formal education of the stage in preschool. This paper will discuss about the acceptance of technology as a method to teach that kids for financial literacy. With the development in technology at present, using of teaching based on technology was very important for all levels including children at preschool age. The Technology Acceptance Model (TAM) was widely used in studies related to the use of technology applications in society. There are two factors variables that will test on this paper. The first one was perceived useful and the second one was easy to use. Quantitative method will be used to collect all of data. The questionnaire survey was distributed to a total of 136 respondents which it’s have been use the financial literacy application incorporated as a tools to teach the kids. Findings of the study indicate the importance of technology as a medium to teach kids regarding the financial literacy.
Journal Article
The Wimpy Kid movie diary : the next chapter
\"Hit the road with author and illustrator Jeff Kinney and get a behind-the-scenes look at the making of the latest 20th Century Fox movie, Diary of a Wimpy Kid: The Long Haul. Find out what it takes to film a flock of seagulls invading a minivan. Learn about a robot pig and an animatronic three-year-old. And discover everything that goes into making a feature film\"--Amazon.com.
Book
S42 Diagnosing asthma in children – how can it be improved?
IntroductionNational Institute for Health and Care Excellence (NICE) guideline (NG80) aims to aid asthma diagnosis in children and suggests sequential lung function testing. We compared diagnostic outcomes using NG80 to that of an ‘expert panel’ of respiratory consultants within the Rapid Access Diagnostics for Asthma (RADicA) study.MethodThe RADicA study recruited children aged 5–16 years with symptoms suggestive of asthma. Clinical history, physical examination, and lung function [fractional exhaled nitric oxide (FeNO), spirometry, bronchodilator reversibility, peak expiratory flow variability, methacholine challenge] were assessed before and after inhaled corticosteroid treatment. The ‘expert panel’ reviewed results from all visits and assigned diagnostic categories of ‘asthma’, ‘not asthma’, ‘possible asthma’, or ‘insufficient evidence’.The NG80 algorithm was used to categorise participants into the same categories using results from the first study visit. If a child was unable to perform a test they were classed as insufficient evidence and stopped from progressing through the NG80 algorithm at that point. This process was then repeated allowing children a second attempt at spirometry and FeNO from study visit 2. Children in whom a diagnosis of ‘asthma’ was not confirmed, were reassessed with their methacholine challenge results. A positive challenge (PD20 < 0.2 mg) was used to confirm ‘asthma’; negative challenge resulted in no change in category and if no challenge was performed classed as ‘Insufficient evidence’.Results127 children [mean age (SD) 9 (3) yrs] were enrolled into the study and completed visit 1; 112 children attended visit 2. Diagnostic categories are shown for each method in the table 1 below.Expert panel gave 56% of children a diagnosis of ‘asthma’ and 20% ‘not asthma’. Allowing children, a second attempt at spirometry and FeNO increased the number with confirmed ‘asthma’ and reduced those classed as insufficient evidence, compared with one attempt. A methacholine challenge in those without a confirmed asthma diagnosis following NG80 recommended testing, significantly increased the number of children with a diagnosis of asthma.Abstract S42 Table 1Shows the number of children categorised as asthma, not asthma, possible asthma or insufficient evidence by expert panel, NG80 and its modified versions Expert Panel NG80 first attempt NG80 allowing 2 attempts at FeNO and Spirometry NG80 with Methacholine challenge Asthma 71 (56%) 20 (16%) 24 (19%) 56 (44%) Not asthma 25 (20%) 38 (30%) 42 (33%) 28 (22%) Possible asthma 4 (3%) 16 (12%) 21 (17%) 3 (2%) Insufficient evidence 27 (21%) 53 (42%) 40 (31%) 40 (31%) ConclusionRepeating simple tests in primary care may improve diagnosis and reduce the number requiring further referral. Methacholine challenge further improved the number with confirmed ‘asthma’.Please refer to page A283 for declarations of interest related to this abstract.
Journal Article