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Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine
In an effort to establish reliable thermodynamic data for proteinogenic amino acids, heat capacities for l-histidine (CAS RN: 71-00-1), l-phenylalanine (CAS RN: 63-91-2), l-proline (CAS RN: 147-85-3), l-tryptophan (CAS RN: 73-22-3), and l-tyrosine (CAS RN: 60-18-4) were measured over a wide temperature range. Prior to heat capacity measurements, thermogravimetric analysis was performed to determine the decomposition temperatures while X-ray powder diffraction (XRPD) and heat-flux differential scanning calorimetry (DSC) were used to identify the initial crystal structures and their possible transformations. Crystal heat capacities of all five amino acids were measured by Tian–Calvet calorimetry in the temperature interval from 262 to 358 K and by power compensation DSC in the temperature interval from 307 to 437 K. Experimental values determined in this work were then combined with the literature data obtained by adiabatic calorimetry. Low temperature heat capacities of l-histidine, for which no literature data were available, were determined in this work using the relaxation (heat pulse) calorimetry from 2 K. As a result, isobaric crystal heat capacities and standard thermodynamic functions up to 430 K for all five crystalline amino acids were developed.
Journal Article
Doctor Esperanto and the language of hope
\"Life was harsh in the town of Bialystok, particularly for a Jewish boy like Leyzer Zamenhof. But Leyzer thought he knew the reason for the anger and distrust. With every group speaking a different language, how could people understand each other? Without understanding, how could there be peace? Zamenhof had an idea: a \"universal\" second language everyone could speak. But a language that would be easy to learn was not easy to invent, especially when even his own father stood between him and his dream. Yet when at last in 1887 \"Doctor Esperanto\" sent his words into the world, a boy's idea became a community that spread across the globe.\"--Book jacket.
Book
On the Asymptotics to all Orders of the Riemann Zeta Function and of a Two-Parameter Generalization of the Riemann Zeta Function
We present several formulae for the large
eBook
Dose-response of common lambsquarters, redroot pigweed, and foxtail species to pyroxasulfone plus encapsulated saflufenacil applied preemergence to corn
In September 2024, BASF Canada introduced a new premixture of pyroxasulfone and encapsulated saflufenacil to control weeds in corn production. Limited research has been conducted to determine the biologically effective dose of this new premixture for the control of common lambsquarters, redroot pigweed, and green foxtail. A total of six field experiments were conducted over 2 yr (2022 and 2023) at three locations in southwestern Ontario to determine the ED 50 of pyroxasulfone + encapsulated saflufenacil needed to control these three weed species. Assessment of visible weed control 8 wk after emergence determined the ED 50 for redroot pigweed, common lambsquarters, and green foxtail control to be 170, 219, and 240 g ai ha −1 , respectively. The results of this study conclude that a higher dose of pyroxasulfone + encapsulated saflufenacil is necessary for agronomically acceptable control (>80%) of these three weed species than the proposed rate (146 to 245 g ai ha −1 ) listed on the product label.
Journal Article
The road to Wicked : the marketing and consumption of Oz from L. Frank Baum to Broadway
\"The Road to Wicked examines the long life of the Oz myth. It is both a study in cultural sustainability-- the capacity of artists, narratives, art forms, and genres to remain viable over time--and an examination of the marketing machinery and consumption patterns that make such sustainability possible. Drawing on the fields of macromarketing, consumer behavior, literary and cultural studies, and theories of adaption and remediation, the authors examine key adaptations and extensions of Baum's 1900 novel. These include the original Oz craze, the MGM film and its television afterlife, Wicked and its extensions, and Oz the Great and Powerful--Disney's recent (and highly lucrative) venture that builds on the considerable success of Wicked. At the end of the book, the authors offer a foundational framework for a new theory of cultural sustainability and propose a set of explanatory conditions under which any artistic experience might achieve it.\"-- Provided by publisher.
BOOK
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non‐alcoholic fatty liver disease
The prevalence of non‐alcoholic fatty liver disease (NAFLD) continues to increase dramatically, and there is no approved medication for its treatment. Recently, we predicted the underlying molecular mechanisms involved in the progression of NAFLD using network analysis and identified metabolic cofactors that might be beneficial as supplements to decrease human liver fat. Here, we first assessed the tolerability of the combined metabolic cofactors including
l
‐serine,
N
‐acetyl‐
l
‐cysteine (NAC), nicotinamide riboside (NR), and
l
‐carnitine by performing a 7‐day rat toxicology study. Second, we performed a human calibration study by supplementing combined metabolic cofactors and a control study to study the kinetics of these metabolites in the plasma of healthy subjects with and without supplementation. We measured clinical parameters and observed no immediate side effects. Next, we generated plasma metabolomics and inflammatory protein markers data to reveal the acute changes associated with the supplementation of the metabolic cofactors. We also integrated metabolomics data using personalized genome‐scale metabolic modeling and observed that such supplementation significantly affects the global human lipid, amino acid, and antioxidant metabolism. Finally, we predicted blood concentrations of these compounds during daily long‐term supplementation by generating an ordinary differential equation model and liver concentrations of serine by generating a pharmacokinetic model and finally adjusted the doses of individual metabolic cofactors for future human clinical trials.
Synopsis
An animal toxicity study identifies changes in human plasma metabolome and inflammatory protein markers associated with the supplementation of metabolic cofactors. Global metabolic changes are identified by integrating this data using genome‐scale metabolic modelling.
None of the administered doses of metabolic cofactors caused any detectable hematological, plasma chemistry or tissue effects in animals.
The acute changes associated with the supplementation are analysed by plasma profiling in humans.
Metabolic cofactor supplementation significantly affects the global human lipid, amino acid and anti‐oxidant metabolism.
The doses of the individual metabolic cofactors are adjusted for future human clinical trials.
Graphical Abstract
An animal toxicity study identifies changes in human plasma metabolome and inflammatory protein markers associated with the supplementation of metabolic cofactors. Global metabolic changes are identified by integrating this data using genome‐scale metabolic modelling.
Journal Article