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The Marvel cinematic universe : an official timeline
The Marvel Cinematic Universe (MCU) is vast, incredibly varied, and richly complex. Different worlds, different timelines, countless characters. This is the guide to that universe. Created in close collaboration with Marvel Studios, it will frame the MCU's biggest events: what happened, when, where, and why. Follow the entire story of the MCU from before the Big Bang to the Blip and beyond. Along the way, learn more about the evolution of the Iron Man armors, the hunt for the Infinity Stones, and the formation of The Multiverse.
Book
Analysis and Design of Three-Phase LLC Resonant Converter with Matrix Transformers
This study presents the topology of a three-phase LLC resonant converter with matrix transformers. The three-phase LLC resonant converter has the advantages of conventional LLC resonant converters, including zero-voltage switching at the primary side, zero-current switching at the secondary side, high-frequency feasibility, and high efficiency. Moreover, it has additional advantages that differ from conventional LLC, including low output capacitor current ripple, natural current sharing in three resonant currents, and a high power level. As a result of the above mentioned characteristics, LLC topology has been used in many electric vehicle charging systems, server power systems, and other high-power applications. However, as the power level becomes higher and higher, the input voltage is usually too high to reduce conduction loss, and the output current also increases. This situation makes transformer design more difficult. The increasing current means more core and copper loss, and the heat dissipation of the transformer becomes more difficult. Matrix transformer technology can improve this problem directly and simply. By utilizing matrix transformers, which are primary series connected and secondary parallel connected, the primary voltage stress and secondary current stress of the transformers can be reduced, and the output current can be distributed. The analysis of the proposed converter in this study includes a circuit operation introduction, a time-domain analysis, calculation of the transfer ratio curve in the frequency domain, and a loss analysis. The theoretical analysis and performance of the proposed converter are verified. A three-phase LLC resonant converter with matrix transformers prototype is built with a high input voltage of 800-VDC and high output current of 200-A. The output voltage is 100-VDC. The waveform and efficiency data will be shown in the experimental results.
Journal Article
Bernard Madoff and his accomplices : anatomy of a con
\"This is the first detailed study of how Bernard L. Madoff and his accomplices perpetrated a Ponzi scheme of epic proportions--what has been referred to as the \"con of the century.\" Presents the first study of Bernard L. Madoff Investment Securities, the organization where the fraud began, was centered, and flourished by duping investors for at least a decade. Documents how investors who depend on and trust investment professionals can lose money, especially given that some investment companies do not always act in their clients' best interests and that Wall Street regulators are often ineffective. Takes readers backstage to see the intricate details of the \"theatre production\" of a con game--the playacting, performances, pretending, utilization of props, and false representations that are required to achieve a \"standing ovation\" (i.e., the total fleecing of the marks)\"-- Provided by publisher.
Book
Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia
The kidney has an extraordinary ability to maintain stable fractional solute and fluid reabsorption over a wide range of glomerular filtration rates (GFRs). Internalization of filtered low molecular weight proteins, vitamins, hormones, and other small molecules is mediated by the proximal tubule (PT) multiligand receptors megalin and cubilin. Changes in GFR and the accompanying fluid shear stress (FSS) modulate acute changes in PT ion transport thought to be mediated by microvillar bending. We found that FSS also affects apical endocytosis in PT cells. Exposure of immortalized PT cell lines to physiologically relevant levels of FSS led to dramatically increased internalization of the megalin–cubilin ligand albumin as well as the fluid phase marker dextran. FSS-stimulated apical endocytosis was initiated between 15 and 30 min postinduction of FSS, occurred via a clathrin- and dynamin-dependent pathway, and was rapidly reversed upon removing the FSS. Exposure to FSS also caused a rapid elevation in intracellular Ca ²⁺ [Ca ²⁺] ᵢ, which was not observed in deciliated cells, upon treatment with BAPTA-AM, or upon inclusion of apyrase in the perfusion medium. Strikingly, deciliation, BAPTA-AM, and apyrase also blocked the flow-dependent increase in endocytosis. Moreover, addition of ATP bypassed the need for FSS in enhancing endocytic capacity. Our studies suggest that increased [Ca ²⁺] ᵢ and purinergic signaling in response to FSS-dependent ciliary bending triggers a rapid and reversible increase in apical endocytosis that contributes to the efficient retrieval of filtered proteins in the PT.
Journal Article
Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects
Selaginella doederleinii Hieron has been traditionally used as a folk antitumor herbal medicine in China. In this paper, the phytochemical components of the total biflavonoids extract from S. doederleinii were studied by using high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF MS/MS) in negative ion mode, and their in vitro and in vivo anticancer effects were evaluated. Four types of biflavonoids from S. doederleinii, including IC3′–IIC8′′, IC3′–IIC6′′, IC3′–IIC3′′′, and C–O linked biflavonoids were examined originally using QTOF MS/MS. The fragmentation behavior of IC3′–IIC3′′′ linked biflavonoids was reported for the first time. A total of twenty biflavonoids were identified or tentatively characterized and eight biflavonoids were found from S. doederleinii for the first time. Furthermore, the 3-(4,5-Dimethyl-2-thizolyl)-2,5-diphenyltertazolium bromide (MTT) assay and xenograft model of mouse lewis lung cancer(LLC) in male C57BL/6 mice revealed favorable anticancer properties of the total biflavonoids extracts from S. doederleinii. The results of this work could provide useful knowledge for the identification of biflavonoids in herbal samples and further insights into the chemopreventive function of this plant.
Journal Article
LLC Resonant Converters as Isolated Power Factor Corrector Pre-Regulators—Analysis and Performance Evaluation
The power supply of many applications running off the power line is made up of an isolated dc-dc converter powered by a front-end power factor corrector (PFC) stage. The PFC stage ensures compliance with the electromagnetic compatibility regulations but does not usually provide safety isolation since it is typically implemented with a boost converter. Lately, the increase in multi-output power supplies, especially in lighting and USB Power Delivery applications, has raised the need for an isolated PFC at power levels where currently there is not an industry standard solution. This isolated PFC is intended to power one or more non-isolated post-regulators to enable a substantial simplification of the overall architecture and a cost reduction. The usage of an LLC resonant converter as an isolated PFC has been considered and demonstrated only quite recently, raising the industry’s attention due to the favorable converter’s characteristics that have led to its success as a dc-dc converter. This paper provides two significant contributions. Firstly, it provides a quantitative assessment of the difference in the results obtained by designing an LLC-based PFC converter based on the first harmonic approximation analysis or the time-domain analysis by applying them to the design of the same converter. Secondly, it demonstrates that designing an LLC-based PFC converter to work also in the above-resonance region optimizes its performance by reducing the (magnetizing) reactive current in the resonant tank and, therefore, the rms currents on both the input and the output side and the related power loss.
Journal Article
Real Time Hardware-in-Loop Implementation of LLC Resonant Converter at Worst Operating Point Based on Time Domain Analysis
The inductor inductor capacitor (LLC) resonant topology has become more popular for deployment in high power density and high-efficiency power converter applications due to its ability to maintain zero voltage switching (ZVS) over a wider input voltage range. Due to their ease of operation and acceptable accuracy, frequency domain-related analytical methods using fundamental harmonic approximation (FHA) have been frequently utilized for resonant converters. However, when the switching frequency is far from the resonant frequency, the circuit currents contain a large number of harmonics, which cannot be ignored. Therefore, the FHA is incapable of guiding the design when the LLC converter is used to operate in a wide input voltage range applications due to its inaccuracy. As a result, a precise LLC converter model is needed. Time domain analysis is a precise analytical approach for obtaining converter attributes, which supports in the optimal sizing of LLC converters. This work strives to give a precise and an approximation-free time domain analysis for the exact modeling of high-frequency resonant converters. A complete mathematical analysis for an LLC resonant converter operating in discontinuous conduction mode (DCM)—i.e., the boost mode of operation below resonance—is presented in this paper. The proposed technique can confirm that the converter operates in PO mode throughout its working range; in addition, for primary MOSFET switches, it guarantees the ZVS and zero current switching (ZCS) for the secondary rectifier. As a function of frequency, load, and other circuit parameters, closed-form solutions are developed for the converter’s tank root mean square (RMS) current, peak stress, tank capacitor voltage, voltage gain, and zero voltage switching angle. Finally, an 8 KW LLC resonant converter is built in the hardware-in-loop (HIL) testing method on RT-LAB OP-5700 to endorse the theoretical study.
Journal Article
A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction
To mitigate risks in central nervous system (CNS) drug development, we established a high-throughput in vitro blood-brain barrier (BBB) model using LLC-PK1-MOCK and LLC-PK1-MDR1 cells in a Transwell system, aiming to replicate in vivo brain distribution and elucidate permeability mechanisms. Model integrity was assessed via transepithelial electrical resistance (TEER) and efflux functionality using control drugs (atenolol, digoxin). Bidirectional transport studies of 41 compounds quantified permeability (P
), efflux ratios (ER), and recoveries, while in vivo brain distribution parameters (K
) were derived from literature and rat studies. The model demonstrated critical BBB features: tight junction integrity (TEER > 70 Ω·cm
),
-gp efflux activity (digoxin ER = 5.10 ~ 17.12), and discrimination of passive diffusion (63.41% of drugs) from transporter-mediated mechanisms (19.5%
-gp substrates). A training set of 20 randomly selected drugs revealed a robust correlation between MDR1-derived P
and K
(R = 0.8886), with the remaining 21 compounds validating predictive accuracy (≤2-fold error). Four alkaloids exhibiting low recovery (<80%) due to lysosomal trapping were corrected using Bafilomycin A1, aligning their permeability with in vivo outcomes. These results position the LLC-PK1-MOCK/MDR1 model as a reliable surrogate tool for early CNS drug screening, enabling rapid prioritization of candidates based on BBB penetration potential. Its integration into preclinical workflows promises to accelerate the development of therapeutics for neurological disorders.
Journal Article
High-density three-dimensional localization microscopy across large volumes
Lattice light-sheet and PAINT microscopy are combined to achieve low-background detection of dense molecular labels, yielding super-resolution localization microscopy images of intricate 3D structures within dividing cells and embryos.
Extending three-dimensional (3D) single-molecule localization microscopy away from the coverslip and into thicker specimens will greatly broaden its biological utility. However, because of the limitations of both conventional imaging modalities and conventional labeling techniques, it is a challenge to localize molecules in three dimensions with high precision in such samples while simultaneously achieving the labeling densities required for high resolution of densely crowded structures. Here we combined lattice light-sheet microscopy with newly developed, freely diffusing, cell-permeable chemical probes with targeted affinity for DNA, intracellular membranes or the plasma membrane. We used this combination to perform high–localization precision, ultrahigh–labeling density, multicolor localization microscopy in samples up to 20 μm thick, including dividing cells and the neuromast organ of a zebrafish embryo. We also demonstrate super-resolution correlative imaging with protein-specific photoactivable fluorophores, providing a mutually compatible, single-platform alternative to correlative light-electron microscopy over large volumes.
Journal Article
Design and Demonstration of a 540 V/28 V SiC-Based Resonant DC–DC Converter for Auxiliary Power Supply in More Electric Aircraft
Efficient and robust power electronic converters are vital to the success of the electrification of aircraft. Especially, low voltage auxiliary converters, which usually supply high current and low voltage loads, are not readily available industrially and need special attention. In terms of energy density and efficiency, LLC converters are among the most commonly used and efficient topologies for automotive and aerospace applications. In the case of aerospace applications, a fault-tolerant topology is highly desirable to reduce the need for redundant components and weight by removing backup systems. To solve this issue, this study introduces a new 2.0 kW LLC-based converter with a reconfigurable fault-tolerant architecture. With the help of a specially designed secondary side, the proposed converter can reconfigure itself so that even if one of the semiconductor switches fails permanently, the converter can still maintain power at nominal voltage levels, ensuring that the aircraft’s vital functionality is preserved. This paper also describes the basic operation principle, component-design aspects, conduction loss reduction techniques, and control system algorithm. Finally, a 2.0 kW experimental prototype is built to verify and demonstrate the operation of the proposed reconfigurable LLC converter.
Journal Article