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Leprosy and colonialism : Suriname under Dutch rule, 1750-1950
Leprosy and colonialism investigates the history of leprosy in Suriname within the context of Dutch colonial power and racial conflict, from the plantation economy and the age of slavery to its legacy in the modern colonial state. It explores the relationship between the modern stigmatization and exclusion of people affected with leprosy, and the political tensions and racial fears originating in colonial slave society, exerting their influence until after the decolonization up to the present day. In the book colonial sources are read from shifting perspectives, of the colonial rulers and, 'from below', the ruled. Though leprosy is today a neglected tropical disease, recognizing influences of our colonial heritage in our global management of health and disease, and exploring the perspectives of other cultures are essential in a time in which migration movements make the permeability of boundaries, and transmission of diseases, more common then perhaps ever before.-- Source other than Liibary of congress.
Book
No ordinary day
Valli has always been afraid of the lepers living on the other side of the train tracks in the coal town of Jharia, India, so when a chance encounter with a doctor reveals she also has leprosy, Valli rejects help and begins an uncertain life on the streets.
Book
The cellular architecture of the antimicrobial response network in human leprosy granulomas
Granulomas are complex cellular structures composed predominantly of macrophages and lymphocytes that function to contain and kill invading pathogens. Here, we investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spatial sequencing to leprosy biopsy specimens. We focused on reversal reactions (RRs), a dynamic process whereby some patients with disseminated lepromatous leprosy (L-lep) transition toward self-limiting tuberculoid leprosy (T-lep), mounting effective antimicrobial responses. We identified a set of genes encoding proteins involved in antimicrobial responses that are differentially expressed in RR versus L-lep lesions and regulated by interferon-γ and interleukin-1β. By integrating the spatial coordinates of the key cell types and antimicrobial gene expression in RR and T-lep lesions, we constructed a map revealing the organized architecture of granulomas depicting compositional and functional layers by which macrophages, T cells, keratinocytes and fibroblasts can each contribute to the antimicrobial response.
Modlin and colleagues examined the skin lesions of human leprosy patients using single-cell RNA sequencing coupled to cellular spatial mapping. Their analysis maps the architecture of granulomas in leprosy lesions from patients with leprosy with localized disease (tuberculoid leprosy, reversal reaction) to those with progressive infection (lepromatous leprosy).
Journal Article