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Dear Editor, N6-methyladenosine （m6A）, as the most abundant internal modification with ubiquitous feature in eukaryotic mRNAs, has been connected with many fundamental aspects of RNA metabolism such as translation [1-3], splicing [4, 5], stability and decay [6]. m6A modification is reversible and can be regulated by three groups of molecules commonly referred to as writers, erasers and readers, m6A writers are the components of the multi-complex methyltransferase catalyzing the formation of m6A methylation, among which METTL3,