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To observe the changes of Nogo/NgR and Rho/ROCK signaling pathway-related gene and protein expression in rats with spinal cord injury (SCI) treated with electroacupuncture (EA) and to further investigate the possible mechanism of EA for treating SCI. Allen's method was used to create the SCI rat model. Sixty-four model rats were further subdivided into four subgroups, namely, the SCI model group (SCI), EA treatment group (EA), blocking agent Y27632 treatment group (Y27632) and EA+blocking agent Y27632 treatment group (EA+Y), according to the treatment received. The rats were subjected to EA and/or blocking agent Y27632 treatment. After 14 days, injured spinal cord tissue was extracted for analysis. The mRNA and protein expression levels were determined by real-time fluorescence quantitative PCR and Western blotting, respectively. Cell apoptosis changes in the spinal cord were evaluated by in situ hybridization. Hindlimb motor function in the rats was evaluated by Basso-Beattie-Bresnahan assessment methods. Except for RhoA protein expression, compared with the SCI model group, EA, blocking agent Y27632 and EA+blocking agent Y27632 treatment groups had significantly reduced mRNA and protein expression of Nogo-A, NgR, LINGO-1, RhoA and ROCK II in spinal cord tissues, increased mRNA and protein expression of MLCP, decreased p-MYPT1 protein expression and p-MYPT1/MYPT1 ratio, and caspase3 expression, and improved lower limb movement function after treatment for 14 days (P<0.01 or <0.05). The combination of EA and the blocking agent Y27632 was superior to EA or blocking agent Y27632 treatment alone (P < 0.01 or <0.05). EA may have an obvious inhibitory effect on the Nogo/NgR and Rho/ROCK signaling pathway after SCI, thereby reducing the inhibition of axonal growth, which may be a key mechanism of EA treatment for SCI.

Background: Apoptosis and autophagy are two important patterns of cell death in the process of heart failure. Qi-Li-Qiang-Xin (QLQX), a traditional Chinese medicine, has been frequently used in the treatment of chronic heart failure (CHF) in China. However, the potential effect of QLQX on autophagy has not been reported. In this study, we aimed to investigate whether QLQX alleviated isoproterenol (ISO)-induced myocardial injury through regulating autophagy.Methods: The rapid identification of chemical ingredients of QLQX was performed by UPLC-Q-TOF-MS, and the contents of major constituents in QLQX were also measured by UPLC-Q-TOF-MS. ISO was used to induce myocardial injury in H9c2 cardiomyocytes and SD rats. In vivo , cardiac function was evaluated by echocardiography and cardiac structure was observed by HE and Masson staining. Expressions of Bcl-2, Bax, LC3, P62, AKT, p-AKT, mTOR, and p-mTOR were detected by western blotting. In vitro , H9c2 cells were pretreated with QLQX for 3 h before ISO (80 µM, 48h) addressed. Cell viability, LDH and CK-MB release, apoptosis ratio, and the level of autophagy were measured. Western blotting was also performed to detected related protein expressions.Result: In vivo , treatment by QLQX significantly improved cardiac function and alleviated ISO-induced myocardial structural damage. In addition, QLQX markedly decreased apoptosis and inhibited autophagic activity, accompanied by activating the AKT/mTOR pathway. In vitro , the increased cell apoptosis induced by ISO was paralleling with the gradually increasing level of autophagy. Furthermore, 3-MA, an autophagic inhibitor, could block ISO-induced autophagy in H9c2 cells. Our results suggested that both QLQX and 3-MA treatment could decrease cell death induced by ISO, implying that QLQX protected against ISO-induced myocardial injury possibly by inhibiting excessive autophagy-mediated cell death. In addition, blockage of AKT signaling by an AKT inhibitor, capivasertib, could reduce the effect of QLQX on inhibiting ISO-induced apoptosis and autophagy-mediated cell death.Conclusion: QLQX could alleviate ISO-induced myocardial injury by inhibiting apoptosis and excessive autophagy-mediated cell death via activating the AKT/mTOR pathway.

Against the backdrop of urban–rural integration development in China, the government has further strengthened its support for rural migrant workers’ urban employment and entrepreneurship, as well as their urbanization. Nevertheless, influenced by the current urban–rural development environment and public policies, a portion of rural migrant workers have evolved into two distinct groups: those with clear intentions to settle in cities or return to their hometowns and those trapped in a “neither-nor” situation, who are unable to fully integrate into urban life or seamlessly return to the countryside. This study, based on field investigations conducted in 21 cities across seven major geographical regions in China, reveals a ternary differentiation in migration intentions among rural migrant workers: “Retain in the cities”, “Return flow”, and “Blind direction”. In advancing the urban–rural integration strategy, the “clearly-oriented” groups, choosing to stay or return, can serve as dynamic forces in reconciling resources between urban and rural areas, thereby fostering closer urban–rural ties. Conversely, the “aimless wandering” group, characterized by stagnation, confusion, frequent mobility, and recurrent unemployment, poses numerous negative impacts on urban–rural interaction and coordination, hindering the in-depth integration of urban and rural areas to some extent. Drawing upon the internationally recognized Push-Pull Theory and Social Integration Theory within the field of population migration, this study conducts an empirical analysis of large-scale sample data to explore the characteristic factors and formation mechanisms underlying the “staying”, “returning”, and “blind direction” intentions, with a particular focus on the internal dynamics shaping and evolving the “aimless wandering” group. Finally, grounded in the empirical findings, this study advocates a collaborative approach between the Chinese government and various sectors of society to address the issue by promoting employment guidance, enhancing security measures, and other initiatives that encourage rural migrant workers to either stay in cities or return to their hometowns. It aims to provide policy recommendations for a definitive resolution of the rural migrant worker issue during the crucial period of urban–rural integration development.

The 20th National Congress of the Chinese Communist Party (CCP) in October 2022 secured Xi Jinping's third term as General Secretary and secured a team of supporters amid socioeconomic woes and increasingly hostile global circumstances. While leadership matters in all political systems, it matters much more in totalitarian and authoritarian ones. Political leaders in democracies are constrained by electoral cycles, term limits, and approval ratings, but the leaders of the PRC's single-party system that emphasizes discipline, hierarchy, and democratic centralism operate relatively unchecked by bureaucracy, opposition forces, or public opinion. Its leaders possess the ultimate decision-making authority in national security and strategic policies (Zhao, 2022, p. 5). The consolidation of Xi's power has far-reaching implications for China's foreign policy. As a feared, sycophantically revered, and ruthless emperor confident in his country's military power and economic clout, Xi feels equipped to accomplish his mission of making China great again. He has also inherited a pervasive insecurity of pushback from Western powers that threatens his authoritarian rule. He has therefore upheld the security of the regime beyond Deng Xiaoping and his decades of prioritizing growth. Proactively stifling any opposition to his rule and cracking down on any hint of a ＂color revolution＂ at home in connection with foreign forces, Xi has strengthened the military and reorganized the economy in preparation for a possible showdown with the United States. He has required Chinese diplomats to act as ＂wolf warriors＂ in diplomatic battles and fight criticisms of the regime even at the cost of escalating international tensions. While his team of supporters has maximized his power to implement his policies, this has also prevented his colleagues from counseling against any mistakes they may anticipate or discover. Intentionally or not, he has minimized opportunities to correct his mistakes and increased the stakes and the risks they present, raising the potential for his country to become embroiled in a foreign adventure of no return.

A rebound in China-ROK diplomacy raised optimism after a slow start to 2024, paving the way for the summit between Xi Jinping and Yoon Suk Yeol on Nov. 15. They met on the sidelines of APEC Peru before attending the G20 summit in Brazil. Foreign Ministers Wang Yi and Cho Tae-yul met in Beijing on May 13, facilitating the China-ROK-Japan trilateral summit and Yoon's meeting with Premier Li Qiang in Seoul. As China-DPRK exchanges dwindled compared to the first third of this year, Xi Jinping and Kim Jong Un's summits with Putin in May and June raised questions about the direction of China's Korea policy. Donald Trump's reelection in November intensified debate on the regional security and economic implications of US-China competition.

Background Qi Li Qiang Xin (QLQX) capsule has a solid theoretical basis and clinical efficacy in the treatment of chronic heart failure; however, the underlying mechanisms remain obscure. This study was designed to determine the effect of the QLQX on the treatment of heart failure and delineate the underlying mechanisms via a nontargeted metabolomics and lipidomics approach. Methods A rat model of heart failure after myocardial infarction (MI) was established via permanent ligation of the anterior descending branch of the left coronary artery. The rats were then randomly divided into the SHAM group, the MI group, the QLQX group (1.3 g/kg/day), and the VAL (valsartan) group (80 mg/kg/day). Cardiac function was measured via echocardiography. The levels of serum NT-proBNP and hs-cTn-I were detected via ELISA. H&E staining and Masson’s trichrome staining were used to observe cardiac morphology and myocardial fibrosis. Using the UPLC-QTOF/MS method, metabolomics and lipidomics analyses were performed on the plasma of the rats in each group to identify biomarkers and potential amino acid and lipid therapy mechanisms for heart failure after QLQX administration in rats with heart failure. Results QLQX capsule improved the heart f unction of rats with heart failure after myocardial infarction by increasing the LVEF and LVFS, decreasing the LVIDd and LVIDs. QLQX capsule reduce the levels of NT-proBNP and hs-cTn-I, which are markers of heart failure, and improve the myocardial infarction area and degree of myocardial fibrosis. In addition, in the metabolomics analysis, a total of 17 plasma metabolites were significantly different between heart failure rats and normal rats, all of which recovered significantly after QLQX treatment. These metabolites mainly participate in the biosynthesis of unsaturated fatty acids; valine, leucine and isoleucine biosynthesis; phenylalanine, tyrosine and tryptophan biosynthesis; and glycerophospholipid metabolism. Lipid analysis revealed that FA18:2, FA18:3, FA20:5, and FA22:6 in the QLQX group were significantly altered ( P  < 0.01). The peak area contents of FA18:2, FA18:3, FA20:5, and FA22:6 in the sham surgery group and model group also significantly decreased ( P  < 0.05). Conclusion This study elucidates the therapeutic effect of QLQX on heart failure rats and elucidates its potential mechanisms, which are related mainly to the regulation of amino acid and lipid metabolism in heart failure rats through metabolomics and lipidomics experiments.