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The purpose of the present study was to evaluate the association between lithium levels in the public water supply and prefecture-based suicide rates in Greece. Analyses were conducted with respect to lithium levels in 149 samples from 34 prefectures of Greece. The average lithium level was 11.10 μg/l (range 0.1 to 121 μg/l). The results indicate that there is a tendency for lower suicide rates in the prefectures with high levels of lithium in drinking water. Ecological studies explained by researchers Schrauzer and Shrestha have revealed the existence of statistically significant inverse associations between the lithium levels in drinking water and the incidence of suicides, homicides, rapes, possession of narcotic drugs, and in juveniles, the rates of runaway from home. Such a result of inverse relationship was not proven by Kabacs et al., most likely because the differences of the lithium levels in the selection of their case–control samples were not large enough. In addition, probably the selection of random regions in Japan and East England might have been biased. Thus, the addition of small amounts of lithium to the drinking water could provide an effective means to lower the incidence of these conditions in the general population. Furthermore, the nutritional importance of lithium in the form of the carbonate named lithium carbonate (Li₂CO₃) is currently still viewed primarily as a pharmacological agent. The study by Al-Chalabi et al. state that the therapeutic activity of lithium in amyotrophic lateral sclerosis (ALS) is worth investigating. Any drug that can be shown to slow the course of ALS in a clinically significant way and to be safe and well tolerated will be an important advance for patients with this disease.

The evolution of the global carbon and silicon cycles is thought to have contributed to the long-term stability of Earth’s climate 1 – 3 . Many questions remain, however, regarding the feedback mechanisms at play, and there are limited quantitative constraints on the sources and sinks of these elements in Earth’s surface environments 4 – 12 . Here we argue that the lithium-isotope record can be used to track the processes controlling the long-term carbon and silicon cycles. By analysing more than 600 shallow-water marine carbonate samples from more than 100 stratigraphic units, we construct a new carbonate-based lithium-isotope record spanning the past 3 billion years. The data suggest an increase in the carbonate lithium-isotope values over time, which we propose was driven by long-term changes in the lithium-isotopic conditions of sea water, rather than by changes in the sedimentary alterations of older samples. Using a mass-balance modelling approach, we propose that the observed trend in lithium-isotope values reflects a transition from Precambrian carbon and silicon cycles to those characteristic of the modern. We speculate that this transition was linked to a gradual shift to a biologically controlled marine silicon cycle and the evolutionary radiation of land plants 13 , 14 . Analysis of shallow-water marine carbonate samples from 101 stratigraphic units allows construction of a record of lithium isotopes from the past 3 billion years, tracking the evolution of the global carbon and silicon cycles.

The prevalence of mental health conditions and national suicide rates are increasing in many countries. Lithium is widely and effectively used in pharmacological doses for the treatment and prevention of manic/depressive episodes, stabilising mood and reducing the risk of suicide. Since the 1990s, several ecological studies have tested the hypothesis that trace doses of naturally occurring lithium in drinking water may have a protective effect against suicide in the general population. To synthesise the global evidence on the association between lithium levels in drinking water and suicide mortality rates. The MEDLINE, Embase, Web of Science and PsycINFO databases were searched to identify eligible ecological studies published between 1 January 1946 and 10 September 2018. Standardised regression coefficients for total (i.e. both genders combined), male and female suicide mortality rates were extracted and pooled using random-effects meta-analysis. The study was registered with PROSPERO (CRD42016041375). The literature search identified 415 articles; of these, 15 ecological studies were included in the synthesis. The random-effects meta-analysis showed a consistent protective (or inverse) association between lithium levels/concentration in publicly available drinking water and total (pooled β = -0.27, 95% CI -0.47 to -0.08; P = 0.006, I2 = 83.3%), male (pooled β = -0.26, 95% CI -0.56 to 0.03; P = 0.08, I2 = 91.9%) and female (pooled β = -0.13, 95% CI -0.24 to -0.02; P = 0.03, I2 = 28.5%) suicide mortality rates. A similar protective association was observed in the six studies included in the narrative synthesis, and subgroup meta-analyses based on the higher/lower suicide mortality rates and lithium levels/concentration. This synthesis of ecological studies, which are subject to the ecological fallacy/bias, supports the hypothesis that there is a protective (or inverse) association between lithium intakes from public drinking water and suicide mortality at the population level. Naturally occurring lithium in drinking water may have the potential to reduce the risk of suicide and may possibly help in mood stabilisation, particularly in populations with relatively high suicide rates and geographical areas with a greater range of lithium concentration in the drinking water. All the available evidence suggests that randomised community trials of lithium supplementation of the water supply might be a means of testing the hypothesis, particularly in communities (or settings) with demonstrated high prevalence of mental health conditions, violent criminal behaviour, chronic substance misuse and risk of suicide.

This study investigates geochemical characteristics and resource potential of water-soluble lithium in lithium-rich salt lake sediments from the Qaidam Basin, focusing on the East Taijinar Salt Lake and Bieletan area. Through X-ray diffraction (XRD), elemental analysis (ICP-OES), and laser particle size analysis (LPSA), sediment samples were analyzed to assess mineral composition, lithium distribution and its occurrence forms. Results reveal distinct vertical zonation: lithium, boron, and potassium peak in clay-rich layers, contrasting with lower concentrations in halite-dominated layers. Regional patterns indicate that lithium enrichment in sediments aligns closely with brine, centered around Yiliping and East/West Taijinar Salt Lakes. Water-soluble lithium primarily originates from weak adsorption on clay minerals, with secondary contributions from intercrystalline brine, halite fluid inclusions, and gypsum dissolution. The clay layers exhibit lithium concentrations exceeding industrial grade and favorable Mg/Li ratios, comparable to brine mining standards. Co-enrichment of boron (415 ppm) and potassium highlights multi-resource potential. These findings highlight sediments as lithium reservoirs, which can serve as a sustainable potential supplement during brine depletion and enhance resource resilience in the Qaidam Basin. This study provides critical insights into lithium migration, enrichment mechanisms, and strategic resource management in evaporitic systems.

Lithium has broad applications in several emerging industries and fields, including high energy batteries, energy storage, aerospace, and controlled nuclear reactions. Currently, the discrepancy between the supply and demand for lithium resources increases, and its distribution is uneven. Within the framework of the \"Belt and Road\" Initiative, the lithium trade pattern evolves constantly. However, the trade pattern of lithium in the nations along the \"Belt and Road\" is likely to face substantial repercussions in modern world of unilateral protectionism and geopolitical conflicts. Taking the social network analysis approach as a tool, this study first examines the characteristics of the lithium trade network structure as it has evolved over the years in the Belt and Road countries, from 2000 to 2022. Additionally, this study uses the quadratic assignment problem approach to analyze the factors influencing the evolution of the lithium trade network. The study shows that: (1) The spatial patterns of import and export trade network of lithium in countries along the route has a certain path dependence. And the market is mainly concentrated in East Asia, Central and Eastern Europe, South America and Southeast Asia. (2) The network density of the countries along the route has increased year after year, but it remains low. And the fluctuation of the network’s reciprocity has increased, with a huge magnitude of variation. The number of core countries in the network has decreased over time, but the core-periphery structure has stayed largely steady. China, Chile, and South Korea are the network’s main node countries. (3) Regarding the influencing factors, the differences in economic and technological development between these countries have a beneficial impact on the formation of lithium trade; whether or not regional trade agreements have been signed, the differences about average tax rates for mineral products, bordering countries, and similar languages and cultures are all conducive to the establishment of close trade links. The contribution of this essay is of paramount importance for understanding different countries’ role along the Belt and Road in the lithium trade network pattern, and promoting regional trade cooperation.

There is some evidence that natural levels of lithium in drinking water may have a protective effect on suicide mortality. To evaluate the association between local lithium levels in drinking water and suicide mortality at district level in Austria. A nationwide sample of 6460 lithium measurements was examined for association with suicide rates per 100,000 population and suicide standardised mortality ratios across all 99 Austrian districts. Multivariate regression models were adjusted for well-known socioeconomic factors known to influence suicide mortality in Austria (population density, per capita income, proportion of Roman Catholics, as well as the availability of mental health service providers). Sensitivity analyses and weighted least squares regression were used to challenge the robustness of the results. The overall suicide rate (R(2) = 0.15, β = -0.39, t = -4.14, P = 0.000073) as well as the suicide mortality ratio (R(2) = 0.17, β = -0.41, t = -4.38, P = 0.000030) were inversely associated with lithium levels in drinking water and remained significant after sensitivity analyses and adjustment for socioeconomic factors. In replicating and extending previous results, this study provides strong evidence that geographic regions with higher natural lithium concentrations in drinking water are associated with lower suicide mortality rates.

Background/Objectives: Higher lithium (Li) levels in drinking water have been linked to lower suicide rates in the general population in several ecological studies, though this relationship is not always consistent. The main limitation of such studies is the assumption that Li content in drinking water is directly correlated with total Li intake, which may not always be the case for several reasons. Methods: In this context, we conducted a biomonitoring study to compare urinary Li levels—assumed as a reliable indicator of total Li intake—among individuals from three regions with different suicide relative risks (RRs): Porto Metropolitan Area (PMA; low RR), Central region (CT; intermediate RR), and Trás-os-Montes region (TM; high RR). Each participant provided a urine sample (first morning) and two water samples (drinking water and environmental water). Li concentrations were determined using ICP-MS. Results: A total of 311 individuals participated in this study. The median (P25–P75) urinary Li concentration was 21.9 (15.1–46.0) in PMA, 19.0 (12.6–30.4) in CT, and 24.2 (14.6–38.7) µg/L in TM, with no statistically significant differences between regions (Kruskal–Wallis test with Bonferroni correction). Urinary Li was weakly correlated with Li in drinking water (ρ = 0.174; p = 0.002) but not with Li in environmental water (ρ = −0.036; p = 0.694). Conclusions: These findings do not support a protective role of natural Li exposure in suicide risk at the low levels found in drinking (P75 = 3.75 µg/L) and environmental (P75 = 6.87 µg/L) water. More robust and comprehensive biomonitoring studies are needed to clarify the potential impact of natural Li exposure on suicide rates.

Lithium has been the treatment of choice for patients with bipolar disorder . However, lithium overdose happens more frequently since it has a very narrow therapeutic range in blood, necessitating investigation of its adverse effects on blood cells. The possible changes that lithium exposure may have on functional and morphological characteristics of human red blood cells (RBCs) have been studied ex vivo using single-cell Raman spectroscopy, optical trapping, and membrane fluorescent probe. The Raman spectroscopy was performed with excitation at 532 nm light, which also results in simultaneous photoreduction of intracellular hemoglobin (Hb). The level of photoreduction of lithium-exposed RBCs was observed to decline with lithium concentration, indicating irreversible oxygenation of intracellular Hb from lithium exposure. The lithium exposure may also have an effect on RBC membrane, which was investigated via optical stretching in a laser trap and the results suggest lower membrane fluidity for the lithium-exposed RBCs. The membrane fluidity of RBCs was further studied using the Prodan generalized polarization method and the results verify the reduction of membrane fluidity upon lithium exposure.

Suicide is a major public health concern. High-dose lithium is used to stabilize mood and prevent suicide in patients with affective disorders. Lithium occurs naturally in drinking water worldwide in much lower doses, but with large geographical variation. Several studies conducted at an aggregate level have suggested an association between lithium in drinking water and a reduced risk of suicide; however, a causal relation is uncertain. Individual-level register-based data on the entire Danish adult population (3.7 million individuals) from 1991 to 2012 were linked with a moving five-year time-weighted average (TWA) lithium exposure level from drinking water hypothesizing an inverse relationship. The mean lithium level was 11.6 μg/L ranging from 0.6 to 30.7 μg/L. The suicide rate decreased from 29.7 per 100,000 person-years at risk in 1991 to 18.4 per 100,000 person-years in 2012. We found no significant indication of an association between increasing five-year TWA lithium exposure level and decreasing suicide rate. The comprehensiveness of using individual-level data and spatial analyses with 22 years of follow-up makes a pronounced contribution to previous findings. Our findings demonstrate that there does not seem to be a protective effect of exposure to lithium on the incidence of suicide with levels below 31 μg/L in drinking water.

This study incorporated hydrogeochemical facies, the entropy-weighted water quality index (EWQI), multivariate statistics, and probabilistic human exposure assessment to investigate hydrogeochemistry, analyze groundwater quality, and estimate potential risks to human health in a lithium-rich ore area (Jadar River basin, Serbia). The findings designated the Ca·Mg-HCO 3 hydrogeochemical type as the predominant type of groundwater, in which rock weathering and evaporation control the major ion chemistry. Due to the weathering of a lithium-rich mineral (Jadarite), the lithium content in the groundwater was very high, up to 567 mg/L, with a median value of 4.3 mg/L. According to the calculated EWQI, 86.4% of the samples belong to poor and extremely poor quality water for drinking. Geospatial mapping of the studied area uncovered several hotspots of severely contaminated groundwater. The risk assessment results show that groundwater contaminants pose significant non-carcinogenic and carcinogenic human health risks to residents, with most samples exceeding the allowable limits for the hazard index (HI) and the incremental lifetime cancer risk (ILCR). The ingestion exposure pathway has been identified as a critical contaminant route. Monte Carlo risk simulation made apparent that the likelihood of developing cancerous diseases is very high for both age groups. Sensitivity analysis highlighted ingestion rate and human body weight as the two most influential exposure factors on the variability of health risk assessment outcomes.