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Background Despite effective national immunisation programmes in Europe, some groups remain incompletely or un-vaccinated (‘under-vaccinated’), with underserved minorities and certain religious/ideological groups repeatedly being involved in outbreaks of vaccine preventable diseases (VPD). Gaining insight into factors regarding acceptance of vaccination of ‘under-vaccinated groups’ (UVGs) might give opportunities to communicate with them in a trusty and reliable manner that respects their belief system and that, maybe, increase vaccination uptake. We aimed to identify and describe UVGs in Europe and to describe beliefs, attitudes and reasons for non-vaccination in the identified UVGs. Methods We defined a UVG as a group of persons who share the same beliefs and/or live in socially close-knit communities in Europe and who have/had historically low vaccination coverage and/or experienced outbreaks of VPDs since 1950. We searched MEDLINE, EMBASE and PsycINFO databases using specific search term combinations. For the first systematic review, studies that described a group in Europe with an outbreak or low vaccination coverage for a VPD were selected and for the second systematic review, studies that described possible factors that are associated with non-vaccination in these groups were selected. Results We selected 48 articles out of 606 and 13 articles out of 406 from the first and second search, respectively. Five UVGs were identified in the literature: Orthodox Protestant communities, Anthroposophists, Roma, Irish Travellers, and Orthodox Jewish communities. The main reported factors regarding vaccination were perceived non-severity of traditional “childhood” diseases, fear of vaccine side-effects, and need for more information about for example risk of vaccination. Conclusions Within each UVG identified, there are a variety of health beliefs and objections to vaccination. In addition, similar factors are shared by several of these groups. Communication strategies regarding these similar factors such as educating people about the risks associated with being vaccinated versus not being vaccinated, addressing their concerns, and countering vaccination myths present among members of a specific UVG through a trusted source, can establish a reliable relationship with these groups and increase their vaccination uptake. Furthermore, other interventions such as improving access to health care could certainly increase vaccination uptake in Roma and Irish travellers.

Immunization has become one of the major contributors to public health globally as it prevents communicable disease, particularly in children. The objective of this study was to estimate the extent of timely immunization coverage and to investigate the determinants of incomplete and untimely vaccination. Methods: The study used data from the latest Bangladesh Demographic Health Survey (BDHS) 2014. A total sample of 1631 children aged 12–23 months who had an Expanded Program on Immunization (EPI) card and immunization history were analyzed. Multivariable logistic regression models were used to determine the significant influencing factors on untimely vaccination (BCG, pentavalent vaccine/OPV, and measles) and incomplete vaccination. The results were presented in terms of adjusted odds ratio (AOR) with a 95% confidence interval and a significance level p < 0.05. Results: The proportions of children who received timely vaccinations were 24% for BCG, 46% for pentavalent 3, and 53% for measles, whereas 76%, 51%, and 36% children failed to receive the BCG, pentavalent 3, and measles vaccines, respectively, in a timely manner. The proportion of early vaccination was 3% for pentavalent 3 and 12% for measles. Several significant influencing factors including age, maternal education and working status, awareness of community clinics, socioeconomic status, and geographic variation significantly contributed to untimely and incomplete vaccination of children in Bangladesh. Conclusions: The study identified some key determinants of untimely and incomplete childhood vaccinations in the context of Bangladesh. The findings will contribute to the improvement of age-specific vaccination and support policy makers in taking the necessary control strategies with respect to delayed and early vaccination in Bangladesh.

Evidence on the human papillomavirus (HPV) vaccine shows that it is effective in reducing the burden of HPV-related diseases. For more than 15 years the HPV vaccine has been offered free of charge in Italy to girls from the age of 12. Over time, the free offer of the HPV vaccine has also been extended to boys and to young adults at risk of developing HPV lesions. Despite the HPV vaccine’s effectiveness and availability, vaccination coverage is low in Italy, with a reported value of 46.5% in 2020. Furthermore, in the southern administrative regions, vaccination coverage is even lower than national values, with 25.9% coverage in Sicily. A cross-sectional study was conducted among university and high school students in the Palermo area (Sicily, Italy) in order to identify the determinants of HPV vaccination adherence by using a questionnaire that investigated factors of HPV vaccine practice. The study explored the behavioral attitude by using the Health Belief Model (HBM), and also used the SILS test and the METER test to investigate the level of health literacy (HL). Overall, 3,073 students were enrolled, and less than a third reported they had completed the vaccination schedule (n = 925, 30.1%). Multivariable analysis showed that the factors directly associated with the adherence to HPV vaccination were female sex (OR = 4.43, p < 0.001), high HBM total score (OR = 4.23, p < 0.001), good HL level (OR = 1.26, p = 0.047), parents (OR = 1.78, p = 0.004), general practitioner (OR = 1.88, p = 0.001), and educational material provided by public vaccination services (OR = 1.97, p = 0.001) as HPV vaccine information sources. Further health-promotion programs focused on improving HL and perception of the HPV vaccine’s benefits should be implemented in order to achieve the desirable 95% vaccination coverage.

Since 2016, there has been a decrease in vaccination coverage for the childhood schedule of the National Immunization Program (PNI) in Brazil. To identify the reasons for vaccine hesitancy, we conducted a household survey of 31,001 live-born children living in the 26 Brazilian state capitals and the Federal District in 2017 and 2018. Census tracts were stratified according to socioeconomic status, we interviewed parents and/or guardians to collect information on the mother, child, reasons for not vaccinating, and other data. To identify the determinants of vaccine hesitancy, were used the “5Cs” (confidence, complacency and convenience, communication and context). Confidence: 94.5 % of parents/guardians of children trust the vaccines; 98.4 % believe it is important to vaccinate their children, and 20,0 % believe that vaccines are associated with serious adverse events. Complacency: 96.7 % decided to vaccinate their children with all the vaccines recommended; 7.2 % experienced difficulties with vaccination (distance and opening hours of the vaccination service, lack of time, problems with the child's health) despite going to the vaccination appointment; 22.9 % did not vaccinate their children (vaccine unavailable, clinic closed, health care provider absent, fear of adverse events). Communication: 24.5 % decided not to take their child for vaccination because of the pandemic; 24.4 % feared a reaction to the vaccine, and 9.2 % did not have the vaccine recommended by their doctor or health care provider. Socioeconomic status: vaccine confidence was lower among mothers with low education levels and lower-income families. Conclusions: Operational difficulties in the health care network were the main reasons for vaccine hesitancy in Brazilian state capitals during the study period. Although the proportion of parents/guardians who do not vaccinate their children voluntarily is low, this is a problem that needs to be consider so that it does not increase over time due to the infodemic.

Maintaining high vaccination readiness is key to sustaining high vaccination coverage. In this study, we aim to estimate the vaccination readiness of the Norwegian adult population and explore its associations with sociodemographic characteristics and the intention to be vaccinated. A representative sample of the adult Norwegian population were surveyed with the validated 7C questionnaire on general vaccination readiness, which contains items about seven components of vaccination readiness (confidence, complacency, constraints, calculation, collective responsibility, compliance and conspiracy). Participants were also asked about sociodemographic background and their intention to be vaccinated against COVID-19 and influenza. We assessed associations involving vaccination readiness in linear and logistic regression models. A total of 4137 individuals participated in the survey (overall response rate 50.5 %). Our study sample was comparable to the Norwegian population in terms of sociodemographic characteristics. On a scale from 1 to 7, the mean overall 7C vaccination readiness score was 4.82. Low overall vaccination readiness was associated with sociodemographic characteristics such as male sex, younger age, low education, low income and living alone. Overall vaccination readiness was strongly associated with intention to receive a booster dose of COVID-19 vaccine among those aged 18 years or older (adjusted odds ratio (aOR) 10.23, 95 % confidence interval (95 %CI) 8.38 to 12.49)), and with influenza vaccination among those aged 65 years or older (aOR 7.38, 95 %CI 4.51 to 12.10)), as were each of the seven vaccination readiness components when regressed on vaccination intention. Overall general vaccination readiness was relatively high in the adult population in Norway. However, it differed between sociodemographic groups. Component and overall vaccination readiness scores were associated with intention to be vaccinated, and these associations were stronger for booster vaccination against COVID-19 than against influenza. The observed 7C estimates enable tracking of vaccination readiness over time and help identify themes and populations that can be targeted to improve compliance with vaccination program recommendations.

Cholera remains a persistent public health challenge, particularly in resource-limited and conflict-affected settings where inadequate water, sanitation, and hygiene infrastructure exacerbate disease transmission. Sudan has experienced recurrent cholera outbreaks, with two major waves occurring between April 2023 and November 2024, affecting 63,112 individuals and resulting in 1377 fatalities. Given the ongoing armed conflict and humanitarian crisis, traditional cholera prevention measures are often insufficient, necessitating the rapid deployment of Oral Cholera Vaccine (OCV) as a key outbreak response strategy. This study evaluates the administrative coverage, operational performance, and economic efficiency of Sudan's OCV campaigns during this period. A cross-sectional analysis was conducted on Sudan's nationwide OCV campaigns from November 2023 to November 2024. The study assessed vaccination strategies, cold chain resilience, social mobilization efforts, and operational costs per dose. A total of 8,584,190 doses were administered to a target population of 8,654,546, achieving an administrative coverage rate of 99%. Coverage varied across implementation sites. The campaign was conducted under extreme conflict conditions, requiring innovative strategies such as house-to-house vaccination, mobile teams, and integration with novel Oral Polio Vaccine (nOPV) campaigns. Vaccine wastage was minimal (<0.0001 %), and the average operational cost per dose was $0.65. Despite logistical challenges, Sudan reduced the lead time from outbreak confirmation to vaccine request submission to just three days, though vaccine arrival delays of 2–4 weeks remained a bottleneck. Sudan's experience demonstrates the feasibility and cost-effectiveness of OCV campaigns in conflict-affected and resource-limited settings. The high coverage rate, efficient vaccine utilization, and successful adaptation of vaccination strategies highlight the resilience of Sudan's health system in responding to outbreaks amid ongoing conflict and provide critical insights for future cholera control efforts in fragile settings, using partnerships, agile vaccine deployment mechanisms, and innovative implementation approaches.

It is estimated that vaccinating 50%-70% of school-aged children for influenza can produce population-wide indirect effects. We evaluated a city-wide school-located influenza vaccination (SLIV) intervention that aimed to increase influenza vaccination coverage. The intervention was implemented in ≥95 preschools and elementary schools in northern California from 2014 to 2018. Using a matched cohort design, we estimated intervention impacts on student influenza vaccination coverage, school absenteeism, and community-wide indirect effects on laboratory-confirmed influenza hospitalizations. We used a multivariate matching algorithm to identify a nearby comparison school district with pre-intervention characteristics similar to those of the intervention school district and matched schools in each district. To measure student influenza vaccination, we conducted cross-sectional surveys of student caregivers in 22 school pairs (2017 survey, N = 6,070; 2018 survey, N = 6,507). We estimated the incidence of laboratory-confirmed influenza hospitalization from 2011 to 2018 using surveillance data from school district zip codes. We analyzed student absenteeism data from 2011 to 2018 from each district (N = 42,487,816 student-days). To account for pre-intervention differences between districts, we estimated difference-in-differences (DID) in influenza hospitalization incidence and absenteeism rates using generalized linear and log-linear models with a population offset for incidence outcomes. Prior to the SLIV intervention, the median household income was $51,849 in the intervention site and $61,596 in the comparison site. The population in each site was predominately white (41% in the intervention site, 48% in the comparison site) and/or of Hispanic or Latino ethnicity (26% in the intervention site, 33% in the comparison site). The number of students vaccinated by the SLIV intervention ranged from 7,502 to 10,106 (22%-28% of eligible students) each year. During the intervention, influenza vaccination coverage among elementary students was 53%-66% in the comparison district. Coverage was similar between the intervention and comparison districts in influenza seasons 2014-2015 and 2015-2016 and was significantly higher in the intervention site in seasons 2016-2017 (7%; 95% CI 4, 11; p < 0.001) and 2017-2018 (11%; 95% CI 7, 15; p < 0.001). During seasons when vaccination coverage was higher among intervention schools and the vaccine was moderately effective, there was evidence of statistically significant indirect effects: The DID in the incidence of influenza hospitalization per 100,000 in the intervention versus comparison site was -17 (95% CI -30, -4; p = 0.008) in 2016-2017 and -37 (95% CI -54, -19; p < 0.001) in 2017-2018 among non-elementary-school-aged individuals and -73 (95% CI -147, 1; p = 0.054) in 2016-2017 and -160 (95% CI -267, -53; p = 0.004) in 2017-2018 among adults 65 years or older. The DID in illness-related school absences per 100 school days during the influenza season was -0.63 (95% CI -1.14, -0.13; p = 0.014) in 2016-2017 and -0.80 (95% CI -1.28, -0.31; p = 0.001) in 2017-2018. Limitations of this study include the use of an observational design, which may be subject to unmeasured confounding, and caregiver-reported vaccination status, which is subject to poor recall and low response rates. A city-wide SLIV intervention in a large, diverse urban population was associated with a decrease in the incidence of laboratory-confirmed influenza hospitalization in all age groups and a decrease in illness-specific school absence rate among students in 2016-2017 and 2017-2018, seasons when the vaccine was moderately effective, suggesting that the intervention produced indirect effects. Our findings suggest that in populations with moderately high background levels of influenza vaccination coverage, SLIV programs are associated with further increases in coverage and reduced influenza across the community.

Background Monitoring of the expanded program on immunization’s performance is not only limited to routine periodic reports but equally includes surveys. Based on unpublished national EPI surveillance data from the past 5 years in Cameroon, the Foumban health district has reported a high number of vaccine preventable disease suspected cases. Contradictory information on the immunization coverage in this district exists from both administrative data and published literature. As a result, the objective of this study was to estimate the immunization coverage and dropout rate in age group 12–23 months and timeliness in age group 0–59 months among children in Foumban Health District (Cameroon), in 2018. Method This was a descriptive cross-sectional study targeting randomly selected children aged 0–59 months from Foumban health district. Data were collected by trained and supervised surveyors using a pretested questionnaire to describe the immunization coverage, timeliness and dropout rate in eighty clusters of about thirty buildings selected by stratified random sampling in July 2018. Results In total, 80 clusters covering 2121 buildings were selected and all were reached (100%). A total of 1549 (81.2%) households accepted to participate in the survey and 1430 children aged 0–59 months including 294 (20.6%) aged 12–23 months were enrolled into the study. Of these 1430 children, 427 [29.9 (27.4–32.2)%] aged 0–59 months were vaccinated with evidence. In the age group 12–23 months, the immunization coverage with evidence of BCG, DPT-Hi + Hb 3 and measles/rubella were 28.6(23.4–33.9)%, 22.8 (18.1–27.6)% and 14.3 (10.3–18.1)% respectively. Within age group 0–59 months; the proportion of children who missed their vaccination appointments increased from 23.3 to 31.7% for the vaccine planned at birth (BCG) and last vaccine planned (Measles/Rubella) for the EPI program respectively. In age group 12–23 months; the specific (DPT-Hi + Hb1–3) and general (BCG-Measles/Rubella) dropout rates of vaccination with evidence were 14.1 and 50.0% respectively. Conclusion Documented immunization coverage, dropout rate and timeliness in Foumban Health district are lower than that targeted by the Cameroon EPI. Competent health authorities have to take necessary actions to ensure the implementation of national guidelines with regards to children access to immunization. Also, studies have to be conducted to identify determinants of low immunization coverage and delays in immunization schedules as well as high dropout rates.

•Geostatistical models showing strong predictive performance are used to produce maps of measles vaccination coverage at 1 × 1 km resolution.•Remoteness, measured as travel time to nearest major settlement, was consistently a key predictor of coverage.•The maps reveal heterogeneities and ‘coldspots’ of low vaccination coverage that are missed using large area summaries.•Aggregated estimates of coverage that do not account for local heterogeneities potentially over-estimate the numbers of children vaccinated by over 10%.•Relating to the WHO GVAP targets of 80% coverage, the integration of high resolution coverage and population maps shows the districts that have attained the threshold in the study countries. The expansion of childhood vaccination programs in low and middle income countries has been a substantial public health success story. Indicators of the performance of intervention programmes such as coverage levels and numbers covered are typically measured through national statistics or at the scale of large regions due to survey design, administrative convenience or operational limitations. These mask heterogeneities and ‘coldspots’ of low coverage that may allow diseases to persist, even if overall coverage is high. Hence, to decrease inequities and accelerate progress towards disease elimination goals, fine-scale variation in coverage should be better characterized. Using measles as an example, cluster-level Demographic and Health Surveys (DHS) data were used to map vaccination coverage at 1 km spatial resolution in Cambodia, Mozambique and Nigeria for varying age-group categories of children under five years, using Bayesian geostatistical techniques built on a suite of publicly available geospatial covariates and implemented via Markov Chain Monte Carlo (MCMC) methods. Measles vaccination coverage was found to be strongly predicted by just 4–5 covariates in geostatistical models, with remoteness consistently selected as a key variable. The output 1 × 1 km maps revealed significant heterogeneities within the three countries that were not captured using province-level summaries. Integration with population data showed that at the time of the surveys, few districts attained the 80% coverage, that is one component of the WHO Global Vaccine Action Plan 2020 targets. The elimination of vaccine-preventable diseases requires a strong evidence base to guide strategies and inform efficient use of limited resources. The approaches outlined here provide a route to moving beyond large area summaries of vaccination coverage that mask epidemiologically-important heterogeneities to detailed maps that capture subnational vulnerabilities. The output datasets are built on open data and methods, and in flexible format that can be aggregated to more operationally-relevant administrative unit levels.

•Globally, distribution of seasonal influenza vaccine doses is trending upwards.•Inequities persist in distribution of seasonal influenza vaccine across WHO regions.•The rollout of Covid-19 vaccines may further impede influenza vaccination uptake.•Countries may use the Covid-19 pandemic to improve existing immunization systems.•Support to countries is critical for optimizing the benefits of influenza vaccines. Sustainable demand for seasonal influenza vaccines is a component of national security strategies for pandemic preparedness. However, the ongoing COVID-19 pandemic has revealed many weaknesses in the capacity of countries to design and execute sustainable vaccination programs. An influenza pandemic remains a global threat and yet there is no global monitoring system for assessing progress towards influenza vaccination coverage targets. The International Federation of Pharmaceutical Manufacturers and Associations’ (IFPMA) Influenza Vaccine Supply International Task Force (IVS) developed a survey method in 2008 to estimate seasonal influenza vaccination coverage rates, which in turn serves as a crude estimate of pandemic preparedness. It provides evidence to guide expanded efforts for pandemic preparedness, specifically for increasing COVID-19 vaccine immunization levels. Furthermore, the results presented herein serve as a proxy for assessing the state of pandemic preparedness at a global and regional level. This paper adds data from 2018 and 2019 to the previous analyses. The current data show an upward or stable global trend in seasonal influenza vaccine dose distributed per 1,000 population with a 7% increase between 2017 and 2018 and 6% increase between 2018 and 2019. However, considerable regional inequities in access to vaccine persist. Three regions, Africa, the Middle-east, and Southeast Asia together account for 50% of the global population but only 6% of distributed seasonal influenza vaccine doses. This is an important finding in the context of the ongoing COVID-19 pandemic, as distribution of influenza vaccine doses in many ways reflects access to COVID-19 vaccines. Moreover, improving seasonal vaccine uptake rates is critical for optimizing the annual benefits by reducing the huge annual influenza-associated societal burdens and by providing protection to vulnerable individuals against serious complications from seasonal influenza infections.