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Unholy night
Depicts the lives of the Three Kings of the Nativity, casting them as a set of infamous thieves who accidentally happen upon Joseph, Mary, and the newborn king and help them escape to Egypt.
Book
Adherens Junction and E-Cadherin complex regulation by epithelial polarity
E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology. While their adhesive role requires these structures to remain stable, AJs are also extremely plastic. This plasticity allows for the adaptation of the cell to its changing environment: changes in neighbors after cell division, cell death, or cell movement, and changes in cell shape during differentiation. In this review we focus on the recent advances highlighting the critical role of the apico-basal polarity machinery, and in particular of the Par3/Bazooka scaffold, in the regulation and remodeling of AJs. We propose that by regulating key phosphorylation events on the core E-Cadherin complex components, Par3 and epithelial polarity promote meta-stable protein complexes governing the correct formation, localization, and functioning of AJ.
Journal Article
Magic in the cloister : pious motives, illicit interests, and occult approaches to the medieval universe
During the late thirteenth and early fourteenth centuries a group of monks with occult interests donated what became a remarkable collection of more than thirty magic texts to the library of the Benedictine abbey of St. Augustine's in Canterbury. The monks collected texts that provided positive justifications for the practice of magic and books in which works of magic were copied side by side with works of more licit genres. In Magic in the Cloister, Sophie Page uses this collection to explore the gradual shift toward more positive attitudes to magical texts and ideas in medieval Europe. She examines what attracted monks to magic texts, works, and how they combined magic with their intellectual interests and monastic life. By showing how it was possible for religious insiders to integrate magical studies with their orthodox worldview, Magic in the Cloister contributes to a broader understanding of the role of magical texts and ideas and their acceptance in the late Middle Ages.
eBook
Magic, Body and the Self in Eighteenth-Century Sweden
Providing a unique insight into early modern notions of body and self, this book offers a comprehensive interpretation of Swedish witchcraft in the eighteenth century and its endurance as every day social practice in the age of Enlightenment.
eBook
MAGI-ACMG: Algorithm for the Classification of Variants According to ACMG and ACGS Recommendations
We have developed MAGI-ACMG, a classification algorithm that allows the classification of sequencing variants (single nucleotide or small indels) according to the recommendations of the American College of Medical Genetics (ACMG) and the Association for Clinical Genomic Science (ACGS). The MAGI-ACMG classification algorithm uses information retrieved through the VarSome Application Programming Interface (API), integrates the AutoPVS1 tool in order to evaluate more precisely the attribution of the PVS1 criterion, and performs the customized assignment of specific criteria. In addition, we propose a sub-classification scheme for variants of uncertain significance (VUS) according to their proximity either towards the “likely pathogenic” or “likely benign” classes. We also conceived a pathogenicity potential criterion (P_POT) as a proxy for segregation criteria that might be added to a VUS after posterior testing, thus allowing it to upgrade its clinical significance in a diagnostic reporting setting. Finally, we have developed a user-friendly web application based on the MAGI-ACMG algorithm, available to geneticists for variant interpretation.
Journal Article
Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity
WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite sequence specificity. Via systematic structural biology and biochemistry approaches, we decoded the target binding rules of WW domain tandems from cell growth regulatory proteins and uncovered a list of previously unknown WW tandem binding proteins including β-Dystroglycan, JCAD, and PTPN21. The WW tandem-mediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes including neuronal synaptic signaling.
Journal Article
Implications of The Gift of the Magi for Moral Education of Teenagers From the Perspective of Interaction Ritual Chains
Adolescence is a pivotal moment in shaping one's character and holds great implications for one's values and personal growth. The Gift of the Magi by O. Henry portrays how an ordinary young couple in difficult financial circumstances managed to show their love for each other, eulogizing truth, goodness, and beauty in humanity. We conducted a thorough examination of the significance of moral values conveyed in The Gift of the Magi for teenager education using the \"situation-emotion-symbol\" model that is based on Randall Collins' theory of interaction ritual chains in order to establish an interaction ritual chain model for moral education of teenagers. Our study reveals that situated cognition is useful in constructing the focus of attention for the moral education of teenagers; that shared emotion is the driving force for achieving moral education of teenagers; and that symbolic connections help teenagers put the virtues they've learned from The Gift of the Magi into action and provides effective measures that can significantly contribute to the cultivation and implementation of moral education among teenagers.
Journal Article
Parthian moγ and Middle Persian moγ/mow in Light of Earlier Eastern and Western Iranian Sources
The present article analyses the historical importance assumed by Parthian and Middle Persian moγ/mow (and related words) in the framework of the religious and administrative language of Late Antiquity despite its seemingly absolute absence in the Avestan Sprachgut. Although moγ should be reasonably considered as a word of (prominent) Western Iranian derivation, i.e. from Median and Old Persian magu-, the progressive phonetic evolution toward a spelling, such as that of early Parthian and Middle Persian *moγ(u)- created a fitting resonance with a rare Avestan word (in its turn probably nonexistent in the older strata of the language, if not even a Western loanword itself), specifically moγu-°, which is attested only in the Y.Av. compound moγu.tb̰ iš-. The rising weight assumed by the priestly college of the Magi in secular activities already during the Achaemenian period promoted the preservation of this title also after the diffusion of the Avestan liturgy in Western Iran. This development also ensured that the designation of *moγ(u)- became extended to the whole family of the Zoroastrian priests following the Avestan tradition.
Journal Article
A Phylogenomic Investigation into the Origin of Metazoa
The evolution of multicellular animals (Metazoa) from their unicellular ancestors was a key transition that was accompanied by the emergence and diversification of gene families associated with multicellularity. To clarify the timing and order of specific events in this transition, we conducted expressed sequence tag surveys on 4 putative protistan relatives of Metazoa including the choanoflagellate Monosiga ovata, the ichthyosporeans Sphaeroforma arctica and Amoebidium parasiticum, and the amoeba Capsaspora owczarzaki, and 2 members of Amoebozoa, Acanthamoeba castellanii and Mastigamoeba balamuthi. We find that homologs of genes involved in metazoan multicellularity exist in several of these unicellular organisms, including 1 encoding a membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI) in Capsaspora. In Metazoa, MAGI regulates tight junctions involved in cell-cell communication. By phylogenomic analyses of genes encoded in nuclear and mitochondrial genomes, we show that the choanoflagellates are the closest relatives of the Metazoa, followed by the Capsaspora and Ichthyosporea lineages, although the branching order between the latter 2 groups remains unclear. Understanding the function of \"metazoan-specific\" proteins we have identified in these protists will clarify the evolutionary steps that led to the emergence of the Metazoa. [PUBLICATION ABSTRACT]
Journal Article
A new metaphor-less optimization algorithm for synthesis of mechanisms
This paper proposes a novel metaphor-less optimization algorithm which makes use of maximum and minimum values obtained in the current candidate group and their interaction, hence it is named as max–min-greedy-interaction (MaGI) algorithm. The algorithm begins with the candidate group initialization and identification of maximum and minimum values of candidates. These values are utilized during updation and greedy interaction among the candidates. The proposed algorithm is also applied to synthesize four-bar linkage for prescribed path. It is reported that the MaGI performs better in comparison with the contemporary and well-established algorithms. The algorithm’s effectiveness and performance have been validated on three unimodal unconstrained functions (for exploitation ability), three constrained, and three non-trivial mechanism problems (for exploration ability) which makes the algorithm acceptable and reliable for varied applications.
Journal Article