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This is a Brighton Collaboration Case Definition of the term “Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)” to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.

Sunlight is the most abundant and inexhaustible energy source on earth. However, its low energy density, dispersibility and intermittent nature make its direct utilization with industrial relevance challenging, suggesting that converting sunlight into chemical energy and storing it is a valuable measure to achieve global sustainable development. Carbon–neutral, clean and secondary pollution-free solar-driven water splitting to produce hydrogen is one of the most attractive avenues among all the current options and is expected to realize the transformation from dependence on fossil fuels to zero-pollution hydrogen. Artificial photosynthetic systems (APSs) based on photoelectrochemical (PEC) devices appear to be an ideal avenue to efficiently achieve solar-to-hydrogen conversion. In this review, we comprehensively highlight the recent developments in photocathodes, including architectures, semiconductor photoabsorbers and performance optimization strategies. In particular, frontier research cases of organic semiconductors, dye sensitization and surface grafted molecular catalysts applied to APSs based on frontier (molecular) orbital theory and semiconductor energy band theory are discussed. Moreover, research advances in typical photoelectrodes with the metal–insulator–semiconductor (MIS) architecture based on quantum tunnelling are also introduced. Finally, we discuss the benchmarks and protocols for designing integrated tandem photoelectrodes and PEC systems that conform to the solar spectrum to achieve high-efficiency and cost-effective solar-to-hydrogen conversion at an industrial scale in the near future.

This study was performed to prospectively compare the clinical and radiographic outcomes between robot-assisted minimally invasive transforaminal lumbar interbody fusion (RA MIS-TLIF) and fluoroscopy-assisted minimally invasive transforaminal lumbar interbody fusion (FA MIS-TLIF) in patients with degenerative lumbar spinal diseases. One hundred and twenty-three patients with lumbar degenerative diseases (lumbar spinal stenosis with instability and spondylolisthesis [degenerative spondylolisthesis or isthmic spondylolisthesis]) who underwent MIS-TLIF in our hospital were included in this study. Sixty-one patients underwent RA MIS-TLIF (Group A) and 62 patients underwent FA MIS-TLIF (Group B). Group A was further divided into Subgroup AI (46 single-level procedures) and Subgroup AII (15 double-level procedures). Group B was further divided into Subgroup BI (45 single-level procedures) and Subgroup BII (17 double-level procedures). The clinical outcome parameters were the visual analog scale (VAS) score, Oswestry Disability Index (ODI) score, operative time, number of intraoperative fluoroscopies, blood loss, postoperative hospital stay, and postoperative complications. The radiographic change measures were the accuracy of screw placement, facet joint violation (FJV), fusion status, and change in disc height at the proximal adjacent segment at the 2-year follow-up. There were no significant differences in the VAS and ODI scores, blood loss, or postoperative hospital stay between Groups A and B ( p > 0.05). The operative time was longer in Group A than B ( p = 0.018). The operative time was longer in Subgroup AI than BI ( p = 0.001). However, there was no significant difference between Subgroups AII and BII ( p > 0.05). There was no significant difference in the number of intraoperative fluoroscopies for patients between Groups A and B ( p > 0.05). Although the number of intraoperative fluoroscopies for patients was significantly higher in Subgroup AI than BI ( p = 0.019), there was no significant difference between Subgroups AII and BII ( p > 0.05). The number of intraoperative fluoroscopies for the surgeon was significantly lower in Group A than B ( p < 0.001). For surgeons, the difference in the average number of intraoperative fluoroscopies between Subgroups AI and AII was 2.98, but that between Subgroups BI and BII was 10.73. In Group A, three guide pins exhibited drift and one patient developed a lateral wall violation by a pedicle screw. One pedicle screw perforated the anterior wall of the vertebral body and another caused an inner wall violation in Group B. The rate of a perfect screw position (grade A) was higher in Group A than B ( p < 0.001). However, there was no significant difference in the proportion of clinically acceptable screws (grades A and B) between the two groups. The mean FJV grade was significantly higher in Group B than A ( p < 0.001). During at 2-year postoperative follow-up, there was no significant difference in the fusion status between the two groups ( p > 0.05); however, the decrease in disc height at the proximal adjacent segment was significantly less in Group A than B ( p < 0.001). Robot-assisted percutaneous pedicle screw placement is a safer and more accurate alternative to conventional freehand fluoroscopy-assisted percutaneous pedicle screw insertion in MIS-TLIF.

Based on the analysis of the geological context and palynological studies performed on lake and bog sediments in the Southern Podlasie Lowland, a new concept of the maximum extent of the Odranian Glaciation (Saalian, MIS 6) is presented for the study area. It is depicted by the Siedlce−Łosice−Kornica zone of end moraines, which so far was considered as stadial-rank or as the Wartanian ice sheet limit. To the south of this zone, near Biała Podlaska and in the Łuków Plain, there occur numerous sites with fossil deposits of the Mazovian Interglacial (MIS 11c). Sites with new documentation, i.e., Wólka Domaszewska, Kolonia Bystrzycka, Przytulin, Hermanów, and Skrzynka are located about 30 km to the south and 60 km to the west of the Biała Podlaska area. Palynological analysis unequivocally indicates the presence of a vegetation succession characteristic of the Mazovian Interglacial. In all sites, deposits of the Mazovian Interglacial are covered by lacustrine sediments of the Liviecian Glaciation (Fuhne, MIS 11b-MIS 10) or mineral sediments of the Vistulian Glaciation (Weichselian, MIS 2) and the Holocene. The sediments infill paleolakes carved in glacial tills of the Sanian 2 Glaciation (MIS 12). The lake sediments of the Mazovian Interglacial and the overlying biogenic and mineral deposits occur in the analysed sites directly below the surface. They are never covered by glacial deposits, which suggests that the Odranian ice sheet did not cover the study area. The location of the lake and bog sites with their geological analysis allow for the precise depiction of the eastern limit of the Odranian ice sheet lobe, which in the study area correlates with the limit suggested in the late 19th century. The Odranian ice sheet did not cover Southern Podlasie.

[...]our results showed that exon skipping occurred due to the CRISPR/Cas9‐mediated alterations at the splice site of a plant gene. [...]we found the exon 2 removal during the splicing process in the Rbadh2ΔG and Rbadh2ΔAAG mutants caused shifting of reading frame in the processed mRNA, resulting in a PTC in the exon 3 (Figure 1g). The transcripts containing a PTC will be degraded by non‐sense‐mediated decay (Capito et al., 2018), as indicated by the reduced expression level of the mutated Osbadh2 compared with the WT (Figure 1d, h). Since loss of OsBADH2 function promotes accumulation of 2AP, we explored the consequence of Osbadh2 exon 2 skipping on the 2AP content in grains of the homozygous transgene‐free plants of Rbadh2ΔG and Rbadh2ΔAAG using gas chromatography–mass spectrometry (GC‐MS). [...]this study provides the first evidence that CRISPR/Cas9‐mediated deletion of the exonic nucleotide at the exon–intron junction of a plant gene could cause exon skipping during pre‐mRNA splicing.

Background: Vasculitis diseases include Kawasaki disease (KD), Kawasaki disease shock syndrome (KDSS), Multisystem Inflammatory Syndrome (MIS), Henoch–Schönlein purpura (HS), or IgA vasculitis, and additional vasculitis diseases. These diseases are often preceded by infections or immunizations. Disease incidence rates are higher in children than in adults. These diseases have been extensively studied, but understanding of the disease etiology remains to be established. Objective: Many studies have failed to demonstrate an association between vasculitis diseases and vaccination; this study examines possible associations. Methods: Herein, the Vaccine Adverse Event Reporting System (VAERS) database is retrospectively examined for associations between vasculitis diseases and immunizations. Results: For some vaccines, the number of rare cases of KD, MIS, and HS are higher than the background rates. These rare cases are predicted to occur in individuals with (1) genetic risk factors with (2) antibody titer levels above the primary immune response level. Herein, the model of humoral immune response antibodies bound to antigens (pathogen or vaccine) creating immune complexes is proposed. These immune complexes are proposed to bind Fc receptors on immune cells and platelets, resulting in cell activation and the release of inflammatory molecules including histamine and serotonin. Immune complexes and inflammatory molecules including serotonin and histamine likely trigger vasculitis. Elevated serotonin and possibly histamine drive initial vasoconstrictions, disrupting blood flow. Increased blood flow pressure from cardiac capillary vasoconstrictions is predicted to trigger coronary artery aneurysms (CAA) or lesions (CAL) in some patients. For KDSS and MIS patients, these cardiac capillary vasoconstrictions are predicted to result in ischemia followed by ventricular dysfunction. Ongoing ischemia can result in long-term cardiac damage. Cases associated with pathogens are likely to have persistent infections triggering disease onset. Conclusion: The proposed model of immune complexes driving disease initial disease etiology by Fc receptor activation of immune cells and platelets, resulting in elevated histamine and serotonin levels, is testable and is consistent with disease symptoms and current treatments.

Each injection of any known vaccine results in a strong expression of pro-inflammatory cytokines. This is the result of the innate immune system activation, without which no adaptive response to the injection of vaccines is possible. Unfortunately, the degree of inflammation produced by COVID-19 mRNA vaccines is variable, probably depending on genetic background and previous immune experiences, which through epigenetic modifications could have made the innate immune system of each individual tolerant or reactive to subsequent immune stimulations.We hypothesize that we can move from a limited pro-inflammatory condition to conditions of increasing expression of pro-inflammatory cytokines that can culminate in multisystem hyperinflammatory syndromes following COVID-19 mRNA vaccines (MIS-V). We have graphically represented this idea in a hypothetical inflammatory pyramid (IP) and we have correlated the time factor to the degree of inflammation produced after the injection of vaccines. Furthermore, we have placed the clinical manifestations within this hypothetical IP, correlating them to the degree of inflammation produced. Surprisingly, excluding the possible presence of an early MIS-V, the time factor and the complexity of clinical manifestations are correlated to the increasing degree of inflammation: symptoms, heart disease and syndromes (MIS-V).

The timing and duration of the coldest period in the last glacial stage, often referred to as the last glacial maximum (LGM), has been observed to vary spatially and temporally. In Australia, this period is characterised by colder, and in some places more arid, climates than today. We applied Monte-Carlo change point analysis to all available continuous proxy records covering this period, primarily pollen records, from across Australia (n = 37) to assess this change. We find a significant change point occurred (within uncertainty) at 28.6 ± 2.8 ka in 25 records. We interpret this change as a shift to cooler climates, associated with a widespread decline in biological productivity. An additional change point occurred at 17.7 ± 2.2 ka in 24 records. We interpret this change as a shift towards warmer climates, associated with increased biological productivity. We broadly characterise the period between 28.6 (± 2.8) – 17.7 (± 2.2) ka as an extended period of maximum cooling, with low productivity vegetation that may have occurred as a combined response to reduced temperatures, lower moisture availability and atmospheric CO2. These results have implications for how the spatial and temporal coherence of climate change, in this case during the LGM, can be best interrogated and interpreted.

Electrical characteristics of the Au/Si3N4/4H n-SiC metal–insulator-semiconductor (MIS) diode were investigated under the temperature, T, interval of 160–400 K using current–voltage (I–V), capacitance–voltage (C-V) and conductance–voltage (G/ω-V) measurements. Firstly, the Schottky diode parameters as zero-bias barrier height (ΦB0) and ideality factor (n) were calculated according to the thermionic emission (TE) from forward bias I–V analysis in the whole working T. Experimental results showed that the values of ΦB0 were in increasing behavior with increasing T while n values decreased with inverse proportionality in n versus ΦB0 plot. Therefore, the non-ideal I–V behavior with inhomogeneous barrier height (BH) formation has been discussed under the assumption of Gaussian distribution (GD). From the GD of BHs, the mean BH was found to be about 1.40 eV with 0.1697 standard deviation and the modified Richardson constant A∗ of this diode was obtained as 141.65 A/cm2 K2 in good agreement with the literature (the theoretical value of A∗ is 137.21 A/cm2 K2). The relationship between ΦB0 and n showed an abnormal I–V behavior depending on T, and it was modeled by TE theory with GD of BH due to the effect in inhomogeneous BH at the interface. Secondly, according to Cheung’s model, series resistance, RS values were calculated in the T range of 160–400 K and these values were found to decrease with increasing T. Finally, the density of interface states, Dit was calculated and the T dependence of energy distribution of Dit profiles determined the forward I-V measurements by taking into account the bias dependence of the effective BH, Φe and n. Dit were also calculated according to the Hill–Coleman method from C-V and G/ω-V analysis. Furthermore, the variation of Dit as a function of frequency, f and T were determined.