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Several initiatives have been proposed to mitigate forest loss and climate change through tree planting as well as maintaining and restoring forest ecosystems. These initiatives have both inspired and been inspired by global assessments of tree and forest attributes and their contributions to offset carbon dioxide (CO₂) emissions. Here we use data from more than 130,000 national forest inventory plots to describe the contribution of nearly 1.4 trillion trees on forestland in the conterminous United States to mitigate CO₂ emissions and the potential to enhance carbon sequestration capacity on productive forestland. Forests and harvested wood products uptake the equivalent of more than 14% of economy-wide CO₂ emissions in the United States annually, and there is potential to increase carbon sequestration capacity by ∼20% (−187.7 million metric tons [MMT] CO₂ ±9.1 MMT CO₂) per year by fully stocking all understocked productive forestland. However, there are challenges and opportunities to be considered with tree planting. We provide context and estimates from the United States to inform assessments of the potential contributions of forests in climate change mitigation associated with tree planting.

Underground hydrogen storage is a long‐duration energy storage option for a low‐carbon economy. Although research into the technical feasibility of underground hydrogen storage is ongoing, existing underground gas storage (UGS) facilities are appealing candidates for the technology because of their ability to store and deliver natural gas. We estimate that UGS facilities in the United States (U.S.) can store 327 TWh (9.8 MMT) of pure hydrogen. A complete transition to hydrogen storage would reduce the collective working‐gas energy of UGS facilities by ∼75%; however, most (73.2%) UGS facilities could maintain current energy demand using a 20% hydrogen‐natural gas blend. U.S. UGS facilities can buffer 23.9%–44.6% of the high and low hydrogen demand projected for 2050, respectively, which exceeds the current percentage of natural gas demand buffered by storage. Thus, transitioning UGS infrastructure to hydrogen could substantially reduce the number of new hydrogen storage facilities needed to support a hydrogen economy. Plain Language Summary Hydrogen is a high energy content fuel that can be produced with low or zero greenhouse gas emissions from water and other chemicals. Creating hydrogen during periods of energy surplus and storing it underground is one long‐duration, low‐emission, energy storage option that can balance supply and demand for an entire electric grid. In the United States (U.S.), existing underground gas storage (UGS) facilities are a logical first place to consider subsurface hydrogen storage, because their geology has proven favorable for storing natural gas. We estimated that existing UGS facilities can store 327 TW‐h (9.8 million metric tons) of pure hydrogen. Transitioning from natural gas to pure hydrogen storage would reduce the total energy stored in existing UGS facilities by ∼75%. Storing hydrogen‐natural gas mixtures also reduces energy storage potential, but most (73.2%) UGS facilities can meet current energy demands with a 20% hydrogen blend. U.S. UGS facilities can store 23.9%–44.6% of the projected high and low hydrogen demand for 2050, respectively, suggesting that a partial transition of UGS infrastructure could reduce the need for new hydrogen storage facilities. These findings motivate research that explores the technical feasibility of underground hydrogen storage in natural gas storage reservoirs. Key Points The total hydrogen working‐gas energy of underground gas storage facilities in the United States is estimated to be 327 TW‐hours Most (73.2%) underground gas storage facilities can store hydrogen blends up to 20% and continue to meet their current energy demand Hydrogen storage in existing underground gas storage facilities can sufficiently buffer the hydrogen demand projected for 2050

Ti3C2Tx Quantum dots (QDs)/L‐Ti3C2Tx fiber electrode (Q3M7) with high capacitance and excellent flexibility is prepared by a wet spinning method. The assembled units Ti3C2Tx nanosheets (NSs) with large size (denoted as L‐Ti3C2Tx) is obtained by natural sedimentation screen raw Ti3AlC2, etching, and mechanical delamination. The pillar agent Ti3C2Tx QDs is fabricated by an ultrasound method. Q3M7 fiber electrode gave a specific capacitance of 1560 F cm−3, with a capacity retention rate of 79% at 20 A cm−3, and excellent mechanical strength of 130 Mpa. A wide temperature all‐solid‐state the delaminated montmorillonite (F‐MMT)/Polyvinyl alcohol (PVA) dimethyl sulfoxide (DMSO) flexible hydrogel (DHGE) (F‐MMT/PVA DHGE) Q3M7 fiber supercapacitor is assembled by using Q3M7 fiber as electrodes and F‐MMT/PVA DHGE as electrolyte and separator. It showed a volume specific capacitance of 413 F cm−3 at 0.5 A cm−3, a capacity retention of 97% after 10 000 cycles, an energy density of 36.7 mWh cm−3 at a power density of 311 mW cm−3, and impressive capacitance and flexibility over a wide temperature range of −40 to 60 °C. This work provides an effective strategy for designing and assembling wide temperature all‐solid‐state fiber supercapacitors with optimal balance of capacitive performance and flexibility. Ti3C2Tx Quantum dots (QDs)/L‐Ti3C2Tx fiber electrode (Q3M7) with high capacitance and excellent flexibility is prepared by a wet spinning method, and all‐solid‐state symmetric fiber supercapacitor (F‐MMT/PVA DHGE Q3M7) with excellent energy storage in a wide temperature from ‐40 to 60 °C is assembled on the basis of the optimizing balance of capacitive performance and flexibility.

Loss of reactive nitrogen (N) from agricultural fields in the U.S. Midwest is a principal cause of the persistent hypoxic zone in the Gulf of Mexico. We used eight years of high resolution satellite imagery, field boundaries, crop data layers, and yield stability classes to estimate the proportion of N fertilizer removed in harvest (NUE) versus left as surplus N in 8 million corn ( Zea mays ) fields at subfield resolutions of 30 × 30 m (0.09 ha) across 30 million ha of 10 Midwest states. On average, 26% of subfields in the region could be classified as stable low yield, 28% as unstable (low yield some years, high others), and 46% as stable high yield. NUE varied from 48% in stable low yield areas to 88% in stable high yield areas. We estimate regional average N losses of 1.12 (0.64–1.67) Tg N y −1 from stable and unstable low yield areas, corresponding to USD 485 (267–702) million dollars of fertilizer value, 79 (45–113) TJ of energy, and greenhouse gas emissions of 6.8 (3.4–10.1) MMT CO 2 equivalents. Matching N fertilizer rates to crop yield stability classes could reduce regional reactive N losses substantially with no impact on crop yields, thereby enhancing the sustainability of corn-based cropping systems.

Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung carcinoma (NSCLC) in a TGF‐β1/Smad3 dependent manner. Better understanding its regulatory signaling in tumor microenvironment (TME) may identify druggable target for the development of precision medicine. Here, by dissecting the transcriptome dynamics of tumor‐associated macrophage at single‐cell resolution, a crucial role of a hematopoietic transcription factor Runx1 in MMT formation is revealed. Surprisingly, integrative bioinformatic analysis uncovers Runx1 as a key regulator in the downstream of MMT‐specific TGF‐β1/Smad3 signaling. Stromal Runx1 level positively correlates with the MMT‐derived CAF abundance and mortality in NSCLC patients. Mechanistically, macrophage‐specific Runx1 promotes the transcription of genes related to CAF signatures in MMT cells at genomic level. Importantly, macrophage‐specific genetic deletion and systemic pharmacological inhibition of TGF‐β1/Smad3/Runx1 signaling effectively prevent MMT‐driven CAF and tumor formation in vitro and in vivo, representing a potential therapeutic target for clinical NSCLC.

Renal fibrosis causes structural and functional impairment of the kidney, which is a dominant component of chronic kidney disease. Recently, a novel mechanism, macrophage-to-myofibroblast transition (MMT), has been identified as a crucial component in renal fibrosis as a response to chronic inflammation. It is a process by which bone marrow-derived macrophages differentiate into myofibroblasts during renal injury and promote renal fibrosis. Here, we summarized recent evidence and mechanisms of MMT in renal fibrosis. Understanding this phenomenon and its underlying signal pathway would be beneficial to find therapeutic targets for renal fibrosis in chronic kidney disease.

Background Peritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires the establishment of adhesive interactions between cancer cells and the peritoneal membrane. Interrelations between EOC and the mesothelial stroma are critical to facilitate the metastatic process. No data is available so far on the impact of histone acetylation/deacetylation, a potentially relevant mechanism governing EOC metastasis, on mesothelial cells (MCs)-mediated adhesion. Methods Static adhesion and peritoneal clearance experiments were performed pretreating mesenchymal-like MCs and platinum—sensitive/resistant EOC cell lines with MS-275—a Histone deacetylase (HDAC)1–3 pharmacological inhibitor currently used in combination trials. Results were acquired by confocal microscopy and were analyzed with an automated Opera software. The role of HDAC1/2 was validated by genetic silencing. The role of α4-, α5-α1 Integrins and Fibronectin-1 was validated using specific monoclonal antibodies. Quantitative proteomic analysis was performed on primary MCs pretreated with MS-275. Decellularized matrices were generated from either MS-275-exposed or untreated cells to study Fibronectin-1 extracellular secretion. The effect of MS-275 on β1 integrin activity was assessed using specific monoclonal antibodies. The role of Talin-1 in MCs/EOC adhesion was analyzed by genetic silencing. Talin-1 ectopic expression was validated as a rescue tool from MS-275-induced phenotype. The in vivo effect of MS-275-induced MC remodeling was validated in a mouse model of peritoneal EOC dissemination. Results Treatment of MCs with non-cytotoxic concentrations of MS-275 caused a consistent reduction of EOC adhesion. Proteomic analysis revealed several pathways altered upon MC treatment with MS-275, including ECM deposition/remodeling, adhesion receptors and actin cytoskeleton regulators. HDAC1/2 inhibition hampered actin cytoskeleton polymerization by downregulating actin regulators including Talin-1, impairing β1 integrin activation, and leading to abnormal extracellular secretion and distribution of Fibronectin-1. Talin-1 ectopic expression rescued EOC adhesion to MS-275-treated MCs. In an experimental mouse model of metastatic EOC, MS-275 limited tumor invasion, Fibronectin-1 secretion and the sub-mesothelial accumulation of MC-derived carcinoma-associated fibroblasts. Conclusion Our study unveils a direct impact of HDAC-1/2 in the regulation of MC/EOC adhesion and highlights the regulation of MC plasticity by epigenetic inhibition as a potential target for therapeutic intervention in EOC peritoneal metastasis.

Background Methadone Maintenance Treatment (MMT) is widely recognized as one of the most effective ways of reducing risk of overdose, arrest, and transmission of blood-borne viruses like HIV and HCV among people that use opioids. Yet, MMT’s use of restrictive take-home dose policies that force most patients to attend their clinic on a daily, or near-daily, basis may be unpopular with many patients and lead to low rates of treatment uptake and retention. In response, this article examines how clinics’ take-home dosing policies have affected patients’ experiences of treatment and lives in general. Methods This article is based on semi-structured, qualitative interviews with a variety of stakeholders in MMT. Interviews explored: reasons for engaging with, or not engaging with MMT; how MMT is conceptualized by patients and treatment providers (e.g., as harm reduction or route to abstinence and/or recovery); experiences with MMT; perception of barriers to MMT (e.g., organizational/regulatory, social) and how MMT might be improved to support peoples’ substance use treatment needs and goals. Results Nearly all of the patients with past or present MMT use were highly critical of the limited access to take-home doses and consequent need for daily or near daily clinic attendance. Participants described how the use of restrictive take-home dose policies negatively impacted their ability to meet day-to-day responsibilities and also cited the need for daily attendance as a reason for quitting or avoiding OAT. Responses also demonstrate how such policies contribute to an environment of cruelty and stigma within many clinics that exposes this already-stigmatized population to additional trauma. Conclusions Take-home dose policies in MMT are not working for a substantial number of patients and are reasonably seen by participants as degrading and dehumanizing. Revision of MMT regulations and policies regarding take home doses are essential to improve patient satisfaction and the quality and effectiveness of MMT as a key evidence-based treatment and harm reduction strategy.

The primary objective of mineral exploration is to discover new mineral-rich zones within targeted regions. The fractal concentration area (C-A) and the magnetic maps are now extensively used in mineral prospecting. Unfortunately, the calculation of the reduced-to-pole (RTP) maps suffers from several drawbacks. It requires a prior knowledge of the inclination and declination of the source magnetization. It can be complicated to determine the direction of the source magnetization vector in certain conditions because of the large and significant remanent magnetization of the source if present. Furthermore, at low magnetic latitudes, the RTP computation is unstable. However, a new class of transforms known as magnitude magnetic transforms (MMTs) overcome these drawbacks. Such transforms have nonnegative distributions and exhibit significantly higher centricity with regard to the observed anomalous field. Their anomaly patterns are much less influenced by the direction of the magnetization vector than the observed total magnetic intensity. Due to these benefits, in this work, these transforms are used instead of RTP transform as a base for fractal/multifractal analysis of the magnetic signal from the Esh El Mallaha area, Eastern desert to delineate gold mineralization and hydrothermally altered and potential zones. Moreover, are used for the singularity analysis S-A in a novel integrated workflow. The results of this study show a promising approach that can be utilized globally for mineralization detection strategies.

Abstract The U.S. dairy industry considerably reduced environmental impacts between 1944 and 2007, primarily through improved dairy cow productivity. However, although milk yield per cow has increased over the past decade, whole-system environmental impact analyses have not been conducted over this time period, during which environmental modeling science has improved considerably. The objective of this study was to compare the environmental impact of U.S. dairy cattle production in 2007–2017. A deterministic model based on population demographics, metabolism, and nutrient requirements of dairy cattle was used to estimate resource inputs, nutrient excretion, and greenhouse gas (GHG) emissions per 1.0 × 106 t (one million metric t or MMT) of energy-corrected milk (ECM) produced in 2007 and 2017. System boundaries extended from the manufacture and transport of cropping inputs to milk at the farm gate. Milk transport, processing, and retail were not included. Dairy systems were modeled using typical management practices, herd population dynamics, and production data from U.S. dairy farms. Cropping data were sourced from national databases. The resources required to produce 1.0 MMT ECM in 2017 were considerably reduced relative to those required in 2007, with 2017 production systems using 74.8% of the cattle, 82.7% of the feedstuffs, 79.2% of the land, and 69.5% of the water as compared to 2007. Waste outputs were similarly reduced, with the 2017 U.S. dairy industry producing 79.4%, 82.5%, and 85.7% of the manure, N, and P excretion, respectively. Dairy production in 2017 emitted 80.9% of the CH4 and 81.5% of the N2O per 1.0 MMT ECM compared to 2007. Enteric and manure emissions contributed the major proportion (80%) of GHG emissions per unit of milk, with lesser contributions from cropping (7.6%) and fertilizer application (5.3%). The GHG emissions per 1.0 MMT ECM produced in 2017 were 80.8% of equivalent milk production in 2007. Consequently, although total U.S. ECM production increased by 24.9% between 2007 and 2017, total GHG emissions from this milk production increased by only 1.0%. In line with previous historical analyses, the U.S. dairy industry has made remarkable productivity gains and environmental progress over time. To maintain this culture of continuous improvement, the dairy industry must build on gains made to date and demonstrate its commitment to reducing environmental impacts while improving both economic viability and social acceptability.