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On the Integration of In Silico Drug Design Methods for Drug Repurposing
Drug repurposing has become an important branch of drug discovery. Several computational approaches that help to uncover new repurposing opportunities and aid the discovery process have been put forward, or adapted from previous applications. A number of successful examples are now available. Overall, future developments will greatly benefit from integration of different methods, approaches and disciplines. Steps forward in this direction are expected to help to clarify, and therefore to rationally predict, new drug-target, target-disease, and ultimately drug-disease associations.
Journal Article
Development of a bulk cargo fruit sampler
The design of an agricultural machine or equipment can be considered of great complexity, due to the interactions between the operator, the machine, the product and the environment. There is a lack of available technologies for collecting fruit in bulk cargo at any time from transport to industries. A limiting factor is the loading of fruits that are at the base of the cargo. This study was carried out to develop a detailed design of a bulk cargo fruit sampler that can collect fruits in any position of the x, y and z axes. A methodology was applied and adapted to execute the design. This methodology was divided into the following stages: design planning, informational design, conceptual design, preliminary design and detailed design. The variant considered the most appropriate was selected for the preliminary design and detailed design. The concepts were divided into chassis or support, sample collector and support for sample removal. The removal of fruits was carried out to maintain as much of their interaction with the environment outside the collector as possible. With the conclusion of the detailed design, it was possible to file, at the National Institute of Industrial Property, the patent for the collector of fruit samples in bulk cargo. Results obtained from fruits in the collector were used in doctoral theses.
Journal Article
Machine Design with CAD and Optimization
MACHINE DESIGN WITH CAD AND OPTIMIZATION A guide to the new CAD and optimization tools and skills to generate real design synthesis of machine elements and systems Machine Design with CAD and Optimization offers the basic tools to design or synthesize machine elements and assembly of prospective elements in systems or products.
eBook
Sustainable Development in Mechanical Engineering
Due to their specialized training, engineers play a crucial role in the design and development of new products and infrastructure, as well as in the creation of wealth. Consequently, engineers recognize that they have a specific responsibility in the performance of these functions to take such measures as are appropriate to safeguard the environment, health, safety and well-being of the public. This book proposes a series of sixteen practical cases, integrating knowledge from different fields.
eBook
A Review on Additive Manufacturing Possibilities for Electrical Machines
This paper presents current research trends and prospects of utilizing additive manufacturing (AM) techniques to manufacture electrical machines. Modern-day machine applications require extraordinary performance parameters such as high power-density, integrated functionalities, improved thermal, mechanical & electromagnetic properties. AM offers a higher degree of design flexibility to achieve these performance parameters, which is impossible to realize through conventional manufacturing techniques. AM has a lot to offer in every aspect of machine fabrication, such that from size/weight reduction to the realization of complex geometric designs. However, some practical limitations of existing AM techniques restrict their utilization in large scale production industry. The introduction of three-dimensional asymmetry in machine design is an aspect that can be exploited most with the prevalent level of research in AM. In order to take one step further towards the enablement of large-scale production of AM-built electrical machines, this paper also discusses some machine types which can best utilize existing developments in the field of AM.
Journal Article