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"Maids"
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Maid for Television
Honorable Mention -- Association for Asian American Studies Book Award in the Media, Performance, and Visual Studies category Maid for Television examines race, class, and gender relations as embodied in a long history of television servants from 1950 to the turn of the millennium. Although they reside at the visual peripheries, these figures are integral to the idealized American family. Author L. S. Kim redirects viewers' gaze towards the usually overlooked interface between characters, which is drawn through race, class, and gender positioning. Maid for Television tells the stories of servants and the families they work for, in so doing it investigates how Americans have dealt with difference through television as a medium and a mediator.The book philosophically redirects the gaze of television and its projection of racial discourse.
eBook
Love comes later
An unexpected discovery forces an undocumented motel employee to make a life changing decision. Starring Orange Is the New Black-actress Diane Guerrero, and Homeland actress Sarita Choudhury.
Streaming Video
Human semen contains exosomes with potent anti-HIV-1 activity
Background
Exosomes are membranous nanovesicles secreted into the extracellular milieu by diverse cell types. Exosomes facilitate intercellular communication, modulate cellular pheno/genotype, and regulate microbial pathogenesis. Although human semen contains exosomes, their role in regulating infection with viruses that are sexually transmitted remains unknown. In this study, we used semen exosomes purified from healthy human donors to evaluate the role of exosomes on the infectivity of different strains of HIV-1 in a variety of cell lines.
Results
We show that human semen contains a heterologous population of exosomes, enriched in mRNA encoding tetraspanin exosomal markers and various antiviral factors. Semen exosomes are internalized by recipient cells and upon internalization, inhibit replication of a broad array of HIV-1 strains. Remarkably, the anti-HIV-1 activity of semen exosomes is specific to retroviruses because semen exosomes blocked replication of the murine AIDS (mAIDS) virus complex (LP-BM5). However, exosomes from blood had no effect on HIV-1 or LP-BM5 replication. Additionally, semen and blood exosomes had no effect on replication of herpes simplex virus; types 1 and 2 (HSV1 and HSV2). Mechanistic studies indicate that semen exosomes exert a post-entry block on HIV-1 replication by orchestrating deleterious effects on particle-associated reverse transcriptase activity and infectivity.
Conclusions
These illuminating findings i) improve our knowledge of the cargo of semen exosomes, ii) reveal that semen exosomes possess anti-retroviral activity, and iii) suggest that semen exosome-mediated inhibition of HIV-1 replication may provide novel opportunities for the development of new therapeutics for HIV-1.
Journal Article
Chronic Pain and Work Conditions of Hotel Housekeepers: A Descriptive Study
Objectives: To estimate the prevalence of musculoskeletal pain of hotel housekeepers (HHs) and to describe the work conditions and perception of health in this occupational group in the Balearic Islands, Spain. Methods: Cross-sectional descriptive study with HHs of the Balearic Islands, performed in primary care. Random sample of HHs who worked during the 2018 season. We collected information on sociodemographic variables, job characteristics, workload, pain, perceived health, and physical activity. After participants signed the informed consent form, we conducted a face-to-face interview in the primary care centre and accessed the participants’ electronic health records. Results: 1043 HHs aged 43.3 ± 10 years and with 10.7 ± 9.1 years worked as HHs were included. 51% (95% CI: 48–54%) reported chronic pain, mainly in the lower back 28.7% (95% CI: 25.9–31.5%), hands/wrists 23.7% (95% CI: 21.1–26.4%), neck 21.6% (95% CI: 19.1–24.3%), shoulders 19.9% (95% CI: 17.4–22.4%), and back 17.8% (95% CI: 15.4–20.2%). Pain was associated with older age, more years worked, more beds made/day and difficulty in pushing the housekeeping cart. More than half HHs reported that they did not incorporate occupational risk prevention measures (ORPMs) into their routine; 17.3% (95% CI: 15.1–19.7%) HHs considered their health as poor or very poor. Perception of health was worse in HHs with chronic pain. Conclusions: A high percentage of HHs of the Balearic Islands reported chronic pain, a low compliance with ORPMs and compared to women of the same sociodemographic profile they perceive a worse health status.
Journal Article
Murine Cytomegalovirus and Human Cytomegalovirus Differ in Pyroptosis Induction in Different Cell Types During Productive Replication
Pyroptosis is a proinflammatory programmed cell death (PCD) that protects the host against invading viruses. We previously reported that pyroptosis plays a prominent role in the pathogenesis of murine cytomegalovirus (MCMV) retinal necrosis using mice with MAIDS as a mouse model for AIDS-related human cytomegalovirus (HCMV) retinal necrosis. Because MCMV and HCMV exhibit species specificity, we sought to determine if pyroptosis induction extends to different cell types of murine or human origin. In vitro studies were therefore performed in which MCMV-infected mouse fibroblasts and mouse macrophages were compared with HCMV-infected human fibroblasts and human ARPE-19 cells for stimulation of caspase-1, gasdermin G (GSDMD), and interleukin (IL)-18 and/or IL-1β transcripts as markers for canonical pyroptosis operation. Whereas MCMV stimulated significant stimulation of pyroptosis-associated transcripts during productive replication of mouse fibroblasts and mouse macrophages, significant stimulation of these transcripts was not detected during HCMV productive replication of human fibroblasts or ARPE-19 cells. Additional studies using UV-inactivated MCMV suggested that virion tegument proteins are not involved in the induction of pyroptosis in MCMV-infected mouse fibroblasts. We conclude that pyroptosis induction during productive replication of MCMV or HCMV is host cell type-dependent and may extend to species specificity, although virus-encoded PCD suppressors must be considered.
Journal Article
The ‘Means Available to Relieve Suffering’: Translating Medical Assistance in Dying Safeguards in Canadian Policy and Practice
In Canada in 2021, people with non-life-limiting health conditions and disabilities became eligible for medical assistance in dying (MAiD). New legislative safeguards include a ninety-day assessment period and a requirement that health professionals engage with the person requesting MAiD about ‘means available to relieve their suffering’ (MARS). Government communications about the MARS safeguards emphasise distinct policy objectives, that we illustrate by analysing two texts. We then report on an ongoing study with health professionals involved in MAiD. In interviews, participants described supporting patients to imagine possibilities for feeling differently, creatively devising interventions, and actively connecting patients with (and in some cases bringing about) services and resources. Drawing on literature on front-line policy making we show how discourses of expert communication, care, and advocacy animate a specific translation of the MARS safeguards, one that recognises social and relational as well as deliberative autonomy, and reflects a range of MAiD policy goals.
Journal Article