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Humanity has become a dominant force in shaping the face of Earth 1 – 9 . An emerging question is how the overall material output of human activities compares to the overall natural biomass. Here we quantify the human-made mass, referred to as ‘anthropogenic mass’, and compare it to the overall living biomass on Earth, which currently equals approximately 1.1 teratonnes 10 , 11 . We find that Earth is exactly at the crossover point; in the year 2020 (± 6), the anthropogenic mass, which has recently doubled roughly every 20 years, will surpass all global living biomass. On average, for each person on the globe, anthropogenic mass equal to more than his or her bodyweight is produced every week. This quantification of the human enterprise gives a mass-based quantitative and symbolic characterization of the human-induced epoch of the Anthropocene. Estimates of global total biomass (the mass of all living things) and anthopogenic mass (the mass embedded in inanimate objects made by humans) over time show that we are roughly at the timepoint when anthropogenic mass exceeds total biomass.

In the modern economy, international value chains—production, use, and disposal of goods—have global environmental impacts. Life Cycle Assessment (LCA) aims to track these impacts and assess them from a systems perspective, identifying strategies for improvement without burden shifting. We review recent developments in LCA, including existing and emerging applications aimed at supporting environmentally informed decisions in policy-making, product development and procurement, and consumer choices. LCA constitutes a viable screening tool that can pinpoint environmental hotspots in complex value chains, but we also caution that completeness in scope comes at the price of simplifications and uncertainties. Future advances of LCA in enhancing regional detail and accuracy as well as broadening the assessment to economic and social aspects will make it more relevant for producers and consumers alike.

Recent advances in the science and technology of global supply chain management offer near–real-time demand-response systems for decision-makers across production networks. Technology is helping propel \"fast fashion\" and \"lean manufacturing,\" so that companies are better able to deliver products consumers want most. Yet companies know much less about the environmental and social impacts of their production networks. The failure to measure and manage these impacts can be explained in part by limitations in the science of sustainability measurement, as well as by weaknesses in systems to translate data into information that can be used by decision-makers inside corporations and government agencies. There also remain continued disincentives for firms to measure and pay the full costs of their supply chain impacts. I discuss the current state of monitoring, measuring, and analyzing information related to supply chain sustainability, as well as progress that has been made in translating this information into systems to advance more sustainable practices by corporations and consumers. Better data, decision-support tools, and incentives will be needed to move from simply managing supply chains for costs, compliance, and risk reduction to predicting and preventing unsustainable practices.

Fifty enthusiasts who gathered last week at CERN, Europe's particle-physics laboratory near Geneva, Switzerland, are hoping to remedy researchers' lack of awareness about open science hardware. At the first conference dedicated to the field, they met to compare creations - and to thrash out a road map to promote the widespread manufacturing and sharing of labware.

A commercial port town on the East China Sea, a bustling manufacturing city in Ireland, and a scenic city on the Mediterranean coast—what ties together these regions and their people, economies, and environments? They could be part of a product's supply chain. Because the global economy rests on the maintenance of such chains, there needs to be a shift in perspective, from considering supply chains as isolated parts to optimizing them as sustainable wholes. The good news is that academia, industry, government, and civil society organizations recognize this and are seeking ways to work together to achieve sustainability across supply chains.

In the emergency management relevant to chemical contingency spills, efficiency emergency rescue can be deeply influenced by a reasonable assignment of the available emergency materials to the related risk sources. In this study, an emergency material scheduling model (EMSM) with time-effective and cost-effective objectives is developed to coordinate both allocation and scheduling of the emergency materials. Meanwhile, an improved genetic algorithm (IGA) which includes a revision operation for EMSM is proposed to identify the emergency material scheduling schemes. Then, scenario analysis is used to evaluate optimal emergency rescue scheme under different emergency pollution conditions associated with different threat degrees based on analytic hierarchy process (AHP) method. The whole framework is then applied to a computational experiment based on south-to-north water transfer project in China. The results demonstrate that the developed method not only could guarantee the implementation of the emergency rescue to satisfy the requirements of chemical contingency spills but also help decision makers identify appropriate emergency material scheduling schemes in a balance between time-effective and cost-effective objectives.

From concrete to plastics, the megatonnes of stuff in the built environment are mostly manufactured and used with little thought for waste and pollution. Radical moves are afoot to refashion the urban fabric.

The successful commercialization of regenerative medicine products provides a unique challenge to the manufacturer owing to a lack of suitable investment/business models and a constantly evolving regulatory framework. The resultant slow translation of scientific discovery into safe and clinically efficacious therapies is preventing many potential products from reaching the market. This is despite of the need for new therapies that may reduce the burden on the world's healthcare systems and address the desperate need for replacement tissues and organs. The collaborative Engineering and Physical Sciences Research Council (EPSRC)-funded remedi project was devised to take a holistic but manufacturing-led approach to the challenge of translational regenerative medicine in the UK. Through strategic collaborations and discussions with industry and other academic partners, many of the positive and negative issues surrounding business and regulatory success have been documented to provide a remedi-led perspective on the management of risk in business and the elucidation of the regulatory pathways, and how the two are inherently linked. This article represents the findings from these discussions with key stakeholders and the research into best business and regulatory practices.

It is indisputable that modern life is enabled by the use of materials in its technologies. Those technologies do many things very well, largely because each material is used for purposes to which it is exquisitely fitted. The result over time has been a steady increase in product performance. We show that this materials complexity has markedly increased in the past half-century and that elemental life cycle analyses characterize rates of recycling and loss. A further concern is that of possible scarcity of some of the elements as their use increases. Should materials availability constraints occur, the use of substitute materials comes to mind. We studied substitution potential by generating a comprehensive summary of potential substitutes for 62 different metals in all their major uses and of the performance of the substitutes in those applications. As we show herein, for a dozen different metals, the potential substitutes for their major uses are either inadequate or appear not to exist at all. Further, for not 1 of the 62 metals are exemplary substitutes available for all major uses. This situation largely decouples materials substitution from price, thereby forcing material design changes to be primarily transformative rather than incremental. As wealth and population increase worldwide in the next few decades, scientists will be increasingly challenged to maintain and improve product utility by designing new and better materials, but doing so under potential constraints in resource availability. Significance Modern life is enabled by the use of materials in its technologies. Over time, these technologies have used a larger and more diverse array of materials. Elemental life cycle analyses yield an understanding of these materials, and a definite concern that arises is that of possible scarcity of some of the elements as their use increases. We studied substitution potential for 62 different metals in their major uses. For a dozen different metals, the potential substitutes for their major uses are either inadequate or appear not to exist at all. Further, for not 1 of the 62 metals are exemplary substitutes available for all major uses.

In this paper, we examine prospects for the manufacture of patient-specific biomedical implants replacing hard tissues (bone), particularly knee and hip stems and large bone (femoral) intramedullary rods, using additive manufacturing (AM) by electron beam melting (EBM). Of particular interest is the fabrication of complex functional (biocompatible) mesh arrays. Mesh elements or unit cells can be divided into different regions in order to use different cell designs in different areas of the component to produce various or continually varying (functionally graded) mesh densities. Numerous design elements have been used to fabricate prototypes by AM using EBM of Ti-6Al-4V powders, where the densities have been compared with the elastic (Young) moduli determined by resonant frequency and damping analysis. Density optimization at the boneimplant interface can allow for bone ingrowth and cementless implant components. Computerized tomography (CT) scans of metal (aluminium alloy) foam have also allowed for the building of Ti-6Al-4V foams by embedding the digital-layered scans in computer-aided design or software models for EBM. Variations in mesh complexity and especially strut (or truss) dimensions alter the cooling and solidification rate, which alters the -phase (hexagonal close-packed) microstructure by creating mixtures of / (martensite) observed by optical and electron metallography. Microindentation hardness measurements are characteristic of these microstructures and microstructure mixtures (/) and sizes.