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"Materia medica, Vegetable Encyclopedias."
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Encyclopedia of herbal medicine
With 550 key herbs and their uses as natural remedies for nearly 200 common ailments, this is the definitive home reference to healing with the world's oldest form of medicine. From ginger to lavender and thyme to dandelion, learn about the chemistry of plants and how and why they work as medicines within the body.
Book
Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Picrorhizae Rhizoma Extract
This study sought to explore the anticancer mechanism of Picrorhizae Rhizoma (PR) extract based on network pharmacology and molecular docking. The potential chemicals of PR were screened through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and relevant literatures. Corresponding targets of active ingredients were found with the help of the UniProtKB database, and therapeutic targets for cancer action were screened with the help of the GeneCards database. We used Cytoscape software to construct the compound-target-pathway network of PR extract. We utilized the STRING database to obtain the protein-protein interaction (PPI) network. We used DAVID database combining Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, molecular docking was employed for initial efficacy checking. We have identified 16 potential active components of PR through screening, involving 112 disease action targets. Utilizing the GeneCards database, 112 intersecting targets between PR extract and cancer were found, which mainly exerts anticancer effects by regulating tumor necrosis factor (TNF), recombinant caspase 3 (CASP3), c-Jun NH2-terminal kinase (JNK)/JUN, epidermal growth factor receptor (EGFR), and estrogen receptor-1 (ESR1) with some other target genes and pathways associated with cancer. The major anticancer species are prostate cancer, colorectal cancer, small cell lung cancer, etc. In the molecular docking study, herbactin had a strong affinity for TNF. Based on network pharmacology and molecular docking studies, PR and their compounds have demonstrated potential anticancer activities against several key targets. Our preliminary findings provide a strong foundation for further experiments with PR constituents.
Journal Article
Encyclopedia of herbal medicine
Provides coverage of hundreds of conditions and their remedies, including their sources and symptoms.
Book
Chemical Components of Aqueous Extracts of Melia azedarach Fruits and Their Effects on The Transcriptome of Staphylococcus aureus
is the causative agent of numerous and varied clinical infections. Crude aqueous extracts of
fruits inhibit the planktonic growth and initial biofilm formation of
in a dose-dependent manner. Moreover, the biofilm topologies became sparse and decreased as the concentration of the aqueous extracts increased. RNA-Seq analyses revealed 532 differentially expressed genes (DEGs) after
exposure to 0.25 g/ml extracts; 319 of them were upregulated, and 213 were downregulated. The majority of DEGs were categorized into abundant sub-groups in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, untargeted UHPLC-MS/MS analyses of the aqueous extracts of
fruits demonstrated a highly complex profile in positive and negative electrospray ionization modes. The extracts primarily consisted of lipids and lipid-like molecules, organic acids and their derivatives, phenylpropanoids, polyketides, organoheterocyclic compounds, and benzenoids annotated by abundant lipid maps and KEGG pathways. Overall, this study provides evidences that the aqueous extracts of
fruits can control
infections and sought to understand the mode of action of these extracts on
Journal Article
Encyclopedia of traditional Chinese medicines : molecular structures, pharmacological activities, natural sources and applications
This set of six volumes provides a systematic and standardized description for 23,033 chemical components isolated from 6734 medicinal plants. It provides a chemical structure with stereo-chemistry bonds for each chemical component.
eBook
Compendia of world's medicinal flora
Alternative systems of medicine (Ayurveda, Siddha, Homoepathy, Traditional Chinese Medicine and Western Medcila Herbalism) utilizes medicinal plants for formulations. The present work is aimed at documentation of chemical composition, medicinal use and modern investigative work on medicinal plants. As the name of the title suggests, the work includ
eBook