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Advanced materials technologies to unravel mechanobiological phenomena
Advanced material technologies are being developed to precisely manipulate mechanical cues independently of biochemical signals, enabling the investigation of mechanobiological phenomena and their underlying mechanisms.Biomaterial-based mechanomodulatory platforms have emerged as potent tools, finely tuning cellular behaviors by adjusting mechanical properties and effectively acting as synthetic extracellular matrices (ECMs).Bottom-up platforms mimic ECM mechanics, including viscoelasticity, fibrous structure, and stiffness gradients. They offer insights into cellular mechanoresponses and behavior changes driven by cell-mediated matrix remodeling.Dynamic platforms using light, magnetic fields, and microfluidics customize mechanical modulation to facilitate spatiotemporal analysis of cell–ECM dynamics for enhanced mechanobiological studies.
Advancements in materials-driven mechanobiology have yielded significant progress. Mechanobiology explores how cellular and tissue mechanics impact development, physiology, and disease, where extracellular matrix (ECM) dynamically interacts with cells. Biomaterial-based platforms emulate synthetic ECMs, offering precise control over cellular behaviors by adjusting mechanical properties. Recent technological advances enable in vitro models replicating active mechanical stimuli in vivo. These models manipulate cellular mechanics even at a subcellular level. In this review we discuss recent material-based mechanomodulatory studies in mechanobiology. We highlight the endeavors to mimic the dynamic properties of native ECM during pathophysiological processes like cellular homeostasis, lineage specification, development, aging, and disease progression. These insights may inform the design of accurate in vitro mechanomodulatory platforms that replicate ECM mechanics.
Advancements in materials-driven mechanobiology have yielded significant progress. Mechanobiology explores how cellular and tissue mechanics impact development, physiology, and disease, where extracellular matrix (ECM) dynamically interacts with cells. Biomaterial-based platforms emulate synthetic ECMs, offering precise control over cellular behaviors by adjusting mechanical properties. Recent technological advances enable in vitro models replicating active mechanical stimuli in vivo. These models manipulate cellular mechanics even at a subcellular level. In this review we discuss recent material-based mechanomodulatory studies in mechanobiology. We highlight the endeavors to mimic the dynamic properties of native ECM during pathophysiological processes like cellular homeostasis, lineage specification, development, aging, and disease progression. These insights may inform the design of accurate in vitro mechanomodulatory platforms that replicate ECM mechanics.
Journal Article
Composites science, technology, and engineering
\"Understand critical principles of composites, such as design of durable structures, choice of fibre, matrix, manufacturing process and mechanics with this interdisciplinary text. Features up-to-date coverage of hybrids of fibres and particles and explanation of failure criteria. Includes a comprehensive discussion on choice of fibres, matrices, manufacturing technology and micromechanics for durable composite structures. Provides the structure and properties of reinforcing fibres, particulates and matrices together with a discussion of fracture mechanics. This is an essential guide for scientists and engineers wishing to discover the benefits of composite materials for designing strong and durable structures\"-- Provided by publisher.
Book
Nanoanalytics
Nanoanalytics is a novel branch of analytical chemistry which explores applications of nanotechnologies in chemical analysis.This comprehensive publication gives an overview of the analytical techniques used to study nanoobjects and nanoparticles as well as the application of nanomaterials themselves in the development of new methods of analysis.
eBook
Environmental degradation of advanced and traditional engineering materials
\"From metals and polymers to ceramics, natural materials, and composites, this book covers the environmental impacts on a broad range of materials used for the engineering of infrastructure, buildings, machines, and components all of which experience some form of degradation. The text discusses fundamental degradation processes and presents examples of degradation under various environmental conditions. It gives the fundamental principles for each class of material, followed by detailed characteristics of degradation for specific alloys of compositions, guidelines on how to protect against degradation, and a description of testing procedures\"-- Provided by publisher.
Book
Phosphorus(III) ligands in homogeneous catalysis
\"Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals.This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis.Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation.Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands.Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice.Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry\"--
eBook
Making the modern world : materials and dematerialization
\"How much further should the affluent world push its material consumption? Does relative dematerialization lead to absolute decline in demand for materials? These and many other questions are discussed and answered in Making the Modern World: Materials and Dematerialization.Over the course of time, the modern world has become dependent on unprecedented flows of materials. Now even the most efficient production processes and the highest practical rates of recycling may not be enough to result in dematerialization rates that would be high enough to negate the rising demand for materials generated by continuing population growth and rising standards of living. This book explores the costs of this dependence and the potential for substantial dematerialization of modern economies. Making the Modern World: Materials and Dematerialization considers the principal materials used throughout history, from wood and stone, through to metals, alloys, plastics, and silicon, describing their extraction and production as well as their dominant applications. The evolving productivities of material extraction, processing, synthesis, finishing, and distribution, and the energy costs and environmental impact of rising material consumption are examined in detail. The book concludes with an outlook for the future, discussing the prospects for dematerialization and potential constraints on materials.This interdisciplinary text will provide useful perspectives for readers with backgrounds including resource economics, environmental studies, energy analysis, mineral geology, industrial organization, manufacturing, and material science\"-- Provided by publisher.
Book
Dictionary of Ceramics
This updated edition of Dr A E Dodd's classic ceramics dictionary contains over 2000 new terms, including terminology covering new developments in engineering ceramics, electroceramics, whiteware processes and environmental legislation. The coverage of glass, vitreous enamel and the cement industries has been widened and relevant areas of basic science i.e. crystal structure, fracture mechanics and sintering, have been included.
eBook
Progress in Modern Marine Biomaterials Research
The growing demand for new, sophisticated, multifunctional materials has brought natural structural composites into focus, since they underwent a substantial optimization during long evolutionary selection pressure and adaptation processes. Marine biological materials are the most important sources of both inspiration for biomimetics and of raw materials for practical applications in technology and biomedicine. The use of marine natural products as multifunctional biomaterials is currently undergoing a renaissance in the modern materials science. The diversity of marine biomaterials, their forms and fields of application are highlighted in this review. We will discuss the challenges, solutions, and future directions of modern marine biomaterialogy using a thorough analysis of scientific sources over the past ten years.
Journal Article