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Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Adverse health effects from exposure to lead are now recognized to be among industrialized society's most important health problems. This report, prepared by the National Research Council's Committee on Measuring Lead Exposure in Critical Populations, concurs with new findings issued by the Centers for Disease Control which state that lead concentrations above 10 micrograms per deciliter of whole blood in pregnant women, fetuses, and young children may be associated with toxic effects. Chapter 1 serves as an introduction and provides historical background on lead exposure concerns. Chapters 2 and 3 summarize the toxicity of lead and sources of exposure to lead for sensitive populations. Chapter 4 deals with lead in blood and other physiological media and describes the monitoring of biological markers that indicate exposure, markers of early toxic effects, and markers of susceptibility. Chapter 5 assesses techniques for quantitative measurement of the biological markers of exposure and effect, while chapter 6 presents the committee's conclusions and recommendations to improve the monitoring of lead in sensitive populations. Contains 74 pages of references. (MDM)

Bisphenol-A (BPA) is a synthetic chemical ubiquitous in the environment and listed as an endocrine disruptor. It has the tendency of migrating into food stored in materials containing it. This study, therefore, determines the concentrations of BPA in foods commonly consumed in Southwest Nigeria by the adult population and also estimates the risk associated with human exposure. Eight different food categories were selected for this study. Standard QuEChERS protocol was used for sample extraction and analysed using gas chromatography-mass spectrometry (GC-MS). Vegetable oil had the highest BPA concentration (28.4 ng/g). This was followed by aquatic canned fish (26.3 ng/g), canned beef (21.3 ng/g) and crayfish (17.5 ng/g). These concentrations were below the 600 ng/g limit of the European Commission for BPA in foods. Bisphenol-A was not detected in raw beef, chicken, cheese, apple, tomatoes, beans and rice; and chicken eggs. The adult population had an average dietary intake of 30.4 ng/kg bw/day. There is no likely occurrence of harmful health effects of BPA in the selected foods with respect to the current concentrations found therein. However, routine monitoring is recommended to prevent human exposure to BPA.

The main objective of the present study is to evaluate the hydrogeochemical characteristics of groundwater and its suitability for drinking water supply in Kangayam taluk, Tirupur district, Tamil Nadu, India. To achieve this objective, seventy-eight groundwater samples were collected from the wells spread over the study area during December 2016. The collected groundwater samples were tested in the laboratory for various hydrogeochemical parameters such as hydrogen ion concentration (pH), electrical conductivity, total dissolved solids, total hardness, calcium, magnesium, sodium, potassium, chloride, bicarbonate, carbonate, nitrate, sulphate and fluoride. The analytical results were compared with WHO drinking water standards to assess the suitability of groundwater for drinking purposes. To understand the spatial variation of hydrogeochemical parameters over the study area, choropleth (zonation) maps were prepared using geographical information system (GIS). Overall groundwater quality zones were demarcated by overlaying and integrating all the spatial plots using GIS. Three groundwater quality zones such as (1) most desirable, (2) maximum allowable and (3) not permissible were demarcated based on the limits prescribed by the WHO for drinking purposes. This study indicates that 49% of the study area does not possess potable groundwater. About 21% of the area represents “most desirable” category, and the remaining 30% area represents “maximum allowable” category for drinking purposes. The Piper’s trilinear diagram indicates that groundwater of this region is Mixed CaMgCl type. As the groundwater quality is poor nearly 49% of the total area, it is necessary to go for treatment before drinking water supply. It is also essential to recharge the aquifer artificially to improve the quantity and quality of groundwater.

A survey on 120 cereal samples (barley, maize, rice and wheat) from Algerian markets has been carried out to evaluate the presence of 15 mycotoxins (ochratoxin A, deoxynivalenol, fumonisin B1 and B2, T-2 and HT-2 toxins, zearalenone, fusarenon X, citrinin, sterigmatocystin, enniatins A, A1, B and B1, and beauvericin). With this purpose, a QuEChERS-based extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) were used. Analytical results showed that 78 cereal samples (65%) were contaminated with at least one toxin, while 50% were contaminated with three to nine mycotoxins. T-2 toxin, citrinin, beauvericin and deoxynivalenol were the most commonly found mycotoxins (frequency of 50%, 41.6%, 40.8% and 33.3%, respectively). Fumonisins (B1 + B2), enniatins B and B1, deoxynivalenol and zearalenone registered high concentrations (289–48878 µg/kg, 1.2–5288 µg/kg, 15–4569 µg/kg, 48–2055 µg/kg and 10.4–579 µg/kg, respectively). Furthermore, concentrations higher than those allowed by the European Union (EU) were observed in 21, 8 and 1 samples for fumonisins, zearalenone and deoxinivalenol, respectively. As a conclusion, the high levels of fumonisins (B1 + B2) in maize and deoxynivalenol, zearalenone and HT-2 + T-2 toxins in wheat, represent a health risk for the average adult consumer in Algeria. These results pointed out the necessity of a consistent control and the definition of maximum allowed levels for mycotoxins in Algerian foodstuffs.

More than a decade ago, prospective epidemiologic studies showed that mortality was increased among people living in communities with elevated concentrations of fine particulate air pollution. 1 , 2 Subsequent research has shown that particulate air pollution is statistically and mechanistically linked to increased cardiovascular disease. 3 New data are beginning to shed light on which persons are at heightened risk. In this issue of the Journal, Miller et al. 4 report on data from the Women's Health Initiative (WHI) observational study, which greatly expands our understanding of how fine particulate pollution affects health. Earlier long-term prospective cohort studies showed an association between levels . . .

We focus on the recent evidence that elucidates our understanding about the effects of cadmium (Cd) on human health and their prevention. Recently, there has been substantial progress in the exploration of the shape of the Cd concentration-response function on osteoporosis and mortality. Environmental exposure to Cd increases total mortality in a continuous fashion without evidence of a threshold, independently of kidney function and other classical factors associated with mortality including age, gender, smoking and social economic status. Pooled hazard rates of two recent environmental population based cohort studies revealed that for each doubling of urinary Cd concentration, the relative risk for mortality increases with 17% (95% CI 4.2-33.1%; P < 0.0001). Tubular kidney damage starts at urinary Cd concentrations ranging between 0.5 and 2 μg urinary Cd/g creatinine, and recent studies focusing on bone effects show increased risk of osteoporosis even at urinary Cd below 1 μg Cd/g creatinine. The non-smoking adult population has urinary Cd concentrations close to or higher than 0.5 μg Cd/g creatinine. To diminish the transfer of Cd from soil to plants for human consumption, the bioavailability of soil Cd for the plants should be reduced (external bioavailability) by maintaining agricultural and garden soils pH close to neutral (pH-H₂O of 7.5; pH-KCL of 6.5). Reducing the systemic bioavailability of intestinal Cd can be best achieved by preserving a balanced iron status. The latter might especially be relevant in groups with a lower intake of iron, such as vegetarians, and women in reproductive phase of life. In exposed populations, house dust loaded with Cd is an additional relevant exposure route. In view of the insidious etiology of health effects associated with low dose exposure to Cd and the current European Cd intake which is close to the tolerable weekly intake, one should not underestimate the importance of the recent epidemiological evidence on Cd toxicity as to its medical and public health implications.

Agricultural contamination with pesticides and antibiotics is a challenging problem that needs to be fully addressed. Bee products, such as honey, are widely consumed as food and medicine and their contamination may carry serious health hazards. Honey and other bee products are polluted by pesticides, heavy metals, bacteria and radioactive materials. Pesticide residues cause genetic mutations and cellular degradation and presence of antibiotics might increase resistant human or animal's pathogens. Many cases of infant botulisms have been attributed to contaminated honey. Honey may be very toxic when produced from certain plants. Ingestion of honey without knowing its source and safety might be problematic. Honey should be labeled to explore its origin, composition, and clear statement that it is free from contaminants. Honey that is not subjected for analysis and sterilization should not be used in infants, and should not be applied to wounds or used for medicinal purposes. This article reviews the extent and health impact of honey contamination and stresses on the introduction of a strict monitoring system and validation of acceptable minimal concentrations of pollutants or identifying maximum residue limits for bee products, in particular, honey.

BACKGROUND:Respiratory exposure to silica is associated with the risk of death due to malignant and non-malignant disease. 2.3 million U.S. workers are exposed to silica. Occupational exposure limits for silica are derived from a number of lines of evidence, including observational studies. Observational studies may be subject to healthy worker survivor bias, which could result in underestimates of silica’s impact on worker mortality and, in turn, bias risk estimates for occupational exposure limits. METHODS:Using data on 65,999 workers pooled across multiple industries, we estimate the impacts of several hypothetical occupational exposure limits on silica exposure on lung cancer and all-cause mortality. We use the parametric g-formula, which can account for healthy worker survivor bias. RESULTS:Assuming we could eliminate occupational exposure, we estimate that there would be 20.7 fewer deaths per 1,000 workers in our pooled study by age 80 (95% confidence interval14.5, 26.8), including 3.91 fewer deaths due to lung cancer (95%CI1.53, 6.30). Less restrictive interventions demonstrated smaller, but still substantial risk reductions. CONCLUSIONS:Our results suggest that occupational exposure limits for silica can be further strengthened to reduce silica-associated mortality and illustrate how current risk analysis for occupational limits can be improved.