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Geospatial health data are essential to inform public health and policy. These data can be used to quantify disease burden, understand geographic and temporal patterns, identify risk factors, and measure inequalities. Geospatial Health Data: Modeling and Visualization with R-INLA and Shiny describes spatial and spatio-temporal statistical methods and visualization techniques to analyze georeferenced health data in R. The book covers the following topics: Manipulating and transforming point, areal, and raster data, Bayesian hierarchical models for disease mapping using areal and geostatistical data, Fitting and interpreting spatial and spatio-temporal models with the integrated nested Laplace approximation (INLA) and the stochastic partial differential equation (SPDE) approaches, Creating interactive and static visualizations such as disease maps and time plots, Reproducible R Markdown reports, interactive dashboards, and Shiny web applications that facilitate the communication of insights to collaborators and policymakers. The book features fully reproducible examples of several disease and environmental applications using real-world data such as malaria in The Gambia, cancer in Scotland and USA, and air pollution in Spain. Examples in the book focus on health applications, but the approaches covered are also applicable to other fields that use georeferenced data including epidemiology, ecology, demography or criminology. The book provides clear descriptions of the R code for data importing, manipulation, modelling, and visualization, as well as the interpretation of the results. This ensures contents are fully reproducible and accessible for students, researchers and practitioners. I Geospatial health data and INLA 1. Geospatial health Geospatial health data Disease mapping Communication of results 2. Spatial data and R packages for mapping Types of spatial data Areal data Geostatistical data Point patterns Coordinate Reference Systems (CRS) Geographic coordinate systems Projected coordinate systems Setting Coordinate Reference Systems in R Shapefiles Making maps with R ggplot2 leaflet mapview tmap 3. Bayesian inference and INLA Bayesian inference Integrated Nested Laplace Approximations (INLA) 4. The R-INLA package Linear predictor The inla() function Priors specification Example Data Model Results Control variables to compute approximations II Modeling and visualization 5. Areal data Spatial neighborhood matrices Standardized Incidence Ratio (SIR) Spatial small area disease risk estimation Spatial modeling of lung cancer in Pennsylvania Spatio-temporal small area disease risk estimation Issues with areal data 6. Spatial modeling of areal data. Lip cancer in Scotland Data and map Data preparation Adding data to map Mapping SIRs Modeling Model Neighborhood matrix Inference using INLA Results Mapping relative risks Exceedance probabilities 7. Spatio-temporal modeling of areal data. Lung cancer in Ohio Data and map Data preparation Observed cases Expected cases SIRs Adding data to map Mapping SIRs Time plots of SIRs Modeling Model Neighborhood matrix Inference using INLA Mapping relative risks 8. Geostatistical data Gaussian random fields Stochastic Partial Differential Equation approach (SPDE) Spatial modeling of rainfall in Paraná, Brazil Model Mesh construction Building the SPDE model on the mesh Index set Projection matrix Prediction data Stack with data for estimation and prediction Model formula inla() call Results Projecting the spatial field Disease mapping with geostatistical data 9. Spatial modeling of geostatistical data. Malaria in The Gambia Data Data preparation Prevalence Transforming coordinates Mapping prevalence Environmental covariates Modeling Model Mesh construction Building the SPDE model on the mesh Index set Projection matrix Prediction data Stack with data for estimation and prediction Model formula inla() call Mapping malaria prevalence Mapping exceedance probabilities 10. Spatio-temporal modeling of geostatistical data. Air pollution in Spain Map Data Modeling Model Mesh construction Building the SPDE model on the mesh Index set Projection matrix Prediction data Stack with data for estimation and prediction Model formula inla() call Results Mapping air pollution predictions III Communication of results 11. Introduction to R Markdown R Markdown YAML Markdown syntax R code chunks Figures Tables Example 12. Building a dashboard to visualize spatial data with flexdashboard The R package flexdashboard R Markdown Layout Dashboard components A dashboard to visualize global air pollution Data Table using DT Map using leaflet Histogram using ggplot2 R Markdown structure. YAML header and layout R code to obtain the data and create the visualizations 13. Introduction to Shiny Examples of Shiny apps Structure of a Shiny app Inputs Outputs Inputs, outputs and reactivity Examples of Shiny apps Example 1 Example 2 HTML Content Layouts Sharing Shiny apps 14. Interactive dashboards with flexdashboard and Shiny An interactive dashboard to visualize global air pollution 15. Building a Shiny app to upload and visualize spatio-temporal data Shiny Setup Structure of app.R Layout HTML content Read data Adding outputs Table using DT Time plot using dygraphs Map using leaflet Adding reactivity Reactivity in dygraphs Reactivity in leaflet Uploading data Inputs in ui to upload a CSV file and a shapefile Uploading CSV file in server() Uploading shapefile in server() Accessing the data and the map Handling missing inputs Requiring input files to be available using req() Checking data are uploaded before creating the map Conclusion 16. Disease surveillance with SpatialEpiApp Installation Use of SpatialEpiApp ‘Inputs’ page ‘Analysis’ page ‘Help’ page Appendix A R installation and packages used in the book A.1 Installing R and RStudio A.2 Installing R packages A.3 Packages used in the book \" The stress is on practical usage of INLA modelling in a spatial context and hence the author shows the full code for several carefully selected examples. Essentially all the steps from the beginning (necessary data manipulation and preparation) via INLA analysis itself (often in several alternatives) to the results (plots and maps) are explained carefully and commented. This is very useful for anybody who wants to start with the powerful INLA but did not dare to go through the very powerful but notalways- fully-documented environment.\" ~Marek Brabec, ISCB News Paula Moraga is a Lecturer in the Department of Mathematical Sciences at the University of Bath. She received her Master’s in Biostatistics from Harvard University and her Ph.D. in Statistics from the University of Valencia. Dr. Moraga develops innovative statistical methods and open-source software for disease surveillance including R packages for spatio-temporal modeling, detection of clusters, and travel-related spread of disease. Her work has directly informed strategic policy in reducing the burden of diseases such as malaria and cancer in several countries.

Background As of 13 July 2020, 12.9 million COVID-19 cases have been reported worldwide. Prior studies have demonstrated that local socioeconomic and built environment characteristics may significantly contribute to viral transmission and incidence rates, thereby accounting for some of the spatial variation observed. Due to uncertainties, non-linearities, and multiple interaction effects observed in the associations between COVID-19 incidence and socioeconomic, infrastructural, and built environment characteristics, we present a structured multimethod approach for analysing cross-sectional incidence data within in an Exploratory Spatial Data Analysis (ESDA) framework at the NUTS3 (county) scale. Methods By sequentially conducting a geospatial analysis, an heuristic geographical interpretation, a Bayesian machine learning analysis, and parameterising a Generalised Additive Model (GAM), we assessed associations between incidence rates and 368 independent variables describing geographical patterns, socioeconomic risk factors, infrastructure, and features of the build environment. A spatial trend analysis and Local Indicators of Spatial Autocorrelation were used to characterise the geography of age-adjusted COVID-19 incidence rates across Germany, followed by iterative modelling using Bayesian Additive Regression Trees (BART) to identify and measure candidate explanatory variables. Partial dependence plots were derived to quantify and contextualise BART model results, followed by the parameterisation of a GAM to assess correlations. Results A strong south-to-north gradient of COVID-19 incidence was identified, facilitating an empirical classification of the study area into two epidemic subregions. All preliminary and final models indicated that location, densities of the built environment, and socioeconomic variables were important predictors of incidence rates in Germany. The top ten predictor variables’ partial dependence exhibited multiple non-linearities in the relationships between key predictor variables and COVID-19 incidence rates. The BART, partial dependence, and GAM results indicate that the strongest predictors of COVID-19 incidence at the county scale were related to community interconnectedness, geographical location, transportation infrastructure, and labour market structure. Conclusions The multimethod ESDA approach provided unique insights into spatial and aspatial non-stationarities of COVID-19 incidence in Germany. BART and GAM modelling indicated that geographical configuration, built environment densities, socioeconomic characteristics, and infrastructure all exhibit associations with COVID-19 incidence in Germany when assessed at the county scale. The results suggest that measures to implement social distancing and reduce unnecessary travel may be important methods for reducing contagion, and the authors call for further research to investigate the observed associations to inform prevention and control policy.

\"Authoritative and comprehensive, this is the leading text and professional resource on using geographic information systems (GIS) to analyze and address public health problems. Basic GIS concepts and tools are explained, including ways to access and manage spatial databases. The book presents state-of-the-art methods for mapping and analyzing data on population, health events, risk factors, and health services, and for incorporating geographical knowledge into planning and policy. Numerous maps, diagrams, and real-world applications are featured. The companion Web page provides lab exercises with data that can be downloaded for individual or course use\"-- Provided by publisher.

Context Unoccupied aerial systems/vehicles (UAS/UAV, a.k.a. drones) have become an increasingly popular tool for ecological research. But much of the recent research is concerned with developing mapping and detection approaches, with few studies attempting to link UAS data to ecosystem processes and function. Landscape ecologists have long used high resolution imagery and spatial analyses to address ecological questions and are therefore uniquely positioned to advance UAS research for ecological applications. Objectives The review objectives are to: (1) provide background on how UAS are used in landscape ecological studies, (2) identify major advancements and research gaps, and (3) discuss ways to better facilitate the use of UAS in landscape ecology research. Methods We conducted a systematic review based on PRISMA guidelines using key search terms that are unique to landscape ecology research. We reviewed only papers that applied UAS data to investigate questions about ecological patterns, processes, or function. Results We summarize metadata from 161 papers that fit our review criteria. We highlight and discuss major research themes and applications, sensors and data collection techniques, image processing, feature extraction and spatial analysis, image fusion and satellite scaling, and open data and software. Conclusion We observed a diversity of UAS methods, applications, and creative spatial modeling and analysis approaches. Key aspects of UAS research in landscape ecology include modeling wildlife micro-habitats, scaling of ecosystem functions, landscape and geomorphic change detection, integrating UAS with historical aerial and satellite imagery, and novel applications of spatial statistics.

•Public sentiment on COVID-19 vaccines varied significantly over time and geography.•Sentiment analysis is an effective way to gain insight into the public's sentiment towards the covid-19 vaccine.•Twitter has become an important platform for gathering public opinion. To identify themes and temporal trends in the sentiment of COVID-19 vaccine-related tweets and to explore variations in sentiment at world national and United States state levels. We collected English-language tweets related to COVID-19 vaccines posted between November 1, 2020, and January 31, 2021. We applied the Valence Aware Dictionary and sEntiment Reasoner tool to calculate the compound score to determine whether the sentiment mentioned in each tweet was positive (compound ≥ 0.05), neutral (-0.05 < compound < 0.05), or negative (compound ≤ -0.05). We applied the latent Dirichlet allocation analysis to extract main topics for tweets with positive and negative sentiment. Then we performed a temporal analysis to identify time trends and a geographic analysis to explore sentiment differences in tweets posted in different locations. Out of a total of 2,678,372 COVID-19 vaccine-related tweets, tweets with positive, neutral, and negative sentiments were 42.8%, 26.9%, and 30.3%, respectively. We identified five themes for positive sentiment tweets (trial results, administration, life, information, and efficacy) and five themes for negative sentiment tweets (trial results, conspiracy, trust, effectiveness, and administration). On November 9, 2020, the sentiment score increased significantly (score = 0.234, p = 0.001), then slowly decreased to a neutral sentiment in late December and was maintained until the end of January. At the country level, tweets posted in Brazil had the lowest sentiment score of −0.002, while tweets posted in the United Arab Emirates had the highest sentiment score of 0.162. The overall average sentiment score for the United States was 0.089, with Washington, DC having the highest sentiment score of 0.144 and Wyoming having the lowest sentiment score of 0.036. Public sentiment on COVID-19 vaccines varied significantly over time and geography. Sentiment analysis can provide timely insights into public sentiment toward the COVID-19 vaccine and guide public health policymakers in designing locally tailored vaccine education programs.

This study aims to evaluate the dialectical relationship between equity and efficiency of health resource allocation and health service utilization in China. We analyzed the inequity of health resource allocation and health service utilization based on concentration index (CI) and Gini coefficient. Data envelopment analysis (DEA) was used to evaluate the inefficiency of resource allocation and service utilization. Factor Analysis (FA) was used to determine input/output indicators. The CI of Health Institutions, Beds in Health Institutions, Health Professionals and Outpatient Visits were -0.116, -0.012, 0.038, and 0.111, respectively. Gini coefficient for the 31 provinces varied between 0.05 and 0.43; out of these 23 (742%) were observed to be technically efficient constituting the \"best practice frontier\". The other 8 (25.8%) provinces were technically inefficient. Health professionals and outpatient services are focused on higher income levels, while the Health Institutions and Beds in Health Institutions were concentrated on lower income levels. In China, a few provinces attained a basic balance in both equity and efficiency in terms of current health resource and service utilization, thus serving as a reference standard for other provinces.

Traditional methods for monitoring influenza are haphazard and lack fine-grained details regarding the spatial and temporal dynamics of outbreaks. Twitter gives researchers and public health officials an opportunity to examine the spread of influenza in real-time and at multiple geographical scales. In this paper, we introduce an improved framework for monitoring influenza outbreaks using the social media platform Twitter. Relying upon techniques from geographic information science (GIS) and data mining, Twitter messages were collected, filtered, and analyzed for the thirty most populated cities in the United States during the 2013-2014 flu season. The results of this procedure are compared with national, regional, and local flu outbreak reports, revealing a statistically significant correlation between the two data sources. The main contribution of this paper is to introduce a comprehensive data mining process that enhances previous attempts to accurately identify tweets related to influenza. Additionally, geographical information systems allow us to target, filter, and normalize Twitter messages.

Field-evolved resistance of pests to transgenic crops continues to emerge but can be delayed by using refuges as part of an integrated pest managent strategy. Transgenic crops have revolutionized insect pest control, but their effectiveness has been reduced by evolution of resistance in pests. We analyzed global monitoring data reported during the first two decades of transgenic crops, with each case representing the responses of one pest species in one country to one insecticidal protein from Bacillus thuringiensis (Bt). The cases of pest resistance to Bt crystalline (Cry) proteins produced by transgenic crops increased from 3 in 2005 to 16 in 2016. By contrast, in 17 other cases there was no decrease in pest susceptibility to Bt crops, including the recently introduced transgenic corn that produces a Bt vegetative insecticidal protein (Vip). Recessive inheritance of pest resistance has favored sustained susceptibility, but even when inheritance is not recessive, abundant refuges of non-Bt host plants have substantially delayed resistance. These insights may inform resistance management strategies to increase the durability of current and future transgenic crops.