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This book describes a broad range of methods, including continuous and discrete Fourier transforms, independent component analysis (ICA), dependent component analysis, neural networks, and fuzzy logic methods. The book then discusses applications of these theoretical tools to practical problems in everyday biosignal processing, considering such subjects as exploratory data analysis and low-frequency connectivity analysis in MRI, MRI signal processing including lesion detection in breast MRI, dynamic cerebral contrast-enhanced perfusion MRI, skin lesion classification, and microscopic slice image processing and automatic labeling.

The renaissance of deep learning has provided promising solutions to various tasks. While conventional deep learning models are constructed for a single specific task, multi-task deep learning (MTDL) that is capable to simultaneously accomplish at least two tasks has attracted research attention. MTDL is a joint learning paradigm that harnesses the inherent correlation of multiple related tasks to achieve reciprocal benefits in improving performance, enhancing generalizability, and reducing the overall computational cost. This review focuses on the advanced applications of MTDL for medical image computing and analysis. We first summarize four popular MTDL network architectures (i.e., cascaded, parallel, interacted, and hybrid). Then, we review the representative MTDL-based networks for eight application areas, including the brain, eye, chest, cardiac, abdomen, musculoskeletal, pathology, and other human body regions. While MTDL-based medical image processing has been flourishing and demonstrating outstanding performance in many tasks, in the meanwhile, there are performance gaps in some tasks, and accordingly we perceive the open challenges and the perspective trends. For instance, in the 2018 Ischemic Stroke Lesion Segmentation challenge, the reported top dice score of 0.51 and top recall of 0.55 achieved by the cascaded MTDL model indicate further research efforts in high demand to escalate the performance of current models. •A comprehensive review of multi-task deep learning (MTDL) performed on the medical image is provided.•Four popular MTDL network architectures of cascaded, parallel, interacted, and hybrid are summarized.•Representative MTDL-based applications for eight human body regions are highlighted.•Five open challenges and related research trends are discussed.

In the last decade, research on artificial intelligence has seen rapid growth with deep learning models, especially in the field of medical image segmentation. Various studies demonstrated that these models have powerful prediction capabilities and achieved similar results as clinicians. However, recent studies revealed that the evaluation in image segmentation studies lacks reliable model performance assessment and showed statistical bias by incorrect metric implementation or usage. Thus, this work provides an overview and interpretation guide on the following metrics for medical image segmentation evaluation in binary as well as multi-class problems: Dice similarity coefficient, Jaccard, Sensitivity, Specificity, Rand index, ROC curves, Cohen’s Kappa, and Hausdorff distance. Furthermore, common issues like class imbalance and statistical as well as interpretation biases in evaluation are discussed. As a summary, we propose a guideline for standardized medical image segmentation evaluation to improve evaluation quality, reproducibility, and comparability in the research field.

Artificial intelligence (AI) advancements, especially deep learning, have significantly improved medical image processing and analysis in various tasks such as disease detection, classification, and anatomical structure segmentation. This work overviews fundamental concepts, state-of-the-art models, and publicly available datasets in the field of medical imaging. First, we introduce the types of learning problems commonly employed in medical image processing and then proceed to present an overview of commonly used deep learning methods, including convolutional neural networks (CNNs), recurrent neural networks (RNNs), and generative adversarial networks (GANs), with a focus on the image analysis task they are solving, including image classification, object detection/localization, segmentation, generation, and registration. Further, we highlight studies conducted in various application areas, encompassing neurology, brain imaging, retinal analysis, pulmonary imaging, digital pathology, breast imaging, cardiac imaging, bone analysis, abdominal imaging, and musculoskeletal imaging. The strengths and limitations of each method are carefully examined, and the paper identifies pertinent challenges that still require attention, such as the limited availability of annotated data, variability in medical images, and the interpretability issues. Finally, we discuss future research directions with a particular focus on developing explainable deep learning methods and integrating multi-modal data.

Efficient and reliable storage, analysis, and transmission of medical images are imperative for accurate diagnosis, treatment, and management of various diseases. Since quantum computing can revolutionize big data analytics by providing faster solutions and security tactics, numerous studies in this field have focused on the use of quantum and quantum-inspired algorithms to enhance the performance of traditional medical image processing approaches. This review aims to provide readers with a succinct yet adequate compendium of the advances in medical image processing combined with quantum behaviors for disease diagnosis and medical image security. Some open challenges are outlined, identifying the performance limitations of current quantum technology in their applications, while addressing the short-, medium-, and long-term development plans of this field in designing future quantum healthcare systems. We hope that this review will provide full guidance for upcoming researchers interested in this area and will stimulate further appetite of experts already active in this area aimed at the pursuit of more advanced quantum paradigms in medical image processing applications.

Fundamentals of Light Microscopy and Electronic Imaging, Second Edition provides a coherent introduction to the principles and applications of the integrated optical microscope system, covering both theoretical and practical considerations. It expands and updates discussions of multi-spectral imaging, intensified digital cameras, signal colocalization, and uses of objectives, and offers guidance in the selection of microscopes and electronic cameras, as well as appropriate auxiliary optical systems and fluorescent tags.The book is divided into three sections covering optical principles in diffraction and image formation, basic modes of light microscopy, and components of modern electronic imaging systems and image processing operations. Each chapter introduces relevant theory, followed by descriptions of instrument alignment and image interpretation. This revision includes new chapters on live cell imaging, measurement of protein dynamics, deconvolution microscopy, and interference microscopy. PowerPoint slides of the figures as well as other supplementary materials for instructors are available at a companion website: www.wiley.com/go/murphy/lightmicroscopy

Generative Adversarial Networks (GANs) have shown promising prospects and achieved significant results in medical image analysis tasks. This article provides a comprehensive review of recent research on GANs and their variants in medical applications, including tasks such as image synthesis, segmentation, classification, detection, denoising, reconstruction, fusion, registration, and prediction. We summarize and analyze the reviewed literature, with a focus on model framework design,dataset sources, and performance evaluation. Our research findings are presented in the form of tables. In the end,article discusses open challenges and directions for future research.

Semi-supervised learning methods have been attracting much attention in medical image segmentation due to the lack of high-quality annotation. To cope with the noise problem of pseudo-label in semi-supervised medical image segmentation and the limitations of contrastive learning applications, we propose a semi-supervised medical image segmentation framework, HPFG, based on hybrid pseudo-label and feature-guiding, which consists of a hybrid pseudo-label strategy and two different feature-guiding modules. The hybrid pseudo-label strategy uses the CutMix operation and an auxiliary network to enable the labeled images to guide the unlabeled images to generate high-quality pseudo-label and reduce the impact of pseudo-label noise. In addition, a feature-guiding encoder module based on feature-level contrastive learning is designed to guide the encoder to mine useful local and global image features, thus effectively enhancing the feature extraction capability of the model. At the same time, a feature-guiding decoder module based on adaptive class-level contrastive learning is designed to guide the decoder in better extracting class information, achieving intra-class affinity and inter-class separation, and effectively alleviating the class imbalance problem in medical datasets. Extensive experimental results show that the segmentation performance of the HPFG framework proposed in this paper outperforms existing semi-supervised medical image segmentation methods on three public datasets: ACDC, LIDC, and ISIC. Code is available at https://github.com/fakerlove1/HPFG.

•An open-source platform (DomainATM) for domain adaptation in medical imaging.•Fast facilitation and customization of domain adaptation for medical data.•Both feature-level and image-level adaptation methods.•User-friendly GUI and interface for self-defined algorithms.•Three examples with synthetic data, structural and functional MRIs. Domain adaptation (DA) is an important technique for modern machine learning-based medical data analysis, which aims at reducing distribution differences between different medical datasets. A proper domain adaptation method can significantly enhance the statistical power by pooling data acquired from multiple sites/centers. To this end, we have developed the Domain Adaptation Toolbox for Medical data analysis (DomainATM) – an open-source software package designed for fast facilitation and easy customization of domain adaptation methods for medical data analysis. The DomainATM is implemented in MATLAB with a user-friendly graphical interface, and it consists of a collection of popular data adaptation algorithms that have been extensively applied to medical image analysis and computer vision. With DomainATM, researchers are able to facilitate fast feature-level and image-level adaptation, visualization and performance evaluation of different adaptation methods for medical data analysis. More importantly, the DomainATM enables the users to develop and test their own adaptation methods through scripting, greatly enhancing its utility and extensibility. An overview characteristic and usage of DomainATM is presented and illustrated with three example experiments, demonstrating its effectiveness, simplicity, and flexibility. The software, source code, and manual are available online.

Significance: Skin cancer is one of the most prevalent cancers worldwide. In the advent of medical digitization and telepathology, hyper/multispectral imaging (HMSI) allows for noninvasive, nonionizing tissue evaluation at a macroscopic level. Aim: We aim to summarize proposed frameworks and recent trends in HMSI-based classification and segmentation of gross-level skin tissue. Approach: A systematic review was performed, targeting HMSI-based systems for the classification and segmentation of skin lesions during gross pathology, including melanoma, pigmented lesions, and bruises. The review adhered to the 2020 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. For eligible reports published from 2010 to 2020, trends in HMSI acquisition, preprocessing, and analysis were identified. Results: HMSI-based frameworks for skin tissue classification and segmentation vary greatly. Most reports implemented simple image processing or machine learning, due to small training datasets. Methodologies were evaluated on heavily curated datasets, with the majority targeting melanoma detection. The choice of preprocessing scheme influenced the performance of the system. Some form of dimension reduction is commonly applied to avoid redundancies that are inherent in HMSI systems. Conclusions: To use HMSI for tumor margin detection in practice, the focus of system evaluation should shift toward the explainability and robustness of the decision-making process.