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Highlights our medical achievements and the lives of key figures that helped it all come to fruition.

The Turnstone is a vivid and wide-ranging account of more than sixty years of travel, medical research and clinical practice. Geoffrey Dean was born in Wales in 1918 and trained as a doctor in Liverpool before serving with distinction as a medical officer in Bomber Command. After the war he moved to South Africa, where he lived with his family for the next twenty years. During this period Dean studied the epidemiology of porphyria, a disease that can cause paralysis; his book The Porphyrias was first published in 1963. Geoffrey Dean became Director of the Medico-Social Research Board of Ireland in 1968. The author’s research has taken him around the world, and besides his research findings, the book has a rich array of anecdotes and adventures, ranging from the threat of imprisonment in South Africa to a period spent as the personal physician to the multi-millionaire Governor of the Fiji Islands.

\"In proving the existence of stem cells, Ernest Armstrong McCulloch and James Edgar Till formed the most important partnership in Canadian medical research since Frederick Banting and Charles Best, the discoverers of insulin. Together, Till and McCulloch instructed, influenced, and inspired successive generations of researchers who have used their findings to make huge advances against disease. Thousands of people who would have died from leukemia and immunological disorders now owe their lives to therapies supported by their seminal discoveries\"-- Dust jacket flap.

Since the turn of the new millennium, 'translational research', the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe.  Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline's most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami's career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established 'rational drug design' as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami's story and that of the evolution of translation are intimately entwined: the contours of Cerami's career shaped by developments in translation, and in exchange, the field itself molded by Cerami's work.  To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century - research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet.  We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs.  Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami's life in translation.  This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book.  In many respects, Cerami's life reflects the modern metaphor of the 'American dream' with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in  the highest echelons of the US scientific establishment.  His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease.  Anthony Cerami's work has shown how science has become an important force for social change by laying the foundations of modern translational medicine. 

An obituary for professor Jean D. Wilson, who died on June 13, 2021 at the age of 88, is presented. As a fifth-generation Texan, Jean exemplified the pioneer spirit by exploring previously unsolved questions in endocrinology, including unraveling the physiologic basis of male sex differentiation and mechanisms of androgen action.

As the ground war in Vietnam escalated in the late 1960s, the US government leveraged the so-called doctor draft to secure adequate numbers of medical personnel in the armed forces. Among newly minted physicians’ few alternatives to military service was the Clinical Associate Training Program at the National Institutes of Health. Though only a small percentage of applicants were accepted, the elite program launched an unprecedented number of remarkable scientific careers that would revolutionize medicine at the end of the twentieth century. Medal Winners recounts this overlooked chapter and unforeseen byproduct of the Vietnam War through the lives of four former NIH clinical associates who would go on to become Nobel laureates. Raymond S. Greenberg traces their stories from their pre-NIH years and apprenticeships through their subsequent Nobel Prize–winning work, which transformed treatment of heart disease, cancer, and other diseases. Greenberg shows how the Vietnam draft unintentionally ushered in a golden era of research by bringing talented young physicians under the tutelage of leading scientists and offers a lesson in what it may take to replicate such a towering center of scientific innovation as the NIH in the 1960s and 1970s.

1935-2023 With hearts deeply saddened, the Eastern Mediterranean Health Journal offers its sincere condolences and heartfelt sympathy to the wife and two sons of Professor Mahmoud Fahmy Fathalla, a long-standing member of the Editorial Board of the Journal. Dr Fathalla assumed his role as Director of the UN's Special Programme on Human Reproduction (HRP) from 1989 to 1992, after two years as a researcher with HRP and the World Health Organization (WHO) and years of work as a renowned doctor and Professor of Obstetrics & Gynaecology at Assiut University, Egypt. Il a également reçu plusieurs prix internationaux, dont le World Academy of Art and Science et le Family Health de l'OMS en 2001.

An obituary for Tadataka Yamada, a scientist, an entrepreneur, an outstanding mentor, a leader in academic medicine and global health, and an industry pioneer, who died at the age of 76, is presented. Yamada completed his residency at the Medical College of Virginia, where he first became interested in gastroenterology. He then completed a gastroenterology fellowship at UCLA and subsequently accepted a position at the University of Michigan, where he was the chief of gastroenterology and then the chairman of medicine. While still at the University of Michigan, Yamada agreed to serve on the board of directors at SmithKline Beecham, and during that time realized that \"making medicines is maybe the hardest task in biomedical science\". This realization led him to accept a position as Chairman of Research and Development at GlaxoSmithKline. As an \"outsider\" to pharmaceutical development, he was able to identify areas of redundancy and where bureaucracy was creating inefficiencies. His insights helped GSK nearly double its portfolio of pharmaceuticals in development.