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Black's medical dictionary
\"Black's Medical Dictionary has been the best-selling medical dictionary for over 100 years. It is invaluable as a home reference and for all who need clear explanation of medical terms: nurses, health care professionals and students, health service management, actuaries, lawyers and journalists. It contains over 5000 definitions and descriptions of medical terms and concepts with over 1000 diagrams, drawings and colour illustrations. It also provides helpful appendices on common medical tests and procedures, travel and health, measurements in medicine, health economics, complementary and alternative medicine, and an address list of support professional organisations\"--Amazon.com.
Book
The imperial laboratory : experimental physiology and clinical medicine in post-Crimean Russia
Following a humiliating defeat in the Crimean War, the Russian Empire found herself exposed due to major deficiencies in her infrastructure. To gain from European scientific, technical and educational advancements, the Russian Government began to permit studies abroad and relaxed censorship, which brought a new flood of literature into the country. These measures enormously facilitated the growth of Russian science, medicine and education in the late nineteenth century, taking the Empire into a fascinating era of laboratory research, a new cultural and intellectual tradition. The Imperial Laboratory tells the story of the lives and studies of the leading Russian and German clinician-experimenters who played critical roles in the integration of physics and chemistry into physiology and clinical medicine. A principal theme is the major transformations undergone in military medicine and education. Using a wide range of Russian and German primary sources, this book offers a unique English-language insight into Russian physiology and medicine that will be of interest to both historians and doctors, as well as anyone interested in Russian science and culture.
Book
Digitale Gesundheits-Apps
Digitale Gesundheits-Apps, seit 2019 auch auf Rezept erhältlich, bieten vielfältige Funktionen in Gesundheitsmonitoring, Symptomerkennung, Verlaufsbeobachtung und Patientenversorgung. Das Digitale-Versorgungs-Gesetz von 2023 strebt eine umfassende Integration von Apps in die medizinische Versorgung an. Die Nutzung künstlicher Intelligenz (KI) in Gesundheits-Apps verspricht eine frühere Diagnosestellung, sensitive Symptomüberwachung, Optimierung von Therapieabläufen, effektivere Arzt-Patienten-Kommunikation sowie Ressourceneinsparungen. Die Integration von Gesundheits-Apps und KI kann eine stärker personalisierte, hochwertige Versorgung ermöglichen.
Journal Article
Kardiovaskuläre Prävention in Sachsen-Anhalt
Kardiovaskuläre Risikofaktoren (Bluthochdruck, Rauchen, Übergewicht, Diabetes mellitus Typ 2, Dyslipidämie, körperliche Inaktivität) steigen mit zunehmendem Alter, insbesondere ab dem mittleren Erwachsenenalter, deutlich an, wobei Frauen wesentlich stärker betroffen sind. In der Bevölkerung Sachsen-Anhalts ist die Prävalenz kardiovaskulärer Risikofaktoren stark erhöht, und die Bevölkerungsstruktur in Sachsen-Anhalt ist besonders geprägt von einem hohen Durchschnittsalter sowie einer hohen Morbiditäts- und Mortalitätsrate aufgrund von kardiovaskulären Erkrankungen. Somit bietet Sachsen-Anhalt einen Modellcharakter für die demografische Entwicklung in Europa. Dieser Übersichtsbeitrag thematisiert Strategien zur Umsetzung zielgruppenspezifischer, kardiovaskulärer Präventionsstrategien im Bundesland Sachsen-Anhalt unter besonderer Berücksichtigung von Alter und Geschlecht. Indem präventivmedizinische Einrichtungen aufgebaut und innovative Versorgungsmöglichkeiten für kardiovaskuläre Risikopatienten geschaffen werden, soll Prävention auch dem ländlichen Bereich zugänglich gemacht werden.
Journal Article
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and antibody response data from an ongoing placebo-controlled, observer-blinded phase I/II coronavirus disease 2019 (COVID-19) vaccine trial with BNT162b1, a lipid nanoparticle-formulated nucleoside-modified mRNA that encodes the receptor binding domain (RBD) of the SARS-CoV-2 spike protein
1
. Here we present antibody and T cell responses after vaccination with BNT162b1 from a second, non-randomized open-label phase I/II trial in healthy adults, 18–55 years of age. Two doses of 1–50 μg of BNT162b1 elicited robust CD4
+
and CD8
+
T cell responses and strong antibody responses, with RBD-binding IgG concentrations clearly above those seen in serum from a cohort of individuals who had recovered from COVID-19. Geometric mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-μg dose) to 3.5
-
fold (50-μg dose) those of the recovered individuals. Immune sera broadly neutralized pseudoviruses with diverse SARS-CoV-2 spike variants. Most participants had T helper type 1 (T
H
1)-skewed T cell immune responses with RBD-specific CD8
+
and CD4
+
T cell expansion. Interferon-γ was produced by a large fraction of RBD-specific CD8
+
and CD4
+
T cells. The robust RBD-specific antibody, T cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest that it has the potential to protect against COVID-19 through multiple beneficial mechanisms.
In a phase I/II dose-escalation clinical trial, the mRNA COVID-19 vaccine BNT162b1 elicits specific T cell and antibody responses that suggest it has protective potential.
Journal Article
