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Sea otter pup
\"In this informative picture book a sea otter pup learns from his mother and develops his independence in the North Pacific.\"-- Provided by publisher.
Book
Climate and the Oceans
The oceans exert a vital moderating influence on the Earth's climate system. They provide inertia to the global climate, essentially acting as the pacemaker of climate variability and change, and they provide heat to high latitudes, keeping them habitable. Climate and the Oceans offers a short, self-contained introduction to the subject. This illustrated primer begins by briefly describing the world's climate system and ocean circulation and goes on to explain the important ways that the oceans influence climate. Topics covered include the oceans' effects on the seasons, heat transport between equator and pole, climate variability, and global warming. The book also features a glossary of terms, suggestions for further reading, and easy-to-follow mathematical treatments. Climate and the Oceans is the first place to turn to get the essential facts about this crucial aspect of the Earth's climate system. Ideal for students and nonspecialists alike, this primer offers the most concise and up-to-date overview of the subject available. The best primer on the oceans and climate Succinct and self-contained Accessible to students and nonspecialists Serves as a bridge to more advanced material
eBook
The Dead Sea : a 10,000 year history
\"The Dead Sea is a place of many contradictions. Hot springs around the lake are famed for their healing properties, though its own waters are deadly to most lifeforms--even so, civilizations have built ancient cities and hilltop fortresses around its shores for centuries. The protagonists in its story are not only Jews and Arabs, but also Greeks, Nabataeans, Romans, Crusaders and Mamluks. Today it has become a tourist hotspot, but its drying basin is increasingly under threat. Nir Arielli explores the history of the Dead Sea from the first Neolithic settlements to the present day. Moving through the ages, Arielli reveals the religious, economic, military, and scientific importance of the lake, which has been both a source of great wealth and a site of war. The Dead Sea weaves together a tapestry of the lake's human stories--and amidst environmental degradation and renewed conflict, makes a powerful case for why it should be saved.\"--Book jacket.
BOOK
Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak
Public health measures were decisive in controlling the SARS epidemic in 2003. Isolation is the separation of ill persons from non-infected persons. Quarantine is movement restriction, often with fever surveillance, of contacts when it is not evident whether they have been infected but are not yet symptomatic or have not been infected. Community containment includes measures that range from increasing social distancing to community-wide quarantine. Whether these measures will be sufficient to control 2019-nCoV depends on addressing some unanswered questions.
Journal Article
Seafood simple
\"In its three decades at the top of New York City's restaurant scene, Le Bernardin has been celebrated as one of the finest seafood restaurants in the world and its iconic chef Eric Ripert as the expert in fish cookery. Now, in Seafood Simple, Ripert demystifies his signature cuisine, making it accessible to home cooks of all skill levels-yet still with elegance and panache. Breaking down cooking techniques in a step-by-step process along with accompanying images, this book teaches readers how to master core skills, from poaching and deep frying to filleting a fish and shucking an oyster. These techniques are then applied to 85 straightforward, delicious recipes. Dishes like Tuna Carpaccio, Crispy Fish Tacos, Shrimp Tempura, Miso Cod, and Spaghetti Vongole show us how to bring out the vibrant flavor and incredible versatility of seafood. Each recipe is complete with a gorgeous image by renowned photographer Nigel Parry, as well as step-by-step photos for each of the twenty techniques taught in the book\"-- Provided by publisher.
Book
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
ObjectiveAcute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution of acute hepatic inflammation are largely unknown. Here, we aimed to investigate the impact of Mer tyrosine kinase (MerTK) during ALF and also examine how the microenvironmental mediator, secretory leucocyte protease inhibitor (SLPI), governs this response.DesignFlow cytometry, immunohistochemistry, confocal imaging and gene expression analyses determined the phenotype, functional/transcriptomic profile and tissue topography of MerTK+ monocytes/macrophages in ALF, healthy and disease controls. The temporal evolution of macrophage MerTK expression and its impact on resolution was examined in APAP-induced acute liver injury using wild-type (WT) and Mer-deficient (Mer−/−) mice. SLPI effects on hepatic myeloid cells were determined in vitro and in vivo using APAP-treated WT mice.ResultsWe demonstrate a significant expansion of resolution-like MerTK+HLA-DRhigh cells in circulatory and tissue compartments of patients with ALF. Compared with WT mice which show an increase of MerTK+MHCIIhigh macrophages during the resolution phase in ALF, APAP-treated Mer−/− mice exhibit persistent liver injury and inflammation, characterised by a decreased proportion of resident Kupffer cells and increased number of neutrophils. Both in vitro and in APAP-treated mice, SLPI reprogrammes myeloid cells towards resolution responses through induction of a MerTK+HLA-DRhigh phenotype which promotes neutrophil apoptosis and their subsequent clearance.ConclusionsWe identify a hepatoprotective, MerTK+, macrophage phenotype that evolves during the resolution phase following ALF and represents a novel immunotherapeutic target to promote resolution responses following acute liver injury.
Journal Article
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including myocardial infarction. Although the role of MerTK in cardioprotection is well characterized, the unique role of the other structurally similar TAMs, and particularly AXL, in clinically relevant models of myocardial ischemia/reperfusion infarction (IRI) is comparatively unknown. Utilizing complementary approaches, validated by flow cytometric analysis of human and murine macrophage subsets and conditional genetic loss and gain of function, we uncover a maladaptive role for myeloid AXL during IRI in the heart. Cross signaling between AXL and TLR4 in cardiac macrophages directed a switch to glycolytic metabolism and secretion of proinflammatory IL-1β, leading to increased intramyocardial inflammation, adverse ventricular remodeling, and impaired contractile function. AXL functioned independently of cardioprotective MerTK to reduce the efficacy of cardiac repair, but like MerTK, was proteolytically cleaved. Administration of a selective small molecule AXL inhibitor alone improved cardiac healing, which was further enhanced in combination with blockade of MerTK cleavage. These data support further exploration of macrophage TAM receptors as therapeutic targets for myocardial infarction.
Journal Article
The underworld : journeys to the depths of the ocean
\"From New York Times bestselling author Susan Casey, an awe-inspiring portrait of the mysterious world beneath the waves, and the men and women who seek to uncover its secrets For all of human history, the deep ocean has been a source of wonder and terror, an unknown realm that evoked a singular, compelling question: What's down there? Unable to answer this for centuries, people believed the deep was a sinister realm of fiendish creatures and deadly peril. But now, cutting-edge technologies allow scientists and explorers to dive miles beneath the surface, and we are beginning to understand this strange and exotic underworld: A place of soaring mountains, smoldering volcanoes, and valleys 7,000 feet deeper than Everest is high, where tectonic plates collide and separate, and extraordinary life forms operate under different rules. Far from a dark void, the deep is a vibrant realm that's home to pink gelatinous predators and shimmering creatures a hundred feet long and ancient animals with glass skeletons and sharks that live for half a millennium-among countless other marvels. Susan Casey is our premiere chronicler of the aquatic world. For The Underworld she traversed the globe, joining scientists and explorers on dives to the deepest places on the planet, interviewing the marine geologists, marine biologists, and oceanographers who are searching for knowledge in this vast unseen realm. She takes us on a fascinating journey through the history of deep-sea exploration, from the myths and legends of the ancient world to storied shipwrecks we can now reach on the bottom, to the first intrepid bathysphere pilots, to the scientists who are just beginning to understand the mind-blowing complexity and ecological importance of the quadrillions of creatures who live in realms long thought to be devoid of life. Throughout this journey, she learned how vital the deep is to the future of the planet, and how urgent it is that we understand it in a time of increasing threats from climate change, industrial fishing, pollution, and the mining companies that are also exploring its depths. The Underworld is Susan Casey's most beautiful and thrilling book yet, a gorgeous evocation of the natural world and a powerful call to arms\"-- Provided by publisher.
Book
Jack London and the Sea
The first book-length study of London as a maritime
writer Jack London’s fiction has been studied
previously for its thematic connections to the ocean, but
Jack London and the Sea marks the first time that his
life as a writer has been considered extensively in relationship
to his own sailing history and interests. In this new study,
Anita Duneer claims a central place for London in the maritime
literary tradition, arguing that for him romance and nostalgia
for the Age of Sail work with and against the portrayal of a
gritty social realism associated with American naturalism in
urban or rural settings. The sea provides a dynamic setting for
London’s navigation of romance, naturalism, and realism to
interrogate key social and philosophical dilemmas of modernity:
race, class, and gender. Furthermore, the maritime tradition
spills over into texts that are not set at sea.
Jack London and the Sea does not address all of
London’s sea stories, but rather identifies key maritime
motifs that influenced his creative process. Duneer’s
critical methodology employs techniques of literary and cultural
analysis, drawing on extensive archival research from a wealth of
previously unpublished biographical materials and other sources.
Duneer explores London’s immersion in the lore and
literature of the sea, revealing the extent to which his writing
is informed by travel narratives, sensational sea yarns, and the
history of exploration, as well as firsthand experiences as a
sailor in the San Francisco Bay and Pacific Ocean. Organized
thematically, chapters address topics that interested London:
labor abuses on “Hell-ships” and copra plantations,
predatory and survival cannibalism, strong seafaring women, and
environmental issues and property rights from San Francisco
oyster beds to pearl diving in the Paumotos. Through its
examination of the intersections of race, class, and gender in
London’s writing,
Jack London and the Sea plumbs the often-troubled waters
of his representations of the racial Other and positions of
capitalist and colonial privilege. We can see the manifestation
of these socioeconomic hierarchies in London’s depiction of
imperialist exploitation of labor and the environment, inequities
that continue to reverberate in our current age of global
capitalism.
eBook