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"Metals - toxicity"
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The poisoned city : Flint's water and the American urban tragedy /
\"Recounts the gripping story of Flint's poisoned water through the people who caused it, suffered from it, and exposed it. It is a chronicle of one town, but could also be about any American city, all made precarious by the neglect of infrastructure\"-- Provided by publisher.
Book
Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity
The escalating challenges posed by metal(loid) toxicity in agricultural ecosystems, exacerbated by rapid climate change and anthropogenic pressures, demand urgent attention. Soil contamination is a critical issue because it significantly impacts crop productivity. The widespread threat of metal(loid) toxicity can jeopardize global food security due to contaminated food supplies and pose environmental risks, contributing to soil and water pollution and thus impacting the whole ecosystem. In this context, plants have evolved complex mechanisms to combat metal(loid) stress. Amid the array of innovative approaches, omics, notably transcriptomics, proteomics, and metabolomics, have emerged as transformative tools, shedding light on the genes, proteins, and key metabolites involved in metal(loid) stress responses and tolerance mechanisms. These identified candidates hold promise for developing high-yielding crops with desirable agronomic traits. Computational biology tools like bioinformatics, biological databases, and analytical pipelines support these omics approaches by harnessing diverse information and facilitating the mapping of genotype-to-phenotype relationships under stress conditions. This review explores: (1) the multifaceted strategies that plants use to adapt to metal(loid) toxicity in their environment; (2) the latest findings in metal(loid)-mediated transcriptomics, proteomics, and metabolomics studies across various plant species; (3) the integration of omics data with artificial intelligence and high-throughput phenotyping; (4) the latest bioinformatics databases, tools and pipelines for single and/or multi-omics data integration; (5) the latest insights into stress adaptations and tolerance mechanisms for future outlooks; and (6) the capacity of omics advances for creating sustainable and resilient crop plants that can thrive in metal(loid)-contaminated environments.
Journal Article
Metal Toxicity: Effects on Energy Metabolism in Fish
Metals are dispersed in natural environments, particularly in the aquatic environment, and accumulate, causing adverse effects on aquatic life. Moreover, chronic polymetallic water pollution is a common problem, and the biological effects of exposure to complex mixtures of metals are the most difficult to interpret. In this review, metal toxicity is examined with a focus on its impact on energy metabolism. Mechanisms regulating adenosine triphosphate (ATP) production and reactive oxygen species (ROS) emission are considered in their dual roles in the development of cytotoxicity and cytoprotection, and mitochondria may become target organelles of metal toxicity when the transmembrane potential is reduced below its phosphorylation level. One of the main consequences of metal toxicity is additional energy costs, and the metabolic load can lead to the disruption of oxidative metabolism and enhanced anaerobiosis.
Journal Article
Dual Role of Metallic Trace Elements in Stress Biology—From Negative to Beneficial Impact on Plants
Heavy metals are an interesting group of trace elements (TEs). Some of them are minutely required for normal plant growth and development, while others have unknown biological actions. They may cause injury when they are applied in an elevated concentration, regardless of the importance for the plant functioning. On the other hand, their application may help to alleviate various abiotic stresses. In this review, both the deleterious and beneficial effects of metallic trace elements from their uptake by roots and leaves, through toxicity, up to the regulation of physiological and molecular mechanisms that are associated with plant protection against stress conditions have been briefly discussed. We have highlighted the involvement of metallic ions in mitigating oxidative stress by the activation of various antioxidant enzymes and emphasized the phenomenon of low-dose stimulation that is caused by non-essential, potentially poisonous elements called hormesis, which is recently one of the most studied issues. Finally, we have described the evolutionary consequences of long-term exposure to metallic elements, resulting in the development of unique assemblages of vegetation, classified as metallophytes, which constitute excellent model systems for research on metal accumulation and tolerance. Taken together, the paper can provide a novel insight into the toxicity concept, since both dose- and genotype-dependent response to the presence of metallic trace elements has been comprehensively explained.
Journal Article
Assessing Metal Toxicity on Crustaceans in Aquatic Ecosystems: A Comprehensive Review
Residual concentrations of some trace elements and lightweight metals, including cadmium, copper, lead, mercury, silver, zinc, nickel, chromium, arsenic, gallium, indium, gold, cobalt, polonium, and thallium, are widely detected in aquatic ecosystems globally. Although their origin may be natural, human activities significantly elevate their environmental concentrations. Metals, renowned pollutants, threaten various organisms, particularly crustaceans. Due to their feeding habits and habitat, crustaceans are highly exposed to contaminants and are considered a crucial link in xenobiotic transfer through the food chain. Moreover, crustaceans absorb metals via their gills, crucial pathways for metal uptake in water. This review summarises the adverse effects of well-studied metals (Cd, Cu, Pb, Hg, Zn, Ni, Cr, As, Co) and synthesizes knowledge on the toxicity of less-studied metals (Ag, Ga, In, Au, Pl, Tl), their presence in waters, and impact on crustaceans. Bibliometric analysis underscores the significance of this topic. In general, the toxic effects of the examined metals can decrease survival rates by inducing oxidative stress, disrupting biochemical balance, causing histological damage, interfering with endocrine gland function, and inducing cytotoxicity. Metal exposure can also result in genotoxicity, reduced reproduction, and mortality. Despite current toxicity knowledge, there remains a research gap in this field, particularly concerning the toxicity of rare earth metals, presenting a potential future challenge.
Journal Article
Chronic effects of metal releases from historical mining on threatened crayfish in Madison County Missouri, USA
The Little St. Francis River and its tributaries drain metals-contaminated areas of the Madison County Mines National Priority List Superfund site (MCM) which was designated in 2003 to facilitate remediation of metals contamination within the MCM. One concern for natural resource trustees in the MCM is the potential effects of elevated metals concentrations on the federally threatened St. Francis River crayfish, Faxonius quadruncus, which has a geographic range that is limited to the St. Francis River watershed. A survey of riffle-dwelling crayfish, in-situ cage study, and laboratory toxicity tests were conducted to assess the effects of mining-derived metals on F. quadruncus and other crayfish species in the MCM. Crayfish densities were significantly greater at sites upstream of metals releases from historical mining (henceforth mining releases) compared to densities at sites downstream of mining releases, and metals concentrations in whole-body crayfish, surface water, sediments, macroinvertebrates, fish, and plant material were greater at sites downstream of mining releases compared to sites upstream of mining releases. Crayfish densities were also negatively correlated with consensus-based adverse effects indices, expressed as surface-water toxic units and sediment probable effects quotients. Decreased growth and increased mortality during cage and laboratory studies were likely due to exposure to, and subsequently uptake of, elevated concentrations of metals. Crayfish in all studies were found to bioaccumulate metals, which supports their utility as bioindicators of metals contamination. Study results show that elevated metals concentrations associated with mining releases in the MCM continue to adversely affect biota, including the federally threatened F. quadruncus.
Journal Article
Contaminant Metals and Cardiovascular Health
A growing body of research has begun to link exposure to environmental contaminants, such as heavy metals, with a variety of negative health outcomes. In this paper, we sought to review the current research describing the impact of certain common contaminant metals on cardiovascular (CV) health. We reviewed ten metals: lead, barium, nickel, chromium, cadmium, arsenic, mercury, selenium, zinc, and copper. After a literature review, we briefly summarized the routes of environmental exposure, pathophysiological mechanisms, CV health impacts, and exposure prevention and/or mitigation strategies for each metal. The resulting article discloses a broad spectrum of pathological significance, from relatively benign substances with little to no described effects on CV health, such as chromium and selenium, to substances with a wide-ranging and relatively severe spectrum of CV pathologies, such as arsenic, cadmium, and lead. It is our hope that this article will provide clinicians with a practical overview of the impact of these common environmental contaminants on CV health as well as highlight areas that require further investigation to better understand how these metals impact the incidence and progression of CV diseases.
Journal Article
Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles
It is expected that the number and variety of engineered nanoparticles will increase rapidly over the next few years
1
, and there is a need for new methods to quickly test the potential toxicity of these materials
2
. Because experimental evaluation of the safety of chemicals is expensive and time-consuming, computational methods have been found to be efficient alternatives for predicting the potential toxicity and environmental impact of new nanomaterials before mass production. Here, we show that the quantitative structure–activity relationship (QSAR) method commonly used to predict the physicochemical properties of chemical compounds can be applied to predict the toxicity of various metal oxides. Based on experimental testing, we have developed a model to describe the cytotoxicity of 17 different types of metal oxide nanoparticles to bacteria
Escherichia coli
. The model reliably predicts the toxicity of all considered compounds, and the methodology is expected to provide guidance for the future design of safe nanomaterials.
Approaches in quantitative structure–activity relationships developed to predict the physical and chemical properties of chemical compounds can also be used to predict the toxicity of nanoparticles.
Journal Article
Nanoparticles based on essential metals and their phytotoxicity
Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comprehensively summarize the latest findings on the phytotoxicity of nanomaterial products based on essential metals used in plant protection. The metal nanoparticles (NPs) synthesized from essential metals belong to the most commonly manufactured types of nanomaterials since they have unique physical and chemical properties and are used in agricultural and biotechnological applications, which are discussed. The paper discusses the interactions of nanomaterials and vascular plants, which are the subject of intensive research because plants closely interact with soil, water, and atmosphere; they are also part of the food chain. Regarding the accumulation of NPs in the plant body, their quantification and localization is still very unclear and further research in this area is necessary.
Journal Article
An Overview of Bacteria-Mediated Heavy Metal Bioremediation Strategies
Contamination-free groundwater is considered a good source of potable water. Even in the twenty-first century, over 90 percent of the population is reliant on groundwater resources for their lives. Groundwater influences the economical state, industrial development, ecological system, and agricultural and global health conditions worldwide. However, different natural and artificial processes are gradually polluting groundwater and drinking water systems throughout the world. Toxic metalloids are one of the major sources that pollute the water system. In this review work, we have collected and analyzed information on metal-resistant bacteria along with their genetic information and remediation mechanisms of twenty different metal ions [arsenic (As), mercury (Hg), lead (Pb), chromium (Cr), iron (Fe), copper (Cu), cadmium (Cd), palladium (Pd), zinc (Zn), cobalt (Co), antimony (Sb), gold (Au), silver (Ag), platinum (Pt), selenium (Se), manganese (Mn), molybdenum (Mo), nickel (Ni), tungsten (W), and uranium (U)]. We have surveyed the scientific information available on bacteria-mediated bioremediation of various metals and presented the data with responsible genes and proteins that contribute to bioremediation, bioaccumulation, and biosorption mechanisms. Knowledge of the genes responsible and self-defense mechanisms of diverse metal-resistance bacteria would help us to engineer processes involving multi-metal-resistant bacteria that may reduce metal toxicity in the environment.
Journal Article