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Improving the resolution of microscope by deconvolution after dense scan
Super-resolution microscopes (such as STED) illuminate samples with a tiny spot, and achieve very high resolution. But structures smaller than the spot cannot be resolved in this way. Therefore, we propose a technique to solve this problem. It is termed “Deconvolution after Dense Scan (DDS)”. First, a preprocessing stage is introduced to eliminate the optical uncertainty of the peripheral areas around the sample’s ROI (Region of Interest). Then, the ROI is scanned densely together with its peripheral areas. Finally, the high resolution image is recovered by deconvolution. The proposed technique does not need to modify the apparatus much, and is mainly performed by algorithm. Simulation experiments show that the technique can further improve the resolution of super-resolution microscopes.
Journal Article
All in a drop : how Antony van Leeuwenhoek discovered an invisible world
\"For fans of the 'Who Was' series, this lively, accessible, and full-color chapter book biography shows how a self-taught scientist was the first to observe the microbial life in and around us. By building his own microscope, Antony van Leeuwenhoek advanced humanity's understanding of our oft-invisible world around us\"-- Provided by publisher.
Book
Improving the resolution of microscope by deconvolution after dense scan
Super-resolution microscopes (such as STED) illuminate samples with a tiny spot, and achieve very high resolution. But structures smaller than the spot cannot be resolved in this way. Therefore, we propose a technique to solve this problem. It is termed “Deconvolution after Dense Scan (DADS)”. First, a preprocessing stage is introduced to eliminate the optical uncertainty of the peripheral areas around the sample’s ROI (Region of Interest). Then, the ROI is scanned densely together with its peripheral areas. Finally, the high resolution image is recovered by deconvolution. The proposed technique does not need to modify the apparatus much, and is mainly performed by algorithm. Simulation experiments show that the technique can further improve the resolution of super-resolution microscopes.
Journal Article
Antoni van Leeuwenhoek : genius discoverer of microscopic life
\"A biography of seventeenth-century Dutch scientist Antoine van Leeuwenhoek and includes related activities for readers\"--Provided by publishers.
Book
Statistical features of concrete destruction at background intensity of seismic impacts
The results of analytical studies of the effect of statistical asymmetry on the controlled parameters of concrete under the seismic effect of background intensity.
Journal Article
Close Up and Far Out : Seeing the World Differently
\"An illustrated picture book of early scientists Antonie van Leeuwenhoek and Galileo Galilei, who used similar observation tools but saw the world very differently, their discoveries leading to innovations in both microscopes and telescopes.\" -- Provided by publisher.
BOOK
Searching for conditions of protein self-assembly by protein crystallization screening method
The self-assembly of biomacromolecules is an extremely important process. It is potentially useful in the fields of life science and materials science. To carry out the study on the self-assembly of proteins, it is necessary to find out the suitable self-assembly conditions, which have always been a challenging task in practice. Inspired by the screening technique in the field of protein crystallization, we proposed using the same screening technique for seeking suitable protein self-assembly conditions. Based on this consideration, we selected 5 proteins (β-lactoglobulin, hemoglobin, pepsin, lysozyme, α-chymotrypsinogen (II) A) together with 5 screening kits (IndexTM, BML, Morpheus, JCSG, PEG/Ion ScreenTM) to investigate the performance of these crystallization screening techniques in order to discover new optimized conditions of protein self-assembly. The screens were all kept at 293 K for certain days, and were analyzed using optical microscope, scanning electron microscope, transmission electron microscope, atomic force microscope, fluorescence microscope, and atomic absorption spectroscope. The results demonstrated that the method of protein crystallization screening can be successfully applied in the screening of self-assembly conditions. This method is fast, high throughput, and easily implemented in an automated system, with a low protein consumption feature. These results suggested that such strategy can be applied to finding new conditions or forms in routine research of protein self-assembly.Key points• Protein crystallization screening method is successfully applied in the screening of self-assembly conditions.• This screening method can be applied on various kinds of proteins and possess a feature of low protein consumption.• This screening method is fast, high throughput, and easily implemented in an automated system.
Journal Article
Abbas El Gamal and Mark Schnitzer
Two-gram microscopes make brain images in moving mice.
Journal Article