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Depeche Mode : Monument
Preface -- Basildon -- Speak & spell -- A broken frame -- Construction time again -- Some great reward -- The singles 81-85 -- Black celebration -- Music for the masses -- Violator -- Songs of faith and devotion -- Ultra -- Exciter -- Playing the angel -- Sounds of the universe -- Delta machine -- Spirit -- Fan culture in the East and West -- Appendix
Book
Catecholaminergic Modulation of Large‐Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity
Large‐scale brain network function is critical for healthy cognition, yet links between such network function, neurochemistry, and smaller‐scale neurocircuitry are unclear. Here, we evaluated 59 healthy individuals using resting‐state fMRI to determine how network‐level temporal dynamics were impacted by two well‐characterized pharmacotherapies targeting catecholamines: methylphenidate (20 mg) and haloperidol (2 mg)—administered via randomized, double‐blind, placebo‐controlled design. Network temporal dynamic changes were tested for links with drug‐induced alterations in complex corticostriatal connections as this circuit is a primary site of action for both drugs. Methylphenidate increased time in the default mode network state (DMN p < 0.001) and dorsal attention network state (DAN p < 0.001) and reduced time in the frontoparietal network state (p < 0.01). Haloperidol increased time in a sensory motor‐DMN state (p < 0.01). The magnitude of change in network dynamics induced by methylphenidate vs. placebo correlated with the magnitude of methylphenidate‐induced rearrangement of complex corticostriatal connectivity (R = 0.32, p = 0.014). Haloperidol did not alter complex corticostriatal connectivity. Methylphenidate enhanced time in network states involved in internal and external attention (DMN and DAN, respectively), aligning with methylphenidate's established role in attention. Methylphenidate also significantly changed complex corticostriatal connectivity by altering the relative strength between multiple corticostriatal connections, indicating that methylphenidate may shift which corticostriatal connections are prioritized relative to others. Findings show that these corticostriatal circuit changes are linked with large‐scale network temporal dynamics. Collectively, these findings provide a deeper understanding of large‐scale network function, set a stage for mechanistic understanding of network engagement, and provide useful information to guide medication use based on network‐level effects. Trial Registration: Registry name: ClinicalTrials.gov; URL: Brain Networks and Addiction Susceptibility—Full Text View—ClinicalTrials.gov; URL Plain text: https://classic.clinicaltrials.gov/ct2/show/NCT01924468; Identifier: NCT01924468 At rest, the dopamine/norepinephrine agonist, methylphenidate, enhances time spent in external and internal attentional neurobiological states (DAN and DMN, respectively), suggesting the brain is primed to respond to different attentional demands. Large‐scale network dynamics relate to drug‐induced changes in complex corticostriatal connectivity, revealing direct links between circuit‐level and network‐level effects.
Journal Article
Single VDGA-Based Mixed-Mode Universal Filter and Dual-Mode Quadrature Oscillator
This article presents the circuit designs for a mixed-mode universal biquadratic filter and a dual-mode quadrature oscillator, both of which use a single voltage differencing gain amplifier (VDGA), one resistor, and two capacitors. The proposed circuit has the following performance characteristics: (i) simultaneous implementation of standard biquadratic filter functions with three inputs and two outputs in all four possible modes, namely, voltage-mode (VM), current-mode (CM), trans-admittance-mode (TAM), and trans-impedance-mode (TIM); (ii) electronic adjustment of the natural angular frequency and independently single-resistance controllable high-quality factor; (iii) performing a dual-mode quadrature oscillator with simultaneous voltage and current output responses; (iv) orthogonal resistive and/or electronic control of the oscillation condition and frequency; (v) employing all grounded passive components in the quadrature oscillator function; and (vi) simpler topology due to the use of a single VDGA. VDGA non-idealities and parasitic elements are also investigated and analyzed in terms of their influence on circuit performance. To prove the study hypotheses, computer simulations with TSMC 0.18 μm CMOS technology and experimental confirmatory testing with off-the-shelf integrated circuits LM13600 have been performed.
Journal Article
Realisation of new single-layer triple-mode substrate-integrated waveguide and dual-mode half-mode substrate-integrated waveguide filters using a circular shape perturbation
A method of ‘mode shifting’ is presented for realisation of triple-mode and dual-mode filters, in which the resonant frequency of one mode is shifted near to the resonant frequency of another mode using a perturbation. To realise a triple-mode filter, a single-layer substrate-integrated waveguide (SIW) square cavity is perturbed by introducing vias at the middle of the structure. This perturbation causes mode shifting of the dominant mode (TE101) near to the next modes (TE102 and TE201). Operation of this triple-mode resonator is analysed and resonant frequencies of the perturbed cavity are obtained theoretically. A triple-mode filter is realised using this resonator and the filter is modelled by a coupling matrix based on the global eigenmodes. Moreover, by using the mode shifting technique, a novel dual-mode bandpass filter with half-mode SIW (HMSIW) structure is presented. Both the triple-mode SIW and dual-mode HMSIW filters are fabricated on a single-layer substrate using a printed circuit board process.
Journal Article
Jeremy Scott
The definitive monograph on Jeremy Scott, one of the most creative and influential American designers working in fashion today. Jeremy Scott is an American designer whose sensibility has brought elements of humor, rebellion, and fantasy to the elevated culture of couture - from his earliest collections in Paris to the outrageous runway shows in recent years that led the New York Times to call him 'fashion's last rebel.' Creative, original, and iconic, Scott is the voice of his generation, his work a colourful marriage of the ubiquity of cultural reference with the refinement of high fashion.
Book
Psilocybin desynchronizes the human brain
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials
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. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus
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. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6–12 months later. Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate. These FC changes were driven by brain desynchronization across spatial scales (areal, global), which dissolved network distinctions by reducing correlations within and anticorrelations between networks. Psilocybin-driven FC changes were strongest in the default mode network, which is connected to the anterior hippocampus and is thought to create our sense of space, time and self. Individual differences in FC changes were strongly linked to the subjective psychedelic experience. Performing a perceptual task reduced psilocybin-driven FC changes. Psilocybin caused persistent decrease in FC between the anterior hippocampus and default mode network, lasting for weeks. Persistent reduction of hippocampal-default mode network connectivity may represent a neuroanatomical and mechanistic correlate of the proplasticity and therapeutic effects of psychedelics.
Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disrupt functional connectivity in cortex and subcortex with some changes persisting for weeks.
Journal Article
Fabric for fashion : the complete guide : natural and man-made fibers
Fabric For Fashion: The Complete Guide is the only book specifically for fashion designers to explain the behaviour and properties of different fabrics. Fashion design is largely determined by how the fabrics work, move, feel and look. The most successful fashion designers are those who understand their materials, who match design skill with technical knowledge. This book bridges that gap by providing a mix of practical information and industry vocabulary, visually examining generic fabric types, discussing the characteristics of fabrics and showing how to exploit materials to push the boundaries of design. With stunning colour photographs that show how fashion designers, both past and present, have worked with fabrics, the books prime objective is to stimulate creative exploration of the relationship of fabrics to fashion.
Book
Development of the default-mode network during childhood and adolescence: A longitudinal resting-state fMRI study
The default-mode network (DMN) is a set of functionally connected regions that play crucial roles in internal cognitive processing. Previous resting-state fMRI studies have demonstrated that the intrinsic functional organization of the DMN undergoes remarkable reconfigurations during childhood and adolescence. However, these studies have mainly focused on cross-sectional designs with small sample sizes, limiting the consistency and interpretations of the findings. Here, we used a large sample of longitudinal resting-state fMRI data comprising 305 typically developing children (6–12 years of age at baseline, 491 scans in total) and graph theoretical approaches to delineate the developmental trajectories of the functional architecture of the DMN. For each child, the DMN was constructed according to a prior parcellation with 32 brain nodes. We showed that the overall connectivity increased in strength from childhood to adolescence and became spatially similar to that in the young adult group (N = 61, 18–28 years of age). These increases were primarily located in the midline structures. Global and local network efficiency in the DMN also increased with age, indicating an enhanced capability in parallel information communication within the brain system. Based on the divergent developmental rates of nodal centrality, we identified three subclusters within the DMN, with the fastest rates in the cluster mainly comprising the anterior medial prefrontal cortex and posterior cingulate cortex. Together, our findings highlight the developmental patterns of the functional architecture in the DMN from childhood to adolescence, which has implications for the understanding of network mechanisms underlying the cognitive development of individuals.
Journal Article