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Molecules : the elements and the architecture of everything
\"Everything physical is made up of the elements and the infinite variety of molecules they form when they combine with each other. In [this book], Gray takes the next step in the grand story that began with the periodic table in his best-selling book The Elements ... Here, he explores ... the most interesting, essential, useful, and beautiful of the millions of chemical structures that make up every material in the world\"--Amazon.com.
Book
Bright photoactivatable fluorophores for single-molecule imaging
Small-molecule fluorophores are important tools for advanced imaging experiments. We previously reported a general method to improve small, cell-permeable fluorophores which resulted in the azetidine-containing 'Janelia Fluor' (JF) dyes. Here, we refine and extend the utility of these dyes by synthesizing photoactivatable derivatives that are compatible with live-cell labeling strategies. Once activated, these derived compounds retain the superior brightness and photostability of the JF dyes, enabling improved single-particle tracking and facile localization microscopy experiments.
Journal Article
What do you know about atoms and molecules?
Basic information about atoms and molecules and their properties.
Book
Monomers, Polymers and Composites from Renewable Resources
This collection of chapters, each one written by internationally recognized experts in the corresponding field, covers in a comprehensive fashion all the major aspects related to the synthesis, characterization and properties of macromolecular materials prepared using renewable resources as such, or after appropriate modifications. Thus, monomers such as terpenes and furans, oligomers like rosin and tannins, and polymers ranging from cellulose to proteins and including macromolecules synthesized by microbes, are discussed with the purpose of showing the extraordinary variety of materials that can be prepared from their intelligent exploitation. Particular emphasis has been placed on recent advances and imminent perspectives, given the incessantly growing interest that this area is experiencing in both the scientific and technological realms. The book discusses bio-refining with explicit application to materials, replete with examples of applications of the concept of sustainable development, and presents an impressive variety of novel macromolecular materials. This book is suitable for university chemistry, materials science and physics departments, research institutions, industrial laboratories, and industrial libraries.
eBook
Every molecule tells a story
\"Preface Everything that exists is made of atoms, and most of those substances contain groups of two or more of these bonded together to form molecules. Chemistry is the science of molecules. From cooking to medicine, from engineering to art, it is everywhere\"-- Provided by publisher.
Book
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur. Drug development involves assessment of absorption, distribution, metabolism and excretion (ADME) increasingly earlier in the discovery process, at a stage when considered compounds are numerous but access to the physical samples is limited. In that context, computer models constitute valid alternatives to experiments. Here, we present the new SwissADME web tool that gives free access to a pool of fast yet robust predictive models for physicochemical properties, pharmacokinetics, drug-likeness and medicinal chemistry friendliness, among which in-house proficient methods such as the BOILED-Egg, iLOGP and Bioavailability Radar. Easy efficient input and interpretation are ensured thanks to a user-friendly interface through the login-free website http://www.swissadme.ch. Specialists, but also nonexpert in cheminformatics or computational chemistry can predict rapidly key parameters for a collection of molecules to support their drug discovery endeavours.
Journal Article
Atoms and molecules : investigating the building blocks of matter
A look at various theories about atoms throughout history.
Book
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) development of sociality can be impaired. However, the molecular mechanism underlying NLGN3-mediated social development is unclear. Here, we identify non-canonical interactions between NLGN3 and protein tyrosine phosphatase δ (PTPδ) splice variants, competing with NRXN binding. NLGN3-PTPδ complex structure revealed a splicing-dependent interaction mode and competition mechanism between PTPδ and NRXNs. Mice carrying a NLGN3 mutation that selectively impairs NLGN3-NRXN interaction show increased sociability, whereas mice where the NLGN3-PTPδ interaction is impaired exhibit impaired social behavior and enhanced motor learning, with imbalance in excitatory/inhibitory synaptic protein expressions, as reported in the Nlgn3 R451C autism model. At neuronal level, the autism-related Nlgn3 R451C mutation causes selective impairment in the non-canonical pathway. Our findings suggest that canonical and non-canonical NLGN3 pathways compete and regulate the development of sociality.
Journal Article
Molecules
\"Molecules may be minuscule, but life wouldn't exist without them! This approachable look at an important chemistry topic takes young scientists on a tour of the world at the atomic level. They'll learn how atoms combine to form molecules and about some familiar and vital molecules, such as carbon dioxide. Thought-provoking fact boxes offer even more interesting information, while useful diagrams help learners visualize the amazing processes of nature\"-- Provided by publisher.
Book
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs. Targeting metabolic enzymes has been the focus of recent interest, but effective inhibitors have been difficult to identify. We describe a synthetic azetidine derivative, BRD4592, that kills Mycobacterium tuberculosis (Mtb) through allosteric inhibition of tryptophan synthase (TrpAB), a previously untargeted, highly allosterically regulated enzyme. BRD4592 binds at the TrpAB α-β-subunit interface and affects multiple steps in the enzyme's overall reaction, resulting in inhibition not easily overcome by changes in metabolic environment. We show that TrpAB is required for the survival of Mtb and Mycobacterium marinum in vivo and that this requirement may be independent of an adaptive immune response. This work highlights the effectiveness of allosteric inhibition for targeting proteins that are naturally highly dynamic and that are essential in vivo, despite their apparent dispensability under in vitro conditions, and suggests a framework for the discovery of a next generation of allosteric inhibitors.
Journal Article