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Monte Carlo Calculations in Nuclear Medicine (Second Edition)
The book provides a review of concepts and methodologies developed and adopted for quantitative imaging-guided radiation dosimetry calculations in targeted radionuclide. It also provides an overview of model design of anthropomorphic computational models and software packages developed for Monte Carlo-based dosimetry calculations.
eBook
A very stable genius : Donald J. Trump's testing of America
\"From Washington Post national investigative reporter Carol Leonnig and White House Bureau Chief Philip Rucker, both winners of the Pulitzer Prize, shocking new reporting on Donald Trump's unique presidency and its implications. Rucker and Leonnig have deep and unmatched sources throughout Washington, D.C., and for the past three years have chronicled in depth the ways President Donald Trump has reinvented the presidency in his own image, shaken foreign alliances and tested American institutions. It would be all too easy to mistake Trump's first term for pure chaos. But Leonnig and Rucker show that in fact there is a pattern and meaning to the daily disorder. Relying on scores of exclusive new interviews with first-hand witnesses and rigorous original reporting, the authors reveal the 45th President up close as he stares down impeachment. They take readers inside Robert Mueller's Russia investigation and the Trump legal team's scramble for survival, behind the curtains as the West Wing scurries to clean up the President's mistakes and into the room to witness Trump's interactions with foreign leaders and members of his Cabinet, and assess the consequences\"-- Provided by publisher.
Book
Perez & Brady's principles and practice of radiation oncology
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline's \"text-of-record,\" belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
eBook
Exonerated : the failed takedown of President Donald Trump by the swamp
\"[This book] reveals how Deep State actors relied on a cynical plug-and-play template to manufacture the now-discredited Russiagate scandal ... [The author] exposes who masterminded the dangerous playbook to take down Trump, their motives, and how a plan filled with faked allegations backfired--forcing investigators to up the ante and hide their missteps and half-truths in a desperate effort to prove a collusion case that never happened. The result? The misguided multimillion Mueller investigation that tore the nation apart, tried to destabilize the presidency and led, as the world now knows, to nowhere!\"--Dust jacket flap.
Book
Comparative dosimetry of radon in mines and homes
Studies of underground miners have provided a wealth of data about the risk of lung cancer from exposure to radon's progeny elements, but the application of the miner data to the home environment is not straightforward.In Comparative Dosimetry of Radon in Mines and Homes, an expert committee uses a new dosimetric model to extrapolate to the home environment the risk relationships found in the miner studies. Important new scaling factors are developed for applying risk estimates based on miner data to men, women, and children in domestic environments. The book includes discussions of radon dosimetry and the uncertainties concerning other risk factors such as age and smoking habits.The book also contains a thorough technical discussion of the characteristics of radioactive aerosols in domestic environments, the dose of inhaled radon progeny to different age groups, identification of respiratory tract cells at the greatest risk of carcinogenesis, and a complete description of the new lung dose model being developed by the International Commission on Radiological Protection as modified by this committee.
eBook
Radiation Dose Reconstruction for Epidemiologic Uses
Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation.
Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation.
Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume:
Provides an overview of the basic requirements and technical aspects of dose reconstruction.
Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere.
Explores the potential benefits and limitations of biological markers.
Discusses how to establish the \"source term\"-that is, to determine what was released.
Explores methods for identifying the environmental pathways by which radiation reaches the body.
Offers details on three major categories of dose assessment.
eBook
Mueller Matrix Associated with an Arbitrary 4×4 Real Matrix. The Effective Component of a Mueller Matrix
Due to the limited accuracy of experimental data, Mueller polarimetry can produce real 4×4 matrices that fail to meet required covariance or passivity conditions. A general and simple procedure to convert any real 4×4 matrix into a valid Mueller matrix by adding a portion of polarimetric white noise is presented. This approach provides deeper insight into the structure of Mueller matrices and has a subtle relation to the effective component of the Mueller matrix, which is defined through the subtraction of the fully random component of the characteristic decomposition. Up to a scale coefficient determined by the third index of polarimetric purity of the original Mueller matrix, the effective component retains complete information on the polarimetric anisotropies.
Journal Article
Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy
Local blood flow control within the central nervous system (CNS) is critical to proper function and is dependent on coordination between neurons, glia, and blood vessels. Macroglia, such as astrocytes and Müller cells, contribute to this neurovascular unit within the brain and retina, respectively. This study explored the role of microglia, the innate immune cell of the CNS, in retinal vasoregulation, and highlights changes during early diabetes. Structurally, microglia were found to contact retinal capillaries and neuronal synapses. In the brain and retinal explants, the addition of fractalkine, the sole ligand for monocyte receptor Cx3cr1, resulted in capillary constriction at regions of microglial contact. This vascular regulation was dependent on microglial Cx3cr1 involvement, since genetic and pharmacological inhibition of Cx3cr1 abolished fractalkine-induced constriction. Analysis of the microglial transcriptome identified several vasoactive genes, including angiotensinogen, a constituent of the renin-angiotensin system (RAS). Subsequent functional analysis showed that RAS blockade via candesartan abolished microglial-induced capillary constriction. Microglial regulation was explored in a rat streptozotocin (STZ) model of diabetic retinopathy. Retinal blood flow was reduced after 4 wk due to reduced capillary diameter and this was coincident with increased microglial association. Functional assessment showed loss of microglial–capillary response in STZ-treated animals and transcriptome analysis showed evidence of RAS pathway dysregulation in microglia. While candesartan treatment reversed capillary constriction in STZ-treated animals, blood flow remained decreased likely due to dilation of larger vessels. This work shows microglia actively participate in the neurovascular unit, with aberrant microglial–vascular function possibly contributing to the early vascular compromise during diabetic retinopathy.
Journal Article