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This study retrospectively collected clinical data from 480 patients with connective tissue diseases (CTDs) at Nanjing First Hospital between August 2019 and December 2023 to develop and validate a multi-classification machine learning (ML) model for assessing depression risk. Addressing the limitations of traditional assessment tools, six ML models were constructed using univariate analysis and the LASSO algorithm, with the categorical boosting (Catboost) model emerging as the best performer, demonstrating strong predictive ability across different depression severity levels (none_F1 = 0.879, mild_F1 = 0.627, moderate and severe_F1 = 0.588). Additionally, the study provided an interpretation of the best-performing model using SHAP and developed a user-friendly R Shiny application ( https://macnomogram.shinyapps.io/Catboost/ ) to facilitate clinical use. The findings suggest that the Catboost model represents a significant advancement in assessing depression risk among CTD patients, highlighting the potential of ML in enhancing mental health management for this patient population.

Quantum machine learning is a promising application of quantum computing for data classification. However, most of the previous research focused on binary classification, and there are few studies on multi-classification. The major challenge comes from the limitations of near-term quantum devices on the number of qubits and the size of quantum circuits. In this paper, we propose a hybrid quantum neural network to implement multi-classification of a real-world dataset. We use an average pooling downsampling strategy to reduce the dimensionality of samples, and we design a ladder-like parameterized quantum circuit to disentangle the input states. Besides this, we adopt an all-qubit multi-observable measurement strategy to capture sufficient hidden information from the quantum system. The experimental results show that our algorithm outperforms the classical neural network and performs especially well on different multi-class datasets, which provides some enlightenment for the application of quantum computing to real-world data on near-term quantum processors.

The Internet of Things (IoT) is prone to malware assaults due to its simple installation and autonomous operating qualities. IoT devices have become the most tempting targets of malware due to well-known vulnerabilities such as weak, guessable, or hard-coded passwords, a lack of secure update procedures, and unsecured network connections. Traditional static IoT malware detection and analysis methods have been shown to be unsatisfactory solutions to understanding IoT malware behavior for mitigation and prevention. Deep learning models have made huge strides in the realm of cybersecurity in recent years, thanks to their tremendous data mining, learning, and expression capabilities, thus easing the burden on malware analysts. In this context, a novel detection and multi-classification vision-based approach for IoT-malware is proposed. This approach makes use of the benefits of deep transfer learning methodology and incorporates the fine-tuning method and various ensembling strategies to increase detection and classification performance without having to develop the training models from scratch. It adopts the fusion of 3 CNNs, ResNet18, MobileNetV2, and DenseNet161, by using the random forest voting strategy. Experiments are carried out using a publicly available dataset, MaleVis, to assess and validate the suggested approach. MaleVis contains 14,226 RGB converted images representing 25 malware classes and one benign class. The obtained findings show that our suggested approach outperforms the existing state-of-the-art solutions in terms of detection and classification performance; it achieves a precision of 98.74%, recall of 98.67%, a specificity of 98.79%, F1-score of 98.70%, MCC of 98.65%, an accuracy of 98.68%, and an average processing time per malware classification of 672 ms.

This paper proposes a human activity recognition (HAR) method for frequency-modulated continuous wave (FMCW) radar sensors. The method utilizes a multi-domain feature attention fusion network (MFAFN) model that addresses the limitation of relying on a single range or velocity feature to describe human activity. Specifically, the network fuses time-Doppler (TD) and time-range (TR) maps of human activities, resulting in a more comprehensive representation of the activities being performed. In the feature fusion phase, the multi-feature attention fusion module (MAFM) combines features of different depth levels by introducing a channel attention mechanism. Additionally, a multi-classification focus loss (MFL) function is applied to classify confusable samples. The experimental results demonstrate that the proposed method achieves 97.58% recognition accuracy on the dataset provided by the University of Glasgow, UK. Compared to existing HAR methods for the same dataset, the proposed method showed an improvement of about 0.9–5.5%, especially in the classification of confusable activities, showing an improvement of up to 18.33%.

Drift is an important issue that impairs the reliability of sensors, especially in gas sensors. The conventional method usually adopts the reference gas to compensate for the drift. However, its classification accuracy is not high. We propose a supervised learning algorithm that is based on multi-classifier integration for drift compensation in this paper, which incorporates drift compensation into the classification process, motivated by the fact that the goal of drift compensation is to improve the classification performance. In our method, with the obtained characteristics of sensors and the advantage of Support Vector Machine (SVM) in few-shot classification, the improved Long Shot Term Memory (LSTM) is integrated to build the multi-class classifier model. We tested the proposed approach on the publicly available time series dataset that was collected over three years by the metal-oxide gas sensors. The results clearly indicate the superiority of multiple classifier approach, which achieves higher classification accuracy as compared with different approaches during testing period with an ensemble of classifiers in the presence of sensor drift over time.

Background Quality assurance (QA) of patient‐specific treatment plans for intensity‐modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) necessitates prior validation. However, the standard methodology exhibits deficiencies and lacks sensitivity in the analysis of positional dose distribution data, leading to difficulties in accurately identifying reasons for plan verification failure. This issue complicates and impedes the efficiency of QA tasks. Purpose The primary aim of this research is to utilize deep learning algorithms for the extraction of 3D dose distribution maps and the creation of a predictive model for error classification across multiple machine models, treatment methodologies, and tumor locations. Method We devised five categories of validation plans (normal, gantry error, collimator error, couch error, and dose error), conforming to tolerance limits of different accuracy levels and employing 3D dose distribution data from a sample of 94 tumor patients. A CNN model was then constructed to predict the diverse error types, with predictions compared against the gamma pass rate (GPR) standard employing distinct thresholds (3%, 3 mm; 3%, 2 mm; 2%, 2 mm) to evaluate the model's performance. Furthermore, we appraised the model's robustness by assessing its functionality across diverse accelerators. Results The accuracy, precision, recall, and F1 scores of CNN model performance were 0.907, 0.925, 0.907, and 0.908, respectively. Meanwhile, the performance on another device is 0.900, 0.918, 0.900, and 0.898. In addition, compared to the GPR method, the CNN model achieved better results in predicting different types of errors. Conclusion When juxtaposed with the GPR methodology, the CNN model exhibits superior predictive capability for classification in the validation of the radiation therapy plan on different devices. By using this model, the plan validation failures can be detected more rapidly and efficiently, minimizing the time required for QA tasks and serving as a valuable adjunct to overcome the constraints of the GPR method.

Background: Breast cancers are heterogeneous in nature, including many molecular subtypes, each displaying varying characteristics in clinical outcomes as well as in responses to treatments. Subtyping requires absolute precision for the application of precision medicine; however, this is not an easy task, given the dimensionality as well as noise in miRNA expression profiles. Even though miRNAs display potential as a biological marker for subtyping breast cancers, feature selection and optimizing learning algorithms would help harness their potential as a diagnostic tool. Methods: We propose the Adaptive Hill Climbing Artificial Lemming Algorithm (AHALA), a hybrid optimization framework that integrates the global search capability of the Artificial Lemming Algorithm with an adaptive hill-climbing local search strategy. Low-variance filtering and differential gene expression analysis were first applied to reduce dimensionality and enhance biological relevance. AHALA was then used to optimize deep neural network hyperparameters for miRNA-based multi-class breast cancer subtype classification. The method was validated using TCGA breast cancer miRNA expression data and benchmarked against state-of-the-art optimization algorithms using the CEC2021 test suite. Results: AHALA had a high classification performance measure for each type of breast cancer with a mean accuracy of 95.74%, precision of 95.98%, recall of 95.74%, F1 measure of 95.74%, and AUC value of 0.9682. The new algorithm had superior convergence and significance compared with other optimization algorithms. Feature selection revealed miRNAs that belong to each subtype, such as hsa-miR-190b, hsa-miR-429, hsa-miR-505-3p, hsa-miR-3614-5p, and hsa-miR-935. Conclusions: The AHALA framework offers a potent and efficient method of performing miRNA-based subtyping of breast cancer that integrates global exploration and local search to its advantage. Its high level of classification, stability, and ability to identify biologically important biomarkers mark this method as promising.

Background Premature ventricular contraction (PVC) is a type of cardiac arrhythmia that originates from ectopic pacemaker in the ventricles. The localization of the origin of PVC is essential for successful catheter ablation. However, most studies on non-invasive PVC localization focus on elaborate localization in specific regions of the ventricle. This study aims to propose a machine learning algorithm based on 12-lead electrocardiogram (ECG) data that can improve the accuracy of PVC localization in the whole ventricle. Methods We collected 12-lead ECG data from 249 patients with spontaneous or pacing-induced PVCs. The ventricle was divided into 11 segments. In this paper, we propose a machine learning method consisting of two consecutive classification steps. In the first classification step, each PVC beat was labeled to one of the 11 ventricular segments using six features, including a newly proposed morphological feature called “Peak_index.” Four machine learning methods were tested for comparative multi-classification performance and the best classifier result was kept to the next step. In the second classification step, a binary classifier was trained using a smaller combination of features to further differentiate segments that are easily confused. Results The Peak_index as a proposed new classification feature combined with other features is suitable for whole ventricle classification by machine learning methods. The test accuracy of the first classification reached 75.87%. It is shown that a second classification for confusable categories can improve the classification results. After the second classification, the test accuracy reached 76.84%, and when a sample classified into adjacent segments was considered correct, the test “rank accuracy” was improved to 93.49%. The binary classification corrected 10% of the confused samples. Conclusion This paper proposes a “two-step classification” method to localize the origin of PVC beats into the 11 regions of the ventricle using non-invasive 12-lead ECG. It is expected to be a promising technique to be used in clinical settings to help guide ablation procedures.

The purpose of this research is to propose a new method for identifying diabetic retinopathy using retinal fundus images. Currently, identifying diabetic retinopathy from computerized fundus images is a challenging task in medical image processing and requires new strategies to be developed. The manual analysis of the retinal fundus is time-consuming and requires a significant amount of skill. To assist clinicians, this research develops a graphical user interface that integrates imaging algorithms to assess whether the patient’s fundus image is affected by diabetic retinopathy. The diagnosis is made using a deep neural network, specifically the Resnet152-V2, which has been shown to have 100% accuracy in all evaluation criteria including accuracy, recall, precision, and F1 Score. The severity of the disease is displayed on the graphical user interface and the patient’s information is stored in a local database. This proposed method can also be used by ophthalmologists as a backup option to support in disease detection, reducing the necessary processing time.

The impact of communication through social media is currently considered a significant social issue. This issue can lead to inappropriate behavior using social media, which is referred to as cyberbullying. Automated systems are capable of efficiently identifying cyberbullying and performing sentiment analysis on social media platforms. This study focuses on enhancing a system to detect six types of cyberbullying tweets. Employing multi-classification algorithms on a cyberbullying dataset, our approach achieved high accuracy, particularly with the TF-IDF (bigram) feature extraction. Our experiment achieved high performance compared with that stated for previous experiments on the same dataset. Two ensemble machine learning methods, employing the N-gram with TF-IDF feature-extraction technique, demonstrated superior performance in classification. Three popular multi-classification algorithms: Decision Trees, Random Forest, and XGBoost, were combined into two varied ensemble methods separately. These ensemble classifiers demonstrated superior performance compared to traditional machine learning classifier models. The stacking classifier reached 90.71% accuracy and the voting classifier 90.44%. The results of the experiments showed that the framework can detect six different types of cyberbullying more efficiently, with an accuracy rate of 0.9071.