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Mild hyperthermia can locally enhance permeability of the blood-tumor barrier in brain tumors, improving delivery of antitumor nanodrugs. However, a clinical transcranial focused ultrasound (FUS) system does not provide this modality yet. The study aimed at the development of the transcranial FUS technique dedicated for large-volume mild hyperthermia in the brain. Acoustic pressure, multiple-foci, temperature and thermal dose induced by FUS were simulated in the brain through the skull. A 1-MHz, 114-element, spherical helmet transducer was fabricated to verify large-volume hyperthermia in the phantom. The simulated results showed that two foci were simultaneously formed at (2, 0, 0) and (−2, 0, 0) and at (0, 2, 0) and (0, −2, 0), using the phases of focusing pattern 1 and the phases of focusing pattern 2, respectively. Switching two focusing patterns at 5 Hz produced a hyperthermic zone with an ellipsoid of 7 mm × 6 mm × 11 mm in the brain and the temperature was 41–45 °C in the ellipsoid as the maximum intensity was 150 W/cm2 and sonication time was 3 min. The phased array driven by switching two mode phases generated a 41 °C-contour region of 10 ± 1 mm × 8 ± 2 mm × 13 ± 2 mm in the phantom after 3-min sonication. Therefore, we have demonstrated our developed FUS technique for large-volume mild hyperthermia.

We present a scoring-based genetic algorithm (SBGA) for wavefront shaping to optimize multiple objectives at a time. The algorithm is able to find one feasible solution despite having to optimize multiple objectives. We employ the algorithm to generate multiple focus points simultaneously and allocate their intensities as desired. We then introduce a third objective to confine light focusing only to desired targets and prevent irradiation in neighboring regions. Through simulations and experiments, we demonstrate the algorithm’s ease of implementation and flexibility to control the search direction. This algorithm can potentially be applied to improve biomedical imaging, optogenetics, and optical trapping.

Chinese has the comparative morpheme and the positive morpheme, both of which project in syntax. The covert comparative morpheme is the covert allomorph of the comparative morpheme bĭjiào 'more'. The covert bĭjiào 'more' can only occur in a comparative construction where an overt standard of comparison is syntactically available, but the overt one occurs in a comparative construction where an overt standard of comparison is syntactically unavailable. The positive morpheme also has two allomorphs. One is the unstressed hĕcn 'HEN' and the other is its covert counterpart. The covert one can only occur in a focus sensitive domain where the bare gradable adjective is focus-anchored, but the overt one occurs elsewhere. The covert allomorph, regardless of whether it is the comparative or the positive morpheme, is used to avoid violating the Constraint on Multiple Foci. Accordingly, the proposal of the comparative morpheme and the proposal of the positive morpheme can reinforce each other by establishing a theoretical relationship through the Nonhead Stress rule and the Constraint on Multiple Foci.

Background The aim of this study was the evaluation of breast MRI in determining the size and focality of invasive non-metastatic breast cancers. Methods The prospective, single-centre study conducted in 2015 compared preoperative MRI with histological analysis of mastectomy. Results One hundred one mastectomies from 98 patients were extensively analysed. The rates of false-positive and false-negative MRI were 2 and 4% respectively. The sensitivity of breast MRI was 84.7% for the detection of all invasive foci, 69% for single foci and 65.7% for multiple foci. In the evaluation of tumour size, the Spearman rank correlation coefficient r between the sizes obtained by MRI and histology was 0.62. The MRI-based prediction of a complete response to neoadjuvant chemotherapy was 75%. Discussion MRI exhibits high sensitivity in the detection of invasive breast cancers. False positives were linked to the inflammatory nature of the tumour bed. False negatives were associated with small or low-grade tumours and their retro-areolar location. The size of T1 tumours was overestimated by an average of 7%, but MRI was the most efficient procedure. The sensitivity of MRI for the diagnosis of unifocal tumours was higher than that for multifocal sites. Our study confirmed the positive contribution of preoperative MRI for invasive lobular carcinomas and complete response predictions after neoadjuvant chemotherapy.

Background and Clinical Significance: Pellagra is caused by a chronic deficiency of niacin (vitamin B3 or nicotinic acid): it is rare in developed countries, where the major risk factors are chronic alcoholism and intestinal malabsorption. Although it typically presents three main symptoms, dermatitis, diarrhea, and dementia, some cases do not show these classic symptoms. Case Presentation: We report a case of a malnourished patient with seizure and multiple cerebrovascular foci, in whom a postmortem autopsy revealed the findings of pellagra. The patient had atypical symptoms of seizure as pellagra and the multiple cerebrovascular lesions, which made the diagnosis difficult. Conclusions: The aim of this paper is to recognize the importance of suspecting pellagra as a treatable disease, especially when patients with eating disorder present atypical symptoms.

In this paper, we develop a criterion to calculate the multiplicity of a multiple focus for general predator-prey systems. As applications of this criterion, we calculate the largest multiplicity of a multiple focus in a predator-prey system with nonmonotonic functional response$p(x) = {\\frac{x}{ax^2+bx+1}}$studied by Zhu, Campbell, and Wolkowicz [SIAM J. Appl. Math., 63 (2002), pp. 636-682] and prove that the degenerate Hopf bifurcation is of codimension two. Furthermore, we show that there exist parameter values for which this system has a unique positive hyperbolic stable equilibrium and exactly two limit cycles, the inner one unstable and outer one stable. Numerical simulations for the existence of the two limit cycles bifurcated from the multiple focus are also given in support of the criterion.

Objective To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. Methods A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. Results A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207), S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. Conclusions LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765.

Purpose Multiple punctate echogenic foci (MPEF) on thyroid ultrasonography reflects psammoma bodies in papillary thyroid carcinomas. However, MPEF is also observed in benign thyroid lesions. The aim of this study was to determine the origin of MPEF in patients with benign thyroid lesions. Methods We enrolled 26 patients with Graves’ disease (GD) and 24 with follicular nodular disease (FND) who exhibited MPEF and underwent surgery. As controls, we enrolled 40 patients with GD and 32 with FND, but without MPEF, who underwent surgery. Results MPEF was observed in both lobes in 80.8% of GDs with MPEF, but was limited to a single lobe in the remaining cases. MPEF was diffusely distributed in 72.3% of the cases and focally distributed in the remaining cases. On ultrasonography, most (92.3%) FNDs with MPEF were solid lesions, and seven nodules (26.9%) were interpreted as intermediate suspicion and their frequencies were higher than in those without MPEF ( p  < 0.01). Microscopically, calcium oxalate (CaOx) crystals were observed more frequently in GDs and FNDs with MPEF (100% and 88.5%, respectively) than in those without MPEF ( p  < 0.001). These differences were particularly significant for CaOx crystals > 100 μm. In GD cases, large CaOx crystals were observed more frequently in the lobes with MPEF than in those without ( p  < 0.05). No psammoma bodies were present in any of the cases. Conclusion Appearance of MPEF in GDs and FNDs is not because of psammoma bodies; it is attributable to CaOx crystals larger than 100 μm. Therefore, MPEF is not an indicator of malignancy.

The use of MRI to assess the extent of breast disease is gaining increasing popularity with the subsequent detection of multiple invasive foci within the breast that had not been identified on previous standard mammography and ultrasonography. What impact this has on subsequent surgical management and ultimately disease-free survival remains a controversial topic. Should histologically confirmed multiple foci of invasive disease within a breast steer the surgical management towards mastectomy, or is there a role in select patients for breast conserving surgery, even if two or more incisions are required? This review considers the evidence for how MRI affects the mastectomy rate and compares this to surgical outcomes for breast conserving surgery in the presence of multiple invasive foci.