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"Muscles Juvenile literature."
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20 fun facts about the muscular system
\"Muscles do far more than help us lift heavy things off the ground. Muscles make the heart work well and move food through the stomach. They allow us to walk, swim, and even draw! In the fun fact file format, this book introduces readers to the most interesting aspects of the muscular system, including information from the science curriculum, through engaging and sometimes gross tidbits!\"-- Provided by publisher.
Book
Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review
Background
Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and complex clinical manifestation, misdiagnosis often occurs in clinical practice.
Case presentation
A 42-year-old man with multiple pedunculated colorectal polyps and concomitant rectal adenocarcinoma was admitted to our hospital. His mother had died of colon cancer. He was diagnosed with familial adenomatous polyposis (FAP) and underwent total proctocolectomy and ileal pouch anal anastomosis. Two polyps were selected for pathological examination. One polyp had cystically dilated glands with slight dysplasia. The other polyp displayed severe dysplasia and was diagnosed as adenoma. Three years later, his 21-year-old son underwent a colonoscopy that revealed more than 50 pedunculated colorectal juvenile polyps. Both patients harbored a germline pathogenic mutation in
BMPR1A
. Endoscopic resection of all polyps was attempted but failed. Finally, the son received endoscopic resection of polyps in the rectum and sigmoid colon, and laparoscopic subtotal colectomy. Ten polyps were selected for pathological examination. All were revealed to be typical juvenile polyps, with cystically dilated glands filled with mucus. Thus, the diagnosis of JPS was confirmed in the son. A review of the literatures revealed that patients with JPS can sometimes have adenomatous change. Most polyps in patients with JPS are benign hamartomatous polyps with no dysplasia. A review of 767 colorectal JPS polyps demonstrated that 8.5% of the polyps contained mild to moderate dysplasia, and only 0.3% had severe dysplasia or cancer. It is difficult to differentiate juvenile polyps with dysplasia from adenoma, which could explain why juvenile polyps have been reported to have adenomatous changes in patients with JPS. Therefore, patients with JPS, especially those with concomitant dysplasia and adenocarcinoma, might be easily diagnosed as FAP in clinical practice.
Conclusions
Juvenile polyp with dysplasia is often diagnosed as adenoma, which might lead to the misdiagnosis of JPS as FAP. The differential diagnosis of JPS versus FAP, should be based on comprehensive evaluation of clinical presentation, endoscopic appearance and genetic investigations; not on the presence or absence of adenoma.
Journal Article
Juvenile polymyositis associated with ureteral necrosis: a diagnostic and therapeutic dilemma—case report and review of the literature
We describe an 11-year-old girl, diagnosed with juvenile polymyositis (JPM), who developed right ureteral obstruction secondary to necrosis. We emphasize the dilemmas regarding optimal timing for surgical intervention and medical treatment. Vascular involvement, which could be a part of juvenile dermatomyositis, may also be a feature of JPM. We discuss the association between vasculopathy and ureteral necrosis and review the literature regarding similar conditions. Whether the ureteral necrosis is a specific feature of vasculopathy, or a result of visceral calcinosis, needs to be further explored.
Journal Article
Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature
Juvenile hemochromatosis (JH) is a severe form of hemochromatosis, which involves rapid iron overload and leads to organ damage, typically before the age of 30. We report a single case of a 25-year-old man suffering from juvenile hemochromatosis, with aggressive clinical manifestations, typically characterized by transaminasemia and progressive erectile dysfunction, due to hypogonadotropic hypogonadism. The clinical case appears interesting, as the patient also had secondary osteoporosis accompanied by increased bone resorption, which prevalently affected trabecular bone. Approximately 6 months after normalization of serum ferritin levels was achieved by frequent phlebotomies, he became eugonadal and bone mineral density of the lumbar spine increased. Our observations suggest that osteoporosis might occur in the state of JH even at a young age, mainly due to the deprivation of sex steroids and the direct tissue toxicity of iron.
Journal Article
My muscles
\"A boy named Lucas has injured his calf muscle in PE class. Lucas and his classmate Mia discuss the body's muscles\"-- Provided by publisher.
Book
Constipation and incontinence in childhood: two sides of the same coin?
FACTORS AFFECTING DELAY IN ACQUISITION OF CONTINENCE The sensation arising from bladder or rectal filling is slight or absent in neuropathic conditions such as neural tube defects, spinal injury or compression. [...]diligence is essential in examination the lower spine and sacrum together with the ankle reflexes for even subtle evidence of spinal dysraphism. 3, 4 Anything that disturbs learning of the link between the perception of bladder/rectal sensation and the social need to use the pot or lavatory is likely to delay acquisition of continence. A similar situation occurs with children who infrequently empty their bladders and appear to be unaware of bladder sensation until it reaches a critical stage and precipitate voiding does not allow them to reach the lavatory in time. Because wetting and faecal incontinence lead to peer and parental adverse pressure, the stress related to this may encourage the child to escape into dissociation and denial thus reducing their vigilance for sensations coming from these troubling areas.
Journal Article
Understanding muscles and the skeleton
Explains the structure and functioning of our muscles and skeleton.
Book
The science of the skeleton and muscles
Fun graphics and easy-to-comprehend language teach young readers how bones and muscles work together to support the human body and enable its many movements. Includes glossary and flowcharts that emphasize key concepts.
Book