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\"Living in a quiet seaside village with their overprotective mother, teenaged sisters Calliope, Clio, Melpomene, Terpsichore, and Thalia are talented performers with no audience. If Calli had her way, she'd pursue her dream of writing epic stories in the city of Thebes. But family comes first, and as the eldest, she'd never leave her beloved sisters behind. Then, following a disastrous public music performance, their mother reveals a shocking secret: she is Mnemosyne, the Goddess of Memory, and for nearly two decades, she's been on the run from the gods of Mount Olympus, desperate to keep her daughters safe from their machinations. Before she can share more, she is kidnapped . . . and though the girls don't know it yet, the villain pulling the strings is none other than Hades, fiery God of the Underworld. Under Calli's leadership, the sisters embark on a journey to save their mother and to learn more about their own divine origins. But the path ahead is filled with mythical trials and tribulations, and they'll need to rely on both their individual talents and the strength of their sisterhood to ensure that they ascend from \"zeroes\" to \"heroes\"--or more accurately, heroines.\"-- Provided by publisher.

Imaging spectrometry from aerial or spaceborne platforms, also known as hyperspectral remote sensing, provides dense sampled and fine structured spectral information for each image pixel, allowing the user to identify and characterize Earth surface materials such as minerals in rocks and soils, vegetation types and stress indicators, and water constituents. The recently launched DLR Earth Sensing Imaging Spectrometer (DESIS) installed on the International Space Station (ISS) closes the long-term gap of sparsely available spaceborne imaging spectrometry data and will be part of the upcoming fleet of such new instruments in orbit. DESIS measures in the spectral range from 400 and 1000 nm with a spectral sampling distance of 2.55 nm and a Full Width Half Maximum (FWHM) of about 3.5 nm. The ground sample distance is 30 m with 1024 pixels across track. In this article, a detailed review is given on the applicability of DESIS data based on the specifics of the instrument, the characteristics of the ISS orbit, and the methods applied to generate products. The various DESIS data products available for users are described with the focus on specific processing steps. The results of the data quality and product validation studies show that top-of-atmosphere radiance, geometrically corrected, and bottom-of-atmosphere reflectance products meet the mission requirements. The limitations of the DESIS data products are also subject to a critical examination.

Whether for identification and characterization of materials or for monitoring of the environment, space-based hyperspectral instruments are very useful. Hyperspectral instruments measure several dozens up to hundreds of spectral bands. These data help to reconstruct the spectral properties like reflectance or emission of Earth surface or the absorption of the atmosphere, and to identify constituents on land, water, and in the atmosphere. There are a lot of possible applications, from vegetation and water quality up to greenhouse gas monitoring. But the actual number of hyperspectral space-based missions or hyperspectral space-based data is limited. This will be changed in the next years by different missions. The German Aerospace Center (DLR) Earth Sensing Imaging Spectrometer (DESIS) is one of the new currently existing space-based hyperspectral instruments, launched in 2018 and ready to reduce the gap of space-born hyperspectral data. The instrument is operating onboard the International Space Station, using the Multi-User System for Earth Sensing (MUSES) platform. The instrument has 235 spectral bands in the wavelength range from visible (400 nm) to near-infrared (1000 nm), which results in a 2.5 nm spectral sampling distance and a ground sampling distance of 30 m from 400 km orbit of the International Space Station. In this article, the design of the instrument will be described.

Background Bleomycin (BLM)-induced lung injury is characterized by mixed histopathologic changes with inflammation and fibrosis, such as observed in human patients with bronchopulmonary dysplasia, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. Although no curative therapies for these lung diseases exist, stem cell therapy has emerged as a potential therapeutic option. Multilineage-differentiating stress-enduring (Muse) cells are endogenous pluripotent- and macrophage-like stem cells distributed in various adult and fetal tissues as stage-specific embryonic antigen-3-positive cells. They selectively home to damaged tissue by sensing sphingosine-1-phosphate and replace the damaged/apoptotic cells by in vivo differentiation. Clinical trials for some human diseases suggest the safety and therapeutic efficacy of intravenously injected human leukocyte antigen-mismatched allogenic Muse cells from adult bone marrow (BM) without immunosuppressant. Here, we evaluated the therapeutic effects of human Muse cells from preterm and term umbilical cord (UC), and adult BM in a rat BLM-induced lung injury model. Methods Rats were endotracheally administered BLM to induce lung injury on day 0. On day 3, human preterm UC-Muse, term UC-Muse, or adult BM-Muse cells were administered intravenously without immunosuppressants, and rats were subjected to histopathologic analysis on day 21. Body weight, serum surfactant protein D (SP-D) levels, and oxygen saturation (SpO 2 ) were monitored. Histopathologic lung injury scoring by the Ashcroft and modified American Thoracic Society document scales, quantitative characterization of engrafted Muse cells, RNA sequencing analysis, and in vitro migration assay of infused Muse cells were performed. Results Rats administered preterm- and term-UC-Muse cells exhibited a significantly better recovery based on weight loss, serum SP-D levels, SpO 2 , and histopathologic lung injury scores, and a significantly higher rate of both Muse cell homing to the lung and alveolar marker expression (podoplanin and prosurfactant protein-C) than rats administered BM-Muse cells. Rats receiving preterm-UC-Muse cells showed statistically superior results to those receiving term-UC-Muse cells in many of the measures. These findings are thought to be due to higher expression of genes related to cell migration, lung differentiation, and cell adhesion. Conclusion Preterm UC-Muse cells deliver more efficient therapeutic effects than term UC- and BM-Muse cells for treating BLM-induced lung injury in a rat model.

As medical imaging enters its information era and presents rapidly increasing needs for big data analytics, robust pooling and harmonization of imaging data across diverse cohorts with varying acquisition protocols have become critical. We describe a comprehensive effort that merges and harmonizes a large-scale dataset of 10,477 structural brain MRI scans from participants without a known neurological or psychiatric disorder from 18 different studies that represent geographic diversity. We use this dataset and multi-atlas-based image processing methods to obtain a hierarchical partition of the brain from larger anatomical regions to individual cortical and deep structures and derive age trends of brain structure through the lifespan (3–96 years old). Critically, we present and validate a methodology for harmonizing this pooled dataset in the presence of nonlinear age trends. We provide a web-based visualization interface to generate and present the resulting age trends, enabling future studies of brain structure to compare their data with this reference of brain development and aging, and to examine deviations from ranges, potentially related to disease. •Multi-site harmonization method that pools volumetric data from 18 studies, controlling for nonlinear age effects.•Resulting dataset covers ages 3 to 96 and used to derive age trends of brain structure through the lifespan.•Interactive visualization tool provided for exploring age trends and comparing new data.

During the interval from September through early December 2005, the Hayabusa spacecraft was in close proximity to near-Earth asteroid 25143 Itokawa, and a variety of data were taken on its shape, mass, and surface topography as well as its mineralogic and elemental abundances. The asteroid's orthogonal axes are 535, 294, and 209 meters, the mass is 3.51 x 10¹⁰ kilograms, and the estimated bulk density is 1.9 ± 0.13 grams per cubic centimeter. The correspondence between the smooth areas on the surface (Muses Sea and Sagamihara) and the gravitationally low regions suggests mass movement and an effective resurfacing process by impact jolting. Itokawa is considered to be a rubble-pile body because of its low bulk density, high porosity, boulder-rich appearance, and shape. The existence of very large boulders and pillars suggests an early collisional breakup of a preexisting parent asteroid followed by a re-agglomeration into a rubble-pile object.

Purpose of Review In this review, we define health equity, disparities, and social determinants of health; the different components of digital health; the barriers to digital health equity; and cardiovascular digital health trials and possible solutions to improve health equity through digital health. Recent Findings Digital health interventions show incredible potential to improve cardiovascular diseases by obtaining longitudinal, continuous, and actionable patient data; increasing access to care; and by decreasing delivery barriers and cost. However, certain populations have experienced decreased access to digital health innovations and decreased representation in cardiovascular digital health trials. Summary Special efforts will need to be made to expand access to the different elements of digital health, ensuring that the digital divide does not exacerbate health disparities. As the expansion of digital health technologies continues, it is vital to increase representation of minoritized groups in all stages of the process: product development (needs findings and screening, concept generation, product creation, and testing), clinical research (pilot studies, feasibility studies, and randomized control trials), and finally health services deployment.

This series is dedicated to classical studies in general. The featured essays primarily examine topics relating to the ancient world from the fields of literary, visual, media, theatre, religious, and cultural studies. There is a particular emphasis on the application of modern theories, e.g. in the sphere of anthropology, performativity and narrativity; interdisciplinary comparisons; the mythical/ritual and iconic poetics of texts and images; and the reception of classical material in this context.

We found adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers. The cells are stress-tolerant and can be isolated from cultured skin fibroblasts or bone marrow stromal cells, or directly from bone marrow aspirates. These cells can self-renew; form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency; and can differentiate into endodermal, ectodermal, and mesodermal cells both in vitro and in vivo. When transplanted into immunodeficient mice by local or i.v. injection, the cells integrated into damaged skin, muscle, or liver and differentiated into cytokeratin 14-, dystrophin-, or albumin-positive cells in the respective tissues. Furthermore, they can be efficiently isolated as SSEA-3(+) cells. Unlike authentic ES cells, their proliferation activity is not very high and they do not form teratomas in immunodeficient mouse testes. Thus, nontumorigenic stem cells with the ability to generate the multiple cell types of the three germ layers can be obtained through easily accessible adult human mesenchymal cells without introducing exogenous genes. These unique cells will be beneficial for cell-based therapy and biomedical research.