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"Mutation"
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Mutants in nature
\"This photo-illustrated book for elementary readers describes the types of mutations that can happen to animals and plants. Highlights how outside forces or random genetic mishaps can cause extra or missing limbs, color variations such as albinism, and other abnormalities\"-- Provided by publisher.
Book
47; The Impact of a Funded, National, Molecular Testing Program for the Canadian Biliary Tract Cancer Population
Background Molecular testing to identify tumour biomarkers is recommended by all major treatment guidelines for biliary tract cancer (BTC) and is ideally performed early after diagnosis. Most second-line treatment options for BTC are only available through clinical trials where molecular testing is required for eligibility. Despite these recommendations, many Canadians cannot access molecular testing due to barriers including financial burdens, inadequate testing, and geographic inequities. Here, we present the impact of a funded, national, molecular testing program implemented by the Canadian Cholangiocarcinoma Collaborative (C3). Methods The C3 molecular testing program was active from July 1, 2024 to December 31, 2025, in partnership with the University Health Network Genome Diagnostics Laboratory (UHN-GDL) for Ontario patients, and OncoHelix for patients in all other Canadian provinces (excluding Quebec due to existing provincial funding). Patients were eligible if they had locally advanced or metastatic biliary tract cancer, had not previously undergone molecular testing, and were enrolled in the C3 Registry. Both patients and their treating physicians received a clinically certified molecular report detailing any clinically actionable mutations and therapeutic targets. Results As of December 31, 2025, >275 patients from eight provinces (ON, BC, AB, SK, MB, NS, NL, NB) received molecular testing from the C3 program and >120 physicians were engaged throughout the process. Genetic alterations were reported in close to 50% of the cases, of which 28% were Tier I (including FGFR2 fusions, IDH1 mutations, KRAS G12C) and 22% Tier 11/111 (including BRAF V600E, BRCA1/2, HER2, KRAS G12D mutations and MDM2 amplifications). Thirteen cases were presented at the C3 National Multidisciplinary Rounds. Conclusions In the absence of molecular testing, treatment options for advanced BTC are largely limited. Real-world evidence from the C3 molecular testing program will be analyzed to support efforts toward standardizing and publicly funding molecular testing tor BTC in Canada.
Journal Article
Secret weapons
The government has dispatched Amanda McKee - the technopath codenamed Livewire - to investigate the ruins of a secret facility formerly run by Toyo Harada, the most powerful telepath on Earth and her former mentor. In his quest for world betterment at any cost, Harada sought out and activated many potential psiots like himself. Those who survived, but whose powers he deemed to have no value to his cause, were hidden away at this installation. But Livewire, having studied Harada's greatest strengths and learned his deepest weaknesses, senses opportunity where he once saw failure. A young girl who can talk to birds... A boy who can make inanimate objects gently glow... To others, these are expensive disappointments. But, to Livewire, they are secret weapons...in need of a leader. Now, as a mechanized killer called Rex-O seeks to draw them out, Livewire and her new team of cadets will be forced to put their powers into action...in ways they never could have imagined
Book
Roadside picnic
Red Schuhart is a stalker, one of those misfits who are compelled, in spite of extreme danger, to venture illegally into the Zone to collect the mysterious artefacts that the alien visitors left scattered around. His life is dominated by the place and the thriving black market in the alien products. Even the nature of his mutant daughter has been determined by the Zone. And it is for her that he makes his last tragic foray into the hazardous and hostile territory.
Book
