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Nanotechnology promises to transform the materials of everyday life, leading to smaller and more powerful computers, more durable plastics and fabrics, cheap and effective water purification systems, more efficient solar panels and storage batteries, and medical devices capable of tracking down and killing cancer cells or treating neurological diseases. Policy analysts predict a radical change in the industrial sector; at present, the U.S. government spends nearly $2 billion annually on nanotechnology research and development. Yet the nanotechnology revolution is not straightforward. Enthusiasm about nanotechnology's future is tempered by recognition of the hurdles to its responsible development, including the capacity of government to support technological innovation and economic growth while also addressing potential environmental and public health impacts. This is the first volume to engage scholarly perspectives on environmental regulation in light of the challenges posed by nanotechnology. Contributors focus on the overarching lessons of decades of regulatory response, while posing a fundamental question: How can government regulatory systems satisfy the desire for scientific innovation while also taking into account the direct and indirect effects of 21st century emerging technologies, particularly in the face of scientific uncertainties? With perspectives from economics, history, philosophy, and public policy, this new resource illuminates the various challenges inherent in the development of nanotechnology and works towards a reconceptualization of government regulatory approaches.

Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems An indispensable compendium detailing the toxicology of nanoparticles with a focus on mechanisms, emerging issues, and new approaches Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems provides authoritative information on the toxicology of ultrafine and nanoparticulate matter that contaminate terrestrial or aquatic environments and present unique challenges in applied public health and toxicological research. Detailed chapters by a panel of world-renowned experts examine the complementary and dynamic interdependence of aquatic, terrestrial, and human systems and the toxicological impacts on exposure to engineered and manufactured nanoparticles and nanomaterials. Organized into four sections, the book opens with a thorough overview of the field, including known challenges and the necessity for current research activity. The second section describes terrestrial and aquatic systems and the ecotoxicological impact of nanomaterials, followed by critical analysis of the many human health effects of nanomaterials. The book concludes with an in-depth discussion of current gaps in knowledge, future directions, new approach methodologies, alternatives to animal models, and the emerging environmental threat from nanoplastics. Presenting case exemplars of the ecotoxicological impact of nanoparticles in aquatic and terrestrial systems, this important resource: * Presents in-depth coverage of ecosafety, environmental behavior, fate and transport, interactive effects with other contaminants, and current challenges in soil nano-ecotoxicology * Addresses rising concerns regarding air pollution and neurological disorders, and the roles played by the gastrointestinal system, the mucosal microbiome, and the immunotoxicology and vasculotoxicity of metal-based nanoparticles * Provides detailed coverage of nanomaterial health effects from both animal and in vitro models, including the gut microbiome, innate immunity, neurological and cardiovascular impacts, mechanisms of action, and hazard characterization * Analyzes key topics in ecological nanotoxicology such as environmental micro- and nano-plastic pollution and applied risk assessment Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems is essential reading for toxicologists, applied biologists, ecotoxicologists, research scientists, medical professionals, regulators, and advanced students in fields such as public health, environmental ecotoxicology and medicine, immunotoxicology, neurotoxicology, cardiovascular and systems biology, hazard identification, and risk assessment.

In materials science, “green” synthesis has gained extensive attention as a reliable, sustainable, and eco-friendly protocol for synthesizing a wide range of materials/nanomaterials including metal/metal oxides nanomaterials, hybrid materials, and bioinspired materials. As such, green synthesis is regarded as an important tool to reduce the destructive effects associated with the traditional methods of synthesis for nanoparticles commonly utilized in laboratory and industry. In this review, we summarized the fundamental processes and mechanisms of “green” synthesis approaches, especially for metal and metal oxide [e.g., gold (Au), silver (Ag), copper oxide (CuO), and zinc oxide (ZnO)] nanoparticles using natural extracts. Importantly, we explored the role of biological components, essential phytochemicals (e.g., flavonoids, alkaloids, terpenoids, amides, and aldehydes) as reducing agents and solvent systems. The stability/toxicity of nanoparticles and the associated surface engineering techniques for achieving biocompatibility are also discussed. Finally, we covered applications of such synthesized products to environmental remediation in terms of antimicrobial activity, catalytic activity, removal of pollutants dyes, and heavy metal ion sensing.

Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge by examining, through a scoping review of the current literature, the effects of nanoparticles on human health and the environment. We searched relevant databases including Medline, Web of Science, ScienceDirect, Scopus, CINAHL, Embase, and SAGE journals, as well as Google, Google Scholar, and grey literature from June 2021 to July 2021. After removing duplicate articles, the title and abstracts of 1495 articles were first screened followed by the full-texts of 249 studies, and this resulted in the inclusion of 117 studies in the presented review. In this contribution we conclude that while nanoparticles offer distinct benefits in a range of applications, they pose significant threats to humans and the environment. Using several biological models and biomarkers, the included studies revealed the toxic effects of nanoparticles (mainly zinc oxide, silicon dioxide, titanium dioxide, silver, and carbon nanotubes) to include cell death, production of oxidative stress, DNA damage, apoptosis, and induction of inflammatory responses. Most of the included studies (65.81%) investigated inorganic-based nanoparticles. In terms of biomarkers, most studies (76.9%) used immortalised cell lines, whiles 18.8% used primary cells as the biomarker for assessing human health effect of nanoparticles. Biomarkers that were used for assessing environmental impact of nanoparticles included soil samples and soybean seeds, zebrafish larvae, fish, and Daphnia magna neonates. From the studies included in this work the United States recorded the highest number of publications ( n  = 30, 25.64%), followed by China, India, and Saudi Arabia recording the same number of publications ( n  = 8 each), with 95.75% of the studies published from the year 2009. The majority of the included studies (93.16%) assessed impact of nanoparticles on human health, and 95.7% used experimental study design. This shows a clear gap exists in examining the impact of nanoparticles on the environment. Highlights • While nanoparticles are beneficial in a range of applications, they pose significant threats to humans and the environment. • Immortalised cell lines are mostly used as biomarkers to assess human health effect of nanoparticles. • Biomarkers such as soil samples and zebrafish larvae are used to investigate the environmental effect of nanoparticles. • This work has revealed the toxic effects of nanoparticles to include production of oxidative stress, DNA damage, apoptosis, cell death, and induction of inflammatory responses.

Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be taken up by aquatic organism as well as by mammals. Upon uptake, micro- and nanoplastics can reach the brain, although there is limited information regarding the number of particles that reaches the brain and the potential neurotoxicity of these small plastic particles. Earlier studies indicated that metal and metal-oxide nanoparticles, such as gold (Au) and titanium dioxide (TiO 2 ) nanoparticles, can also reach the brain to exert a range of neurotoxic effects. Given the similarities between these chemically inert metal(oxide) nanoparticles and plastic particles, this review aims to provide an overview of the reported neurotoxic effects of micro- and nanoplastics in different species and in vitro. The combined data, although fragmentary, indicate that exposure to micro- and nanoplastics can induce oxidative stress, potentially resulting in cellular damage and an increased vulnerability to develop neuronal disorders. Additionally, exposure to micro- and nanoplastics can result in inhibition of acetylcholinesterase activity and altered neurotransmitter levels, which both may contribute to the reported behavioral changes. Currently, a systematic comparison of the neurotoxic effects of different particle types, shapes, sizes at different exposure concentrations and durations is lacking, but urgently needed to further elucidate the neurotoxic hazard and risk of exposure to micro- and nanoplastics.

Background The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard ranking from high-throughput systems, and now allows for translation of exposures across in vitro and in vivo test systems. Complimentary particokinetic models that address processes controlling delivery of both particles and released ions to cells, and the influence of particle size changes from dissolution on particle delivery for cell-culture systems would help advance our understanding of the role of particles and ion dosimetry on cellular toxicology. We developed ISD3, an extension of our previously published model for insoluble particles, by deriving a specific formulation of the Population Balance Equation for soluble particles. Results ISD3 describes the time, concentration and particle size dependent dissolution of particles, their delivery to cells, and the delivery and uptake of ions to cells in in vitro liquid test systems. We applied the model to calculate the particle and ion dosimetry of nanosilver and silver ions in vitro after calibration of two empirical models, one for particle dissolution and one for ion uptake. Total media ion concentration, particle concentration and total cell-associated silver time-courses were well described by the model, across 2 concentrations of 20 and 110 nm particles. ISD3 was calibrated to dissolution data for 20 nm particles as a function of serum protein concentration, but successfully described the media and cell dosimetry time-course for both particles at all concentrations and time points. We also report the finding that protein content in media affects the initial rate of dissolution and the resulting near-steady state ion concentration in solution for the systems we have studied. Conclusions By combining experiments and modeling, we were able to quantify the influence of proteins on silver particle solubility, determine the relative amounts of silver ions and particles in exposed cells, and demonstrate the influence of particle size changes resulting from dissolution on particle delivery to cells in culture. ISD3 is modular and can be adapted to new applications by replacing descriptions of dissolution, sedimentation and boundary conditions with those appropriate for particles other than silver.

The current research deals with the use of single-cell inductively coupled plasma-mass spectrometry (scICP-MS) for the assessment of titanium dioxide nanoparticle (TiO2 NP) and silver nanoparticle (Ag NP) associations in cell lines derived from aquaculture species (sea bass, sea bream, and clams). The optimization studies have considered the avoidance of high dissolved background, multi-cell peak coincidence, and possible spectral interferences. Optimum operating conditions were found when using a dwell time of 50 μs for silver and 100 μs for titanium. The assessment of associated TiO2 NPs by scICP-MS required the use of ammonia as a reaction gas (flow rate at 0.75 mL min−1) for interference-free titanium determinations (measurements at an m/z ratio of 131 from the 48Ti(NH)(NH3)4 adduct). The influence of other parameters such as the number of washing cycles and the cell concentration on accurate determinations by scICP-MS was also fully investigated. Cell exposure trials were performed using PVP-Ag NPs (15 and 100 nm, nominal diameter) and citrate-TiO2 NPs (5, 25, and 45 nm, nominal diameter) at nominal concentrations of 10 and 50 μg mL−1 for citrate-TiO2 NPs and 5.0 and 50 μg mL−1 for PVP-Ag NPs. Results have shown that citrate-TiO2 NPs interact with the outer cell membranes, being quite low in the number of citrate-TiO2 NPs that enters the cells (the high degree of aggregation is the main factor which leads to the aggregates being in the extracellular medium). In contrast, PVP-Ag NPs have been found to enter the cells.