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The tobacco-free generation proposal advocates legislation precluding the sale and supply of tobacco to individuals born after a certain year. The measure is aimed at overcoming defects with current youth access laws that suffer from rite-of-passage and mixed signalling effects. Since its introduction in 2010, the proposal has attracted international attention, highlighting a number of matters that the present short article discusses. Efficacy issues, including retailer compliance, supply by surrogates and illicit sales, are addressed in the broader setting of community adherence to legislation. Encouragement for the likelihood of successful implementation is provided by historical precedents. In principle objections, relating to choice and generational fairness, are considered against the criteria of consistency and proportionality. It is concluded that the measure's emphasis on the welfare of future generations and its regard for the interests of existing stakeholders provide a feasible opportunity for the ultimate eradication of tobacco supply in appropriate jurisdictions.

Background Both obesity hypoventilation syndrome (OHS) and opium dependence can negatively affect nocturnal respiratory functionality. However, the effects of a combination of the two are relatively unknown. In this study, the tidal volume (VT) of OHS patients with and without opium dependence was estimated by measuring changes in the circumference of the thorax and the abdomen during sleep. Materials and methods This case–control study was performed in Iran, Isfahan. Initially, 20 healthy subjects calibrated the Pneumobelts (Löwenstein Medical Technology GmbH, Hamburg, Germany) by wearing the device and also breathing in and out of a Spirobag. From this, it was possible to estimate the coefficient factors for determining VT based on thoracic and abdominal measures. Subsequently, the study included 55 patients with OHS, who were divided into two groups: opium dependent and non-users. They were then admitted to the sleep lab for a single night of polysomnography (PSG). VT was estimated and then compared between groups. Results In total, there were 24 patients in the opium group and 31 in the non-user control group. All PSG variables were analyzed with independent-sample t -tests and an analysis of covariance was used to adjust for potential confounding variables. The following confounding variables were adjusted: sex, smoking, body mass index, and hypertension. VT values were not significantly different between groups (opium: 772 ± 125.4; non-user: 774 ± 95). Average oxygen saturation values were significantly lower in opium-dependent patients (opium: 86.1 ± 5.5; non-user: 89.1 ± 4.1). All other variables from PSG including chest and abdominal circumference were not significantly different between groups. Conclusion OHS patients with opium dependency showed similar VT levels when compared to non-users with OHS. Due to the rarity of the sample, it was difficult to gather exactly matched pairs. Therefore, it is possible that with a more closely related sample, we might be able to see a difference in VT between groups.

To explain the rise in Afghan opium production, we explore how rising conflicts change the incentives of farmers. Conflicts make illegal opportunities more profitable as they increase the perceived lawlessness and destroy infrastructure crucial to alternative crops. Exploiting a unique data set, we show that Western hostile casualties, our proxy for conflict, have a strong impact on subsequent local opium production. Using the period after the planting season as a placebo test, we show that conflict has a strong effect before but no effect after planting, indicating causality.

An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain. The revised recommendations presented here give guidance on the use of morphine and the alternative strong opioid analgesics which have been introduced in many parts of the world in recent years. Practical strategies for dealing with difficult situations are described presenting a consensus view where supporting evidence is lacking. The strength of the evidence on which each recommendation is based is indicated.

[...]as Mises states, \"interventionism is not an economic system ... it is not a method which enables people to achieve their aims\" ([1940] 1998, 78). Because information is dispersed across the economy often in the form of tacit knowledge (Hayek 1945), policy makers cannot fully anticipate, unless they are omniscient, how the changed information and incentives of market participants will ripple through the market and create secondary consequences that policy makers consider undesirable. [...]nothing was done to correct for the information problem created by forced labeling under the Pure Food and Drug Act. Because these newly labeled drugs were deemed dangerous and were now relatively more expensive, if not banned entirely, as heroin was by 1924, experimentation with other, previously less-utilized or unknown substances became popular, in particular marijuana, which in turn led to the passage of the Marihuana Tax Act of 1937.

Elicitor-induced sanguinarine accumulation in opium poppy (Papaver somniferum) cell cultures provides a responsive model system to profile modulations in gene transcripts and metabolites related to alkaloid biosynthesis. An annotated expressed sequence tag (EST) database was assembled from 10,224 random clones isolated from an elicitor-treated opium poppy cell culture cDNA library. The most abundant ESTs encoded defense proteins, and enzymes involved in alkaloid metabolism and S-adenosylmethionine-dependent methyl transfer. ESTs corresponding to 40 enzymes involved in the conversion of sucrose to sanguinarine were identified. A corresponding DNA microarray was probed with RNA from cell cultures collected at various time-points after elicitor treatment, and compared with RNA from control cells. Several diverse transcript populations were coordinately induced, with alkaloid biosynthetic enzyme and defense protein transcripts displaying the most rapid and substantial increases. In addition to all known sanguinarine biosynthetic gene transcripts, mRNAs encoding several upstream primary metabolic enzymes were coordinately induced. Fourier transform-ion cyclotron resonance-mass spectrometry was used to characterize the metabolite profiles of control and elicitor-treated cell cultures. Principle component analysis revealed a significant and dynamic separation in the metabolome, represented by 992 independent detected analytes, in response to elicitor treatment. Identified metabolites included sanguinarine, dihydrosanguinarine, and the methoxylated derivatives dihydrochelirubine and chelirubine, and the alkaloid pathway intermediates N-methylcoclaurine, N-methylstylopine, and protopine. Some of the detected analytes showed temporal changes in abundance consistent with modulations in the profiles of alkaloid biosynthetic gene transcripts.

Soviet officials routinely remarked that the Bolshevik Revolution had destroyed the socioeconomic base from which drug use and addiction sprung. Yet, authorities also anxiously reported rising instances of drug use among Soviet youth during the 1950s and 1960s. Through the use of recently declassified Komsomol and police documents from Russian archives, this article examines both the consumptive practices of youth and the measures taken by Soviet authorities to combat this development. Within the liberalizing climate of the Khrushchev-era \"Thaw,\" youth authorities crafted educational and cultural strategies to draw youth away from narcotics. Beginning in the mid-1960s, their emphasis shifted to favor openly punitive strategies as a means of curbing the illegal drug supply and discouraging usage. Contrary to official rhetoric, the consumption of narcotics did not necessarily constitute a political statement or indicate opposition to Soviet power. Instead, drugs could provide an alluring alternative to state-sanctioned leisure practices.

For decades, cocaine was the narcotic of choice in the United States. For decades it drove the so-called war on drugs against Colombian and Mexican drug cartels, depicted in films like Clear and Present Danger and more recently in the popular Netflix series Narcos. Narcotics consumption in the United States, however, has recently shifted from cocaine to opioids like heroin and, increasingly, from plant-based to synthetic drugs like methamphetamines and fentanyl. Heroin use has spread into suburban and rural communities and is growing among most socioeconomic classes, age groups, and races. Potent synthetic opioids like fentanyl have become mixed into black-market supplies of heroin, cocaine, and methamphetamine and are fueling a high-mortality rate, and compounding the crisis. Sadly, the current opioid crisis is reminiscent of past periods of addiction and overdose deaths in the United States.

The effects of socioecological transformations such as climate change, the collapse of the Soviet empire, and civil war are examined for 14 villages in the valleys of the Pamir Mountains in the historical Badakhshan region, now divided between Afghanistan and Tajikistan. Preliminary findings indicate concern for food sovereignty, evidence of biocultural impacts of climate change, an increasing burden on women, debilitating opium addiction, the ecological importance of sacred sites, and other priorities related to sustainable livelihoods, such as energy needs (for fuel and lighting) and physical and social infrastructure in the form of roads and schools. In the complex setting of the Pamir Mountains, characterized by both cultural and ecological diversity and marked by artificial political boundaries, the creative and pragmatic interaction between indigenous and scientific knowledge sustains the best hope for survival. Applied research must combine communities of inquirers (research institutions) with communities of social practitioners (farmers, pastoralists, and civil society institutions) to facilitate indigenous participation in generating context-specific knowledge. The goal of such research is practical outcomes that will meet the urgent priorities of village communities. This paper establishes a baseline from which undertake applied human ecological research related to livelihood security.