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50 natural wonders to blow your mind
In today's age of information, there are smartphones in the most remote corners of our world and our cities are huge bustling metropolises growing larger by the day. But despite this cumulative urbanisation, there is a tacit understanding among the human race that connection to nature is an essential factor in our happiness. For all our obsession with man-made wonders nothing compares to the creations of Mother Nature. Vast underground cave systems, wild desert landscapes, breathtaking waterfalls, staggering geology and spectacular vestiges of our prehistoric past all remind us of our small place in earth's story. And even with our ever-expanding knowledge of the way the world came to be, some landscapes still leave us utterly perplexed. This is the mystery and the majesty of the natural world. In this book we've attempted to capture just a fraction of what it has to offer, and we hope it inspires you to get out and find your own slice of pleasure in the great outdoors.
Book
Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile
ObjectiveAs the development and progression of colorectal cancer (CRC) are known to be affected by the immune system, cell subsets such as T cells, natural killer (NK) cells, and natural killer T (NKT) cells are considered interesting targets for immunotherapy and clinical biomarker research. Until now, the role of systemic immune profiles in tumor progression remains unclear. In this study, we aimed to characterize the immunophenotype of circulating T cells, NK cells, and NKT-like cells in patients with CRC, and to subsequently correlate these immunophenotypes to clinical follow-up data.MethodsUsing multiparameter flow cytometry, the subset distribution and immunophenotype of T cells (CD3+CD56−), CD56dim NK cells (CD3−CD56dim), CD56bright NK cells (CD3−CD56bright), and NKT-like (CD3+CD56+) cells were investigated in peripheral blood mononuclear cell (PBMC) samples from 71 CRC patients and 19 healthy donors.ResultsCRC patients showed profound differences in immune cell subset distribution and their immunophenotype compared to healthy donors, as characterized by increased percentage of regulatory T cells, and reduced expression level of the natural cytotoxicity receptors NKp44 and NKp46 on both CD56dim NK cells and NKT-like cells. Finally, we showed in a multivariate analysis that above-median percentage of CD16+ NKT-like cells was independently associated with shorter disease-free survival in CRC patients.ConclusionThe altered phenotype of circulating immune cell subsets in CRC and its association with clinical outcome highlight the potential use of PBMC subsets as prognostic biomarkers in CRC, thereby contributing to better insight into the role of systemic immune profiles in tumor progression.
Journal Article
The race for what's left : the global scramble for the world's last resources
Journalist Klare describes the impact the coming shortage of natural resources will have on the future of the human race.
Book
Super clean super foods
Featuring 350 easy ways to enjoy 90 nutrient-filled whole foods, Super Clean Super Foods shows you how to incorporate each one into your everyday diet, along with illustrations that teach you how to prepare unfamiliar ingredients. From quinoa and chia seeds to spinach and pomegranate, this guide uses unprocessed and minimally processed foods that avoid added sugar, salt, and unwanted fats. Explore the health properties of phytonutrients, dietary fiber, whole grains, and seasonally and locally grown fruits and vegetables that will better your body and the environment, and work toward specific goals with food plans for better sleep, gut health, brain health, and more.
Book
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo
NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be determined what specific molecular interactions are involved and whether NK cells control metastatic progression and/or the route of dissemination. Here we show that human melanoma cell lines derived from LN metastases express ligands for natural cytotoxicity receptors (NCRs) and DNAX accessory molecule-1 (DNAM-1), two emerging NK cell receptors key for cancer cell recognition, but not NK group 2 member D (NKG2D). Compared with cell lines derived from metastases taken from other anatomical sites, LN metastases were more susceptible to NK cell lysis and preferentially targeted by adoptively transferred NK cells in a xenogeneic model of cell therapy. In mice, DNAM-1 and NCR ligands were also found on spontaneous melanomas and melanoma cell lines. Interference with DNAM-1 and NCRs by antibody blockade or genetic disruption reduced killing of melanoma cells. Taken together, these results show that DNAM-1 and NCRs are critical for NK cell-mediated innate immunity to melanoma cells and provide a background to design NK cell-based immunotherapeutic strategies against melanoma and possibly other tumors.
Journal Article
Sociable Knowledge
Working with the technologies of pen and paper, scissors and glue, naturalists in early modern England, Scotland, and Wales wrote, revised, and recombined their words, sometimes over a period of many years, before fixing them in printed form. They built up their stocks of papers by sharing these materials through postal and less formal carrier services. They exchanged letters, loose notes, drawings and plans, commonplace books, as well as lengthy treatises, ever-expanding repositories for new knowledge about nature and history as it accumulated through reading, observation, correspondence, and conversation. These textual collections grew alongside cabinets of natural specimens, antiquarian objects, and other curiosities-insects pinned in boxes, leaves and flowers pressed in books, rocks and fossils, ancient coins and amulets, and drafts of stone monuments and inscriptions. The goal of all this collecting and sharing, Elizabeth Yale claims, was to create channels through which naturalists and antiquaries could pool their fragmented knowledge of the hyperlocal and curious into an understanding and representation of Britain as a unified historical and geographical space.
Sociable Knowledgepays careful attention to the concrete and the particular: the manuscript almost lost off the back of the mail carrier's cart, the proper ways to package live plants for transport, the kin relationships through which research questionnaires were distributed. The book shows how naturalists used print instruments to garner financing and content from correspondents and how they relied upon research travel-going out into the field-to make and refresh social connections. By moving beyond an easy distinction between print and scribal cultures, Yale reconstructs not just the collaborations of seventeenth-century practitioners who were dispersed across city and country, but also the ways in which the totality of their exchange practices structured early modern scientific knowledge.
eBook
Earth's resources geo facts
\"Learn about the kind of resources Earth holds, and how they are extracted and used. Discover the problems and challenges posed by human consumption of these resources, from overfishing to dwindling supplies of fossil fuels\"--Amazon.com.
Book
