Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
7
result(s) for
"Neuronal Plasticity Congresses."
Sort by:
Plasticity and Pathology
With the rise of cognitive science and the revolution in neuroscience, it is now commonplace to assume that the study of a human person-a thinking, feeling, acting subject-is ultimately the study of the human brain. In both Europe and the United States, massive state-funded research is focused on mapping the brain in all its remarkable complexity. The metaphors employed are largely technological: A wiring diagram of synaptic connectivity will lead to a better understanding of human behavior and perhaps insights into the breakdown of human personhood with diseases of the brain such as Alzheimer's. Alongside this technologized discourse of the brain as locus of human subjectivity we find another perspective, one that emphasizes its essential plasticity-in both the developmental sense and as a response to traumas such as strokes, tumors, or gunshot wounds. This collection of essays brings together a diverse range of scholars to investigate how the \"neural subject\" of the twenty-first century came to be. Taking approaches both historical and theoretical, they probe the possibilities and limits of neuroscientific understandings of human experience. Topics include landmark studies in the history of neuroscience, the relationship between neural and technological \"pathologies,\" and analyses of contemporary concepts of plasticity and pathology in cognitive neuroscience. Central to the volume is a critical examination of the relationship between pathology and plasticity. Because pathology is often the occasion for neural reorganization and adaptation, it exists not in opposition to the brain's \"normal\" operation but instead as something intimately connected to our ways of being and understanding.
eBook
Plasticity and Pathology: On the Formation of the Neural Subject
This collection of essays explores the historical and theoretical dimensions of the contemporary neural subject. With a multidisciplinary perspective, the volume focuses attention on the important, but problematic notion of plasticity as a way of rethinking the relationship between human experience and both pathological and normal states of the nervous system.
eBook
Spontaneous Synaptic Activity in Projection Neurons of Lamina I of the Isolated Rat Lumbar Spinal Cord: Effect of Peripheral Inflammation
Spino-cerebral (projection) neurons localized in lamina I of the spinal gray substance play an important role in the transmission of pain-related information to the brain. We examined spontaneous excitatory postsynaptic currents (sEPSC) recorded from lamina I spino-pontine neurons in isolated preparations of the rat lumbar spinal cord; the respective neurons were retrogradely labeled by a fluorescent dye. We tried to find out how experimentally induced peripheral inflammation affects the amplitude/time characteristics of these currents. It was found that, in preparations obtained from animals with inflammation of hind limb tissues, the frequency and (to a lesser extent) amplitude of sEPSC in projection neurons are, on average, higher than those measured in neurons of the control animals. It is belived that such changes result mostly from plastic modifications of neuron-to-neuron interactions in neuronal networks of lamina II, which form main synaptic inputs to neurons of lamina I. Increased frequency and amplitude of sEPSC in lamina I neurons should lead to some facilitation of transmission of nociceptive information to the cerebral structures. Such hyperexcitability of lamina 1 projection neurons can provide a notable contribution to the development of hyperalgesia in chronic inflammatory states and to facilitation of generation of pain-related emotions.
Journal Article
Perspective
In July 2005, physical therapy clinicians, educators, and researchers gathered for the IIISTEP (Symposium on Translating Evidence to Practice) conference. The purpose of IIISTEP was to link research and clinical practice through the exchange of ideas and research findings between scientists and clinicians. This paper represents the personal perspective of a group of colleagues who attended IIISTEP as clinicians/educator teams. The purpose of this paper is to illustrate how information from IIISTEP has challenged our existing concepts regarding physical therapy practice and begun to alter our clinical practice. Some key concepts presented by scientists and clinicians at IIISTEP are reviewed including current perspectives on neuroplasticity and frameworks for considering function, health, and the disablement process. Considerations for clinical application are outlined. Patient cases are used to illustrate how integration of this information has altered our approach to patient management.
Journal Article