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Background Precise insertion of pedicle screws is important to avoid injury to closely adjacent neurovascular structures. The standard method for the insertion of pedicle screws is based on anatomical landmarks (free-hand technique). Head-mounted augmented reality (AR) devices can be used to guide instrumentation and implant placement in spinal surgery. This study evaluates the feasibility and precision of AR technology to improve precision of pedicle screw insertion compared to the current standard technique. Methods Two board-certified orthopedic surgeons specialized in spine surgery and two novice surgeons were each instructed to drill pilot holes for 40 pedicle screws in eighty lumbar vertebra sawbones models in an agar-based gel. One hundred and sixty pedicles were randomized into two groups: the standard free-hand technique (FH) and augmented reality technique (AR). A 3D model of the vertebral body was superimposed over the AR headset. Half of the pedicles were drilled using the FH method, and the other half using the AR method. Results The average minimal distance of the drill axis to the pedicle wall (MAPW) was similar in both groups for expert surgeons (FH 4.8 ± 1.0 mm vs. AR 5.0 ± 1.4 mm, p = 0.389) but for novice surgeons (FH 3.4 mm ± 1.8 mm, AR 4.2 ± 1.8 mm, p = 0.044). Expert surgeons showed 0 primary drill pedicle perforations (PDPP) in both the FH and AR groups. Novices showed 3 (7.5%) PDPP in the FH group and one perforation (2.5%) in the AR group, respectively ( p > 0.005). Experts showed no statistically significant difference in average secondary screw pedicle perforations (SSPP) between the AR and the FH set 6-, 7-, and 8-mm screws ( p > 0.05). Novices showed significant differences of SSPP between most groups: 6-mm screws, 18 (45%) vs. 7 (17.5%), p = 0.006; 7-mm screws, 20 (50%) vs. 10 (25%), p = 0.013; and 8-mm screws, 22 (55%) vs. 15 (37.5%), p = 0.053, in the FH and AR group, respectively. In novices, the average optimal medio-lateral convergent angle (oMLCA) was 3.23° (STD 4.90) and 0.62° (STD 4.56) for the FH and AR set screws ( p = 0.017), respectively. Novices drilled with a higher precision with respect to the cranio-caudal inclination angle (CCIA) category ( p = 0.04) with AR. Conclusion In this study, the additional anatomical information provided by the AR headset superimposed to real-world anatomy improved the precision of drilling pilot holes for pedicle screws in a laboratory setting and decreases the effect of surgeon’s experience. Further technical development and validations studies are currently being performed to investigate potential clinical benefits of the herein described AR-based navigation approach.

Background Despite the widespread use of external ventricular drainage, revision rates, and associated complications are reported between 10 and 40%. Current available image-guided techniques using stereotaxy, endoscopy, or ultrasound for catheter placements remain time-consuming techniques. Recently, a smartphone-assisted guide with high precision has been described. The development of an easy-to-use, portable, image-guided system could reduce the need for multiple passes and improve the rate of accurate catheter placement. This study aims to prospectively compare in a randomized controlled manner the accuracy of the freehand pass technique versus an easy-to-use, portable, adjustable guiding device for ventriculostomy catheter placement. Methods/Design This is a single center, prospective, randomized trial with a blinded endpoint (ventricular catheter tip location) assessment. Adult patients with the indication for ventriculostomy, as proven by computed tomography (CT), will be randomly assigned to the treatment group or the control group. For patients in the treatment group, ventriculostomy will be performed using an adjustable guiding device and DICOM (Digital Imaging and Communications in Medicine) image-reading software assistance (for example, using a mini-tablet) based on preoperative CT imaging. Patients in the control group will receive standard freehand ventriculostomy using anatomical landmarks. The catheter may be placed for external drainage or internal (ventriculoperitoneal) shunting in both groups. The primary outcome measure is the rate of correct placements of the ventricular catheter, defined as a score of 1 to 3 on grading system for catheter tip location on a postoperative CT scan. Participants will be followed for the duration of hospital stay, an expected average of two weeks. The primary outcome will be determined by one of the authors blinded to the treatment allocation. We aim to include 236 patients in three years. Secondary outcome measures include: frequency of placements required, frequency of completed placements within the ventricle of the perforated part of the catheter tip, frequency of very early and early shunt failures (revision of the ventricular drainage within 24 hours and within the hospital stay), frequency and percentage of complications (procedure-related and nonsurgical) at discharge. Discussion This is the study design of a single center, prospective, randomized controlled trial to investigate whether guided ventriculostomy is superior to the standard freehand technique. One strength of this study is the prospective, randomized, interventional type of study testing a new easy-to-handle guided versus freehand ventricular catheter placement. A second strength of this study is that the power calculation is based on catheter accuracy using an available grading system for catheter tip location, and is calculated with the use of recent study results of our own population, supported by data from prominent studies. Trial registration Clinicaltrials.gov identifier: NCT02048553 (registered on 28 January 2014).

For frameless stereotaxy, users can choose between anatomic landmarks (ALs) or surface fiducial markers (FMs) for their match points during registration to define an alignment of the head in the physical and radiographic image space. In this study, we sought to determine the concordance among a point-merged FM registration, a point-merged AL registration, and a combined point-merged anatomic/surface-merged (SM) registration, i.e., to determine the accuracy of registration techniques with and without FMs by examining the extent of agreement between the system-generated predicted value and physical measured values. We examined 30 volunteers treated with gamma knife surgery. The frameless stereotactic image-guidance system called the StealthStation (Medtronic Surgical Navigation Technologies, Louisville, CO) was used. Nine FMs were placed on the patient's head and four were placed on a Leksell frame rod-box, which acted as a rigid set to determine the difference in error. For each registration form, we recorded the generated measurement (GM) and the physical measurement (PM) to each of the four checkpoint FMs. Bland and Altman plot difference analyses were used to compare measurement techniques. Correlations and descriptive analyses were completed. The mean of values for GMs were 1.14 mm for FM, 2.3 mm for AL, and 0.96 mm for SM registrations. The mean errors of the checkpoints were 3.49 mm for FM, 3.96 mm for AL, and 3.33 mm for SM registrations. The correlation between GMs and PMs indicated a linear relationship for all three methods. AL registration demonstrated the greatest mean difference, followed by FM registration; SM registration had the smallest difference between GMs and PMs. Differences in the anatomic registration methods, including SM registration, compared with FM registration were within a mean +/- 1.96 (standard deviation) according to the Bland and Altman analysis. For our sample of 30 patients, all three registration methods provided comparable distances to the target tissue for surgical procedures. Users may safely choose anatomic registration as a less costly and more time-efficient registration method for frameless stereotaxy.

Point-pair registration is widely used in an image-guided neurosurgery system. Poor distribution of the fiducial points leads to an increase in the target registration error (TRE). This study aimed to provide templates consisting of optimized positioning of the fiducial points to reduce the TRE in image-guided neurosurgery. We divided the head into 6 regions and provided distribution templates of the fiducial points for each of them. A variable termed TREM(r) was used to express the approximate expected square of the TRE at the target point with a specified distribution of fiducial points. We randomly selected 85 patients from 5 hospitals who underwent image-guided neurosurgery and compared the TREM(r) of the real fiducial points with that of the templates. We grouped the patients by hospitals and regions. The mean TREM(r)s of the templates were much smaller than those of the real fiducial points. In each group, the range of the TREM(r) values of the templates was much smaller than that of the real fiducial points. This study provides an easy method to implement a good distribution of the fiducial points to help reduce TRE in image-guided neurosurgery. The templates are simple and exact and can be easily integrated into current workflow.

Even though robotic technology holds great potential for performing spinal surgery and advancing neurosurgical techniques, it is of utmost importance to establish its practicality and to demonstrate better clinical outcomes compared with traditional techniques, especially in the current cost-effective era. Several systems have proved to be safe and reliable in the execution of tasks on a routine basis, are commercially available, and are used for specific indications in spine surgery. However, workflow, usability, interdisciplinary setups, efficacy, and cost-effectiveness have to be proven prospectively. This article includes a short description of robotic structures and workflow, followed by preliminary results of a randomized prospective study comparing conventional free-hand techniques with routine spine navigation and robotic-assisted procedures. Additionally, we present cases performed with a spinal robotic device, assessing not only the accuracy of the robotic-assisted procedure but also other factors (eg, minimal invasiveness, radiation dosage, and learning curves). Currently, the use of robotics in spinal surgery greatly enhances the application of minimally invasive procedures by increasing accuracy and reducing radiation exposure for patients and surgeons compared with standard procedures. Second-generation hardware and software upgrades of existing devices will enhance workflow and intraoperative setup. As more studies are published in this field, robot-assisted therapies will gain wider acceptance in the near future.

Purpose Neurosurgical biopsies require high accuracy and precision and are executed with image-guided surgical navigation. The current state-of-the-art techniques require markers, are displayed on a 2D screen, and have a time-consuming setup. We propose an AR-driven surgical navigation method that automatically projects a 3D virtual overlay onto a patient in real-time, without the use of any markers. Method Baseline accuracy of the proposed system and the StealthStation S8 was measured on a 3D printed human head phantom in a lab-based setting. For the measurements in the operating room, seventeen participants who underwent a neurosurgical biopsy with the StealthStation S8 were included. Prior to the clinical procedure, our proposed markerless AR system provided an automated three-dimensional virtual overlay onto the patient to the surgeon. By measuring the difference in the planned biopsy trajectory between the state-of-the-art StealthStation S8 and our experimental system, a comparison was made between the two systems. Results The average clinical error for the entry point of the proposed system was 4.5 ± 2.2 mm, which is lower than the total error of the current clinical gold standard found in literature. Conclusion The total error of the system proposed in this study reaches the gold standard for image-guided neuronavigation, in both lab-controlled and clinical settings. These initial results highlight the potential and advantages of AR over other methods, offering promising AR opportunities for future clinical applications.

Neuronavigation has become an intrinsic part of preoperative surgical planning and surgical procedures. However, many surgeons have the impression that accuracy decreases during surgery. To quantify the decrease of neuronavigation accuracy and identify possible origins, we performed a retrospective quality-control study. Between April and July 2011, a neuronavigation system was used in conjunction with a specially prepared head holder in 55 consecutive patients. Two different neuronavigation systems were investigated separately. Coregistration was performed with laser-surface matching, paired-point matching using skin fiducials, anatomic landmarks, or bone screws. The initial target registration error (TRE1) was measured using the nasion as the anatomic landmark. Then, after draping and during surgery, the accuracy was checked at predefined procedural landmark steps (Mayfield measurement point and bone measurement point), and deviations were recorded. After initial coregistration, the mean (SD) TRE1 was 2.9 (3.3) mm. The TRE1 was significantly dependent on patient positioning, lesion localization, type of neuroimaging, and coregistration method. The following procedures decreased neuronavigation accuracy: attachment of surgical drapes (DTRE2 = 2.7 [1.7] mm), skin retractor attachment (DTRE3 = 1.2 [1.0] mm), craniotomy (DTRE3 = 1.0 [1.4] mm), and Halo ring installation (DTRE3 = 0.5 [0.5] mm). Surgery duration was a significant factor also; the overall DTRE was 1.3 [1.5] mm after 30 minutes and increased to 4.4 [1.8] mm after 5.5 hours of surgery. After registration, there is an ongoing loss of neuronavigation accuracy. The major factors were draping, attachment of skin retractors, and duration of surgery. Surgeons should be aware of this silent loss of accuracy when using neuronavigation.

Navigated suction devices may enhance intraoperative efficiency and maximize safe resection of infiltrative gliomas by providing real-time anatomical guidance. However, their use and safety in high-grade glioma (HGG) surgery is unreported. We evaluated the safety and feasibility of a neuronavigation-integrated suction (NIS) device compared to conventional neuronavigation in patients undergoing resection for HGGs. We utilized an NIS device in 33 HGG (WHO grade III/IV) resections. We retrospectively collected data on 174 HGG resections using standard neuronavigation during the same period, then performed propensity score matching (age, sex, prior treatment, tumor grade, tumor location, IDH status) to create 33 matched pairs (NIS vs. control, n = 66). Outcomes included extent of resection, operative time, estimated blood loss (EBL), complications, and length of stay (LOS). Baseline characteristics, including age (P = 0.299), sex (P = 0.319), tumor laterality (P = 0.196), anatomic location (P = 0.861), eloquent area (P = 0.769), tumor grade (P = 1.000), IDH mutation status (P = 0.415), prior resection (P = 0.602), and prior radiation therapy (P = 0.071), were comparable between groups. The NIS group had shorter operative times (193.7 ± 52.0 vs. 230.5 ± 69.2 min, P = 0.009). Intended GTR was more common with NIS (95 % vs. 65.2 %, P = 0.017). LOS was shorter in the NIS group (median 2.0 [1.75, 2.25] vs. 2.0 [1.5, 13.0] days, P = 0.030) with fewer postoperative complications (6.1 % vs. 30.3 %, P = 0.011). EBL (P = 0.418) and intraoperative complications (P = 0.314) were similar. Recurrence (57.6 %) and six-month mortality (21.2 %) were similar; there was no significant difference in median overall survival (control: 362 [110.5, 498.8] vs. NIS: 428 [177.5, 536] days, P = 0.237). The NIS device was feasible to use in high-grade glioma surgery, and its use did not appear to compromise resection quality, complication rates, or oncologic outcomes. As neuronavigation and real-time intraoperative technologies advance, integrating such tools may further enhance surgical precision and patient outcomes for infiltrative gliomas. Future prospective, randomized studies should refine this technology and explore its broader impact on neurosurgical practice. •First formal retrospective study of NIS safety and institutional experience.•NIS did not prolong operations or worsen perioperative/oncologic outcomes.•Implementation was feasible, with a learning curve that was not insurmountable.

Spatial accuracy in electrophysiological investigations is paramount, as precise localization and reliable access to specific brain regions help the advancement of our understanding of the brain’s complex neural activity. Here, we introduce a novel, multi camera-based, frameless neuronavigation technique for precise, 3-dimensional electrode positioning in awake monkeys. The investigation of neural functions in awake primates often requires stable access to the brain with thin and delicate recording electrodes. This is usually realized by implanting a chronic recording chamber onto the skull of the animal that allows direct access to the dura. Most recording and positioning techniques utilize this implanted recording chamber as a holder of the microdrive or to hold a grid. This in turn reduces the degrees of freedom in positioning. To solve this problem, we require innovative, flexible, but precise tools for neuronal recordings. We instead mount the electrode microdrive above the animal on an arch, equipped with a series of translational and rotational micromanipulators, allowing movements in all axes. Here, the positioning is controlled by infrared cameras tracking the location of the microdrive and the monkey, allowing precise and flexible trajectories. To verify the accuracy of this technique, we created iron deposits in the tissue that could be detected by MRI. Our results demonstrate a remarkable precision with the confirmed physical location of these deposits averaging less than 0.5 mm from their planned position. Pilot electrophysiological recordings additionally demonstrate the accuracy and flexibility of this method. Our innovative approach could significantly enhance the accuracy and flexibility of neural recordings, potentially catalyzing further advancements in neuroscientific research.

Background Augmented reality technology has been used for intraoperative image guidance through the overlay of virtual images, from preoperative imaging studies, onto the real-world surgical field. Although setups based on augmented reality have been used for various neurosurgical pathologies, very few cases have been reported for the surgery of arteriovenous malformations (AVM). We present our experience with AVM surgery using a system designed for image injection of virtual images into the operating microscope’s eyepiece, and discuss why augmented reality may be less appealing in this form of surgery. Methods N  = 5 patients underwent AVM resection assisted by augmented reality. Virtual three-dimensional models of patients’ heads, skulls, AVM nidi, and feeder and drainage vessels were selectively segmented and injected into the microscope’s eyepiece for intraoperative image guidance, and their usefulness was assessed in each case. Results Although the setup helped in performing tailored craniotomies, in guiding dissection and in localizing drainage veins, it did not provide the surgeon with useful information concerning feeder arteries, due to the complexity of AVM angioarchitecture. Conclusion The difficulty in intraoperatively conveying useful information on feeder vessels may make augmented reality a less engaging tool in this form of surgery, and might explain its underrepresentation in the literature. Integrating an AVM’s hemodynamic characteristics into the augmented rendering could make it more suited to AVM surgery.