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My plastic brain : one woman's yearlong journey to discover if science can improve her mind
\"Using herself as a guinea pig, a science journalist explores 'neuroplasticity' to find out whether she can make meaningful, lasting changes to the way her brain works\"-- Provided by publisher.
Book
35904 Mitochondrial dysfunction as triggering in complex regional pain syndrome
Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page)Background and Aims
Complex regional pain syndrome (CRPS) is characterized by being disproportionate to the triggering event; the associated characteristics are autonomic dysfunction, swelling of the zone of affection, and even changes in the skin, such as dystrophy and rigidity. The pathophysiology is still unknown; it has been mentioned as a multifactorial disorder, with an exaggerated immune response to the triggering event, abnormal vasomotor function, and even maladaptive neuroplasticity. This study aimed to evaluate the differently expressed genes (DEG) between 4 patients with complex regional pain syndrome vs. healthy controls and analyze the pathways intervening.MethodsMaterial/Methods: The gene expression dataset GSE47603 was downloaded from the GEO database, and DEG obtained. The highest up-regulated genes were examined in the String platform for the protein-protein interaction (PPI) network.ResultsResults: 60 primary genes up-regulated were identified according to the Log2-fold change statistics. The network for the 60 genes was sub-selected in clusters in STRING, obtaining a network of 20 nodes, 24 edges, and a PPI enrichment p-value of 3.73e-11. The principal intervening pathways were mitochondrial ATP synthesis, the electron transport chain, and lysosome vesicle biogenesis.Abstract #35904 Figure 1Meandiff plot of genes expressed in CRPS Vs controls[Figure omitted. See PDF]Abstract #35904 Figure 2CRPS cluster of 20 nodes, with the principal proteins involved in mitochondrial functions[Figure omitted. See PDF]ConclusionsWe found a relevant participation of mitochondrial metabolism in the PPI network that has not been mentioned before as a pain onset in CRPS, but at the same time presence of pain has been reported in patients with mitochondrial disease, the essential role that it could play in the sudden development of pain in CRPS needs to be further analyzed.
Journal Article
The woman who changed her brain : unlocking the extraordinary potential of the human mind
This is the incredible story and miraculous work of a remarkable woman. Though she began life severely learning disabled, she built herself a better brain and a brain training program that has helped thousands of others do the same.
ABSTRACT NUMBER: ESOC2026A1467 BIOMARKERS OF NEUROPLASTICITY IN PREDICTING OUTCOMES OF HEMORRHAGIC STROKE
Abstract
Background and aims
Glial cell line-derived neurotrophic factor (GDNF), predominantly expressed in astrocytes, plays an important role in regulating microglial activation, limiting neuroinflammation, and protecting against neurodegeneration in hemorrhagic stroke. To investigate the role of GDNF in the acute phase of hemorrhagic stroke as a predictor of disease outcome.
Methods
Eighty-three patients with hemorrhagic stroke of various localizations in the acute phase were examined, including 45 men (54.2%) and 38 women (45.7%), with a mean age of 62.3 years. Neurological status and stroke severity were assessed using the NIHSS, FOUR score, Barthel Index, and modified Rankin Scale. Patients were classified according to stroke severity. Serum GDNF levels were measured and compared with a control group.
Results
The mean GDNF level in the control group was 28.1 pg/mL. In patients with hemorrhagic stroke, GDNF levels increased significantly to 46.7 pg/mL within the first 3 hours after onset (p<0.05). By day 14, GDNF levels decreased to 35.3 pg/mL (p<0.05 compared with control), and by day 30 to 32.1 pg/mL (p<0.05 compared with the 3-hour value). Patients with an unfavorable clinical course showed stable or decreasing GDNF levels during the acute phase. In contrast, patients with a favorable course demonstrated a significant increase in GDNF levels on day 14.
Conclusions
Neuroplasticity processes remain active even in severe hemorrhagic stroke. Dynamic changes in GDNF levels reflect neuroinflammatory and neuroplastic responses and may serve as predictors of disease outcome and potential therapeutic targets.
Conflict of interest
Fayzullo Mallayev: nothing to disclose
Journal Article
The brain's way of healing : remarkable discoveries and recoveries from the frontiers of neuroplasticity
\" The New York Times bestselling author of The Brain That Changes Itself presents astounding advances in the treatment of brain injury and illness. In The Brain That Changes Itself, Norman Doidge described the most important breakthrough in our understanding of the brain in four hundred years: the discovery that the brain can change its own structure and function in response to mental experience-what we call neuroplasticity. His revolutionary new book shows, for the first time, how the amazing process of neuroplastic healing really works. It describes natural, non-invasive avenues into the brain provided by the forms of energy around us-light, sound, vibration, movement-which pass through our senses and our bodies to awaken the brain's own healing capacities without producing unpleasant side effects. Doidge explores cases where patients alleviated years of chronic pain or recovered from debilitating strokes or accidents; children on the autistic spectrum or with learning disorders normalizing; symptoms of multiple sclerosis, Parkinson's disease, and cerebral palsy radically improved, and other near-miracle recoveries. And we learn how to vastly reduce the risk of dementia with simple approaches anyone can use. For centuries it was believed that the brain's complexity prevented recovery from damage or disease. The Brain's Way of Healing shows that this very sophistication is the source of a unique kind of healing. As he did so lucidly in The Brain That Changes Itself, Doidge uses stories to present cutting-edge science with practical real-world applications, and principles that everyone can apply to improve their brain's performance and health\"-- Provided by publisher.
Book
ABSTRACT NUMBER: ESOC2026A1457 THE RELATIONSHIP BETWEEN LEVELS OF NEUROINFLAMMATORY BIOMARKERS AND NEUROPLASTICITY IN THE ACUTE PERIOD OF HEMORRHAGIC STROKES
Abstract
Background and aims
To evaluate the levels and relationship between the inflammatory marker vascular cell adhesion molecule-1 (VCAM-1) and the neuroplasticity marker glial cell line-derived neurotrophic factor (GDNF) in patients with acute hemorrhagic stroke.
Methods
Sixty-five patients with hemorrhagic stroke (30 women, 35 men; mean age 62.3 years) were examined. Hemorrhage types included subarachnoid (8.4%), parenchymal (53%), ventricular (9.6%), subarachnoid-ventricular (8.4%), and parenchymal-ventricular (6%). Stroke severity and functional status were assessed using the Glasgow Coma Scale, Barthel Index, and modified Rankin Scale. Serum VCAM-1 and GDNF levels were measured by enzyme-linked immunosorbent assay. Hemorrhage volume was determined using brain computed tomography.
Results
Elevated VCAM-1 expression was observed within the first 24 hours after stroke onset and showed a positive correlation with hemorrhage volume, with higher levels detected in patients with large intracerebral hemorrhages. GDNF levels demonstrated an inverse correlation with hemorrhage volume on day 12. Patients with an unfavorable clinical course had high VCAM-1 levels combined with reduced GDNF concentrations. In contrast, patients with a favorable course exhibited lower VCAM-1 levels and a significant increase in GDNF by day 12. During the early recovery period, VCAM-1 levels correlated with the Barthel Index, while GDNF levels correlated with the modified Rankin Scale.
Conclusions
Measurement of serum VCAM-1 and GDNF levels may be useful for assessing disease severity, predicting outcomes, and supporting personalized therapeutic strategies in patients with hemorrhagic stroke.
Conflict of interest
Fayzullo Mallayev: nothing to disclose
Journal Article